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Microbiology and Molecular Biology Reviews, September 1998, p. 775-806, Vol. 62, No. 3
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Bacillus thuringiensis and Its Pesticidal Crystal Proteins

E. Schnepf,1 N. Crickmore,2 J. Van Rie,3 D. Lereclus,4 J. Baum,5 J. Feitelson,1 D. R. Zeigler,6 and D. H. Dean6,*

Mycogen Corp., San Diego, California 921211; School of Biological Sciences, University of Sussex, Brighton, United Kingdom2; Plant Genetic Systems, n.v., Ghent, Belgium3; Unité de Biochimie Microbienne, Institut Pasteur, Paris, France4; Ecogen, Inc., Langhorne, Pennsylvania 190475; and Department of Biochemistry, The Ohio State University, Columbus, Ohio 432106

During the past decade the pesticidal bacterium Bacillus thuringiensis has been the subject of intensive research. These efforts have yielded considerable data about the complex relationships between the structure, mechanism of action, and genetics of the organism's pesticidal crystal proteins, and a coherent picture of these relationships is beginning to emerge. Other studies have focused on the ecological role of the B. thuringiensis crystal proteins, their performance in agricultural and other natural settings, and the evolution of resistance mechanisms in target pests. Armed with this knowledge base and with the tools of modern biotechnology, researchers are now reporting promising results in engineering more-useful toxins and formulations, in creating transgenic plants that express pesticidal activity, and in constructing integrated management strategies to insure that these products are utilized with maximum efficiency and benefit.

* Corresponding author. Mailing address: Department of Biochemistry, 484 West Twelfth Ave., Columbus, OH 43210. Phone: (614) 292-8829. Fax: (614) 292-6773. E-mail: dean.10{at}osu.edu.

Microbiology and Molecular Biology Reviews, September 1998, p. 775-806, Vol. 62, No. 3
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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