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Microbiol Mol Biol Rev, March 1998, p. 230-247, Vol. 62, No. 1
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Vacuole Biogenesis in Saccharomyces cerevisiae: Protein Transport Pathways to the Yeast Vacuole

Nia J. Bryant and Tom H. Stevens*

Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 

Delivery of proteins to the vacuole of the yeast Saccharomyces cerevisiae provides an excellent model system in which to study vacuole and lysosome biogenesis and membrane traffic. This organelle receives proteins from a number of different routes, including proteins sorted away from the secretory pathway at the Golgi apparatus and endocytic traffic arising from the plasma membrane. Genetic analysis has revealed at least 60 genes involved in vacuolar protein sorting, numerous components of a novel cytoplasm-to-vacuole transport pathway, and a large number of proteins required for autophagy. Cell biological and biochemical studies have provided important molecular insights into the various protein delivery pathways to the yeast vacuole. This review describes the various pathways to the vacuole and illustrates how they are related to one another in the vacuolar network of S. cerevisiae.

* Corresponding author. Mailing address: Institute of Molecular Biology, University of Oregon, Eugene, OR 97403-1229. Phone: (541) 346-5884. Fax: (541) 346-4854. E-mail: stevens{at}molbio.uoregon.edu.

Microbiol Mol Biol Rev, March 1998, p. 230-247, Vol. 62, No. 1
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Mullock, B. M., Smith, C. W., Ihrke, G., Bright, N. A., Lindsay, M., Parkinson, E. J., Brooks, D. A., Parton, R. G., James, D. E., Luzio, J. P., Piper, R. C. (2000). Syntaxin 7 Is Localized to Late Endosome Compartments, Associates with Vamp 8, and Is Required for Late Endosome-Lysosome Fusion. Mol. Biol. Cell 11: 3137-3153 [Abstract] [Full Text]  
  • Seals, D. F., Eitzen, G., Margolis, N., Wickner, W. T., Price, A. (2000). A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc. Natl. Acad. Sci. USA 97: 9402-9407 [Abstract] [Full Text]  
  • Bassham, D. C., Sanderfoot, A. A., Kovaleva, V., Zheng, H., Raikhel, N. V. (2000). AtVPS45 Complex Formation at the trans-Golgi Network. Mol. Biol. Cell 11: 2251-2265 [Abstract] [Full Text]  
  • Wiederkehr, A., Avaro, S., Prescianotto-Baschong, C., Haguenauer-Tsapis, R., Riezman, H. (2000). The F-Box Protein Rcy1p Is Involved in Endocytic Membrane Traffic and Recycling Out of an Early Endosome in Saccharomyces cerevisiae. JCB 149: 397-410 [Abstract] [Full Text]  
  • Huang, W.-P., Scott, S. V., Kim, J., Klionsky, D. J. (2000). The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways. J. Biol. Chem. 275: 5845-5851 [Abstract] [Full Text]  
  • Nakamura, N., Yamamoto, A., Wada, Y., Futai, M. (2000). Syntaxin 7 Mediates Endocytic Trafficking to Late Endosomes. J. Biol. Chem. 275: 6523-6529 [Abstract] [Full Text]  
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  • Bensen, E. S., Costaguta, G., Payne, G. S. (2000). Synthetic Genetic Interactions With Temperature-Sensitive Clathrin in Saccharomyces cerevisiae: Roles for Synaptojanin-Like Inp53p and Dynamin-Related Vps1p in Clathrin-Dependent Protein Sorting at the trans-Golgi Network. Genetics 154: 83-97 [Abstract] [Full Text]  
  • Bishop, N., Woodman, P. (2000). ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking. Mol. Biol. Cell 11: 227-239 [Abstract] [Full Text]  
  • Decottignies, A., Owsianik, G., Ghislain, M. (1999). Casein Kinase I-dependent Phosphorylation and Stability of the Yeast Multidrug Transporter Pdr5p. J. Biol. Chem. 274: 37139-37146 [Abstract] [Full Text]  
  • Hama, H., Schnieders, E. A., Thorner, J., Takemoto, J. Y., DeWald, D. B. (1999). Direct Involvement of Phosphatidylinositol 4-Phosphate in Secretion in the Yeast Saccharomyces cerevisiae. J. Biol. Chem. 274: 34294-34300 [Abstract] [Full Text]  
  • Nass, R., Rao, R. (1999). The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock. Microbiology 145: 3221-3228 [Abstract] [Full Text]  
  • Yeung, B. G., Phan, H. L., Payne, G. S. (1999). Adaptor Complex-independent Clathrin Function in Yeast. Mol. Biol. Cell 10: 3643-3659 [Abstract] [Full Text]  
  • Sanderfoot, A. A., Kovaleva, V., Zheng, H., Raikhel, N. V. (1999). The t-SNARE AtVAM3p Resides on the Prevacuolar Compartment in Arabidopsis Root Cells. Plant Physiol. 121: 929-938 [Abstract] [Full Text]  
  • Horst, M., Knecht, E. C., Schu, P. V. (1999). Import into and Degradation of Cytosolic Proteins by Isolated Yeast Vacuoles. Mol. Biol. Cell 10: 2879-2889 [Abstract] [Full Text]  
  • Swaminathan, S., Amerik, A. Y., Hochstrasser, M. (1999). The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast. Mol. Biol. Cell 10: 2583-2594 [Abstract] [Full Text]  
  • Gaits, F., Russell, P. (1999). Vacuole Fusion Regulated by Protein Phosphatase 2C in Fission Yeast. Mol. Biol. Cell 10: 2647-2654 [Abstract] [Full Text]  
  • Vida, T., Gerhardt, B. (1999). A Cell-Free Assay Allows Reconstitution of Vps33p-Dependent Transport to the Yeast Vacuole/Lysosome. JCB 146: 85-98 [Abstract] [Full Text]  
  • Zheng, H., von Mollard, G. F., Kovaleva, V., Stevens, T. H., Raikhel, N. V. (1999). The Plant Vesicle-associated SNARE AtVTI1a Likely Mediates Vesicle Transport from the Trans-Golgi Network to the Prevacuolar Compartment. Mol. Biol. Cell 10: 2251-2264 [Abstract] [Full Text]  
  • von Mollard, G. F., Stevens, T. H. (1999). The Saccharomyces cerevisiae v-SNARE Vti1p Is Required for Multiple Membrane Transport Pathways to the Vacuole. Mol. Biol. Cell 10: 1719-1732 [Abstract] [Full Text]  
  • Kim, J., Dalton, V. M., Eggerton, K. P., Scott, S. V., Klionsky, D. J. (1999). Apg7p/Cvt2p Is Required for the Cytoplasm-to-Vacuole Targeting, Macroautophagy, and Peroxisome Degradation Pathways. Mol. Biol. Cell 10: 1337-1351 [Abstract] [Full Text]  
  • Mulholland, J., Konopka, J., Singer-Kruger, B., Zerial, M., Botstein, D. (1999). Visualization of Receptor-mediated Endocytosis in Yeast. Mol. Biol. Cell 10: 799-817 [Abstract] [Full Text]  
  • Miseta, A., Fu, L., Kellermayer, R., Buckley, J., Bedwell, D. M. (1999). The Golgi Apparatus Plays a Significant Role in the Maintenance of Ca2+ Homeostasis in the vps33Delta Vacuolar Biogenesis Mutant of Saccharomyces cerevisiae. J. Biol. Chem. 274: 5939-5947 [Abstract] [Full Text]  
  • Bryant, N. J., Piper, R. C., Weisman, L. S., Stevens, T. H. (1998). Retrograde Traffic Out of the Yeast Vacuole to the TGN Occurs via the Prevacuolar/Endosomal Compartment. JCB 142: 651-663 [Abstract] [Full Text]  
  • Legesse-Miller, A., Sagiv, Y., Glozman, R., Elazar, Z. (2000). Aut7p, a Soluble Autophagic Factor, Participates in Multiple Membrane Trafficking Processes. J. Biol. Chem. 275: 32966-32973 [Abstract] [Full Text]  
  • Yun, C.-W., Tiedeman, J. S., Moore, R. E., Philpott, C. C. (2000). Siderophore-Iron Uptake in Saccharomyces cerevisiae. IDENTIFICATION OF FERRICHROME AND FUSARININE TRANSPORTERS. J. Biol. Chem. 275: 16354-16359 [Abstract] [Full Text]  
  • Saiardi, A., Caffrey, J. J., Snyder, S. H., Shears, S. B. (2000). The Inositol Hexakisphosphate Kinase Family. CATALYTIC FLEXIBILITY AND FUNCTION IN YEAST VACUOLE BIOGENESIS. J. Biol. Chem. 275: 24686-24692 [Abstract] [Full Text]  
  • Phillips, S. A., Barr, V. A., Haft, D. H., Taylor, S. I., Haft, C. R. (2001). Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking. J. Biol. Chem. 276: 5074-5084 [Abstract] [Full Text]  
  • Bishop, N., Woodman, P. (2001). TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes. J. Biol. Chem. 276: 11735-11742 [Abstract] [Full Text]  
  • Dilcher, M., Kohler, B., von Mollard, G. F. (2001). Genetic Interactions with the Yeast Q-SNARE VTI1 Reveal Novel Functions for the R-SNARE YKT6. J. Biol. Chem. 276: 34537-34544 [Abstract] [Full Text]  
  • Shintani, T., Suzuki, K., Kamada, Y., Noda, T., Ohsumi, Y. (2001). Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure. J. Biol. Chem. 276: 30452-30460 [Abstract] [Full Text]  
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