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Microbiology and Molecular Biology Reviews, December 1998, p. 1191-1243, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae

Michael D. Mendenhall1,2,* and Amy E. Hodge1,3

L. P. Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-00961; Department of Biochemistry, University of Kentucky, Lexington, Kentucky 40536-00842; and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 065113

The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the most part, remain to be delineated, Cdc28 activity controls the timing of mitotic commitment, bud initiation, DNA replication, spindle formation, and chromosome separation. Environmental stimuli and progress through the cell cycle are monitored through checkpoint mechanisms that influence Cdc28 activity at key cell cycle stages. A vast body of information concerning how Cdc28 activity is timed and coordinated with various mitotic events has accrued. This article reviews that literature. Following an introduction to the properties of CDKs common to many eukaryotic species, the key influences on Cdc28 activity---cyclin-CKI binding and phosphorylation-dephosphorylation events---are examined. The processes controlling the abundance and activity of key Cdc28 regulators, especially transcriptional and proteolytic mechanisms, are then discussed in detail. Finally, the mechanisms by which environmental stimuli influence Cdc28 activity are summarized.

* Corresponding author. Mailing address: L. P. Markey Cancer Center, University of Kentucky, D. E. Combs Building, Room 212, 800 Rose St., Lexington, KY 40536-0096. Phone: (606) 257-5379. Fax: (606) 257-8940. E-mail: mendenh{at}pop.uky.edu.

Microbiology and Molecular Biology Reviews, December 1998, p. 1191-1243, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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