Posttranscriptional Control of Gene Expression in Yeast

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by McCarthy, J. E.咢.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by McCarthy, J. E.咢.

Microbiology and Molecular Biology Reviews, December 1998, p. 1492-1553, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Posttranscriptional Control of Gene Expression in Yeast

John E. G. McCarthy^*

Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology (UMIST), Manchester M60 1QD, United Kingdom

Studies of the budding yeast Saccharomyces cerevisiae have greatly advanced our understanding of the posttranscriptional stepsof eukaryotic gene expression. Given the wide range of experimentaltools applicable to S. cerevisiae and the recent determinationof its complete genomic sequence, many of the key challenges ofthe posttranscriptional control field can be tackled particularlyeffectively by using this organism. This article reviews the currentknowledge of the cellular components and mechanisms related totranslation and mRNA decay, with the emphasis on the molecularbasis for rate control and gene regulation. Recent progress incharacterizing translation factors and their protein-protein andRNA-protein interactions has been rapid. Against the backgroundof a growing body of structural information, the review discussesthe thermodynamic and kinetic principles that govern the translationprocess. As in prokaryotic systems, translational initiation isa key point of control. Modulation of the activities of translationalinitiation factors imposes global regulation in the cell, whilestructural features of particular 5' untranslated regions, suchas upstream open reading frames and effector binding sites, allowfor gene-specific regulation. Recent data have revealed many newdetails of the molecular mechanisms involved while providing insightinto the functional overlaps and molecular networking that areapparently a key feature of evolving cellular systems. An overallpicture of the mechanisms governing mRNA decay has only very recentlybegun to develop. The latest work has revealed new informationabout the mRNA decay pathways, the components of the mRNA degradationmachinery, and the way in which these might relate to the translationapparatus. Overall, major challenges still to be addressed includethe task of relating principles of posttranscriptional controlto cellular compartmentalization and polysome structure and therole of molecular channelling in these highly complex expressionsystems.

^* Mailing address: Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, UnitedKingdom. Phone: (44)161-200-8916. Fax: (44)161-200-8918. E-mail:J.McCarthy{at}umist.ac.uk.

Microbiology and Molecular Biology Reviews, December 1998, p. 1492-1553, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Puyaubert, J., Denis, L., Alban, C. (2008). Dual Targeting of Arabidopsis HOLOCARBOXYLASE SYNTHETASE1: A Small Upstream Open Reading Frame Regulates Translation Initiation and Protein Targeting. Plant Physiol. 146: 478-491 [Abstract] [Full Text]
Daran-Lapujade, P., Rossell, S., van Gulik, W. M., Luttik, M. A. H., de Groot, M. J. L., Slijper, M., Heck, A. J. R., Daran, J.-M., de Winde, J. H., Westerhoff, H. V., Pronk, J. T., Bakker, B. M. (2007). The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels. Proc. Natl. Acad. Sci. USA 104: 15753-15758 [Abstract] [Full Text]
Sangthong, P., Hughes, J., McCarthy, J. E. G. (2007). Distributed control for recruitment, scanning and subunit joining steps of translation initiation. Nucleic Acids Res 35: 3573-3580 [Abstract] [Full Text]
Gilbert, R. J. C., Gordiyenko, Y., von der Haar, T., Sonnen, A. F.-P., Hofmann, G., Nardelli, M., Stuart, D. I., McCarthy, J. E. G. (2007). Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex. Proc. Natl. Acad. Sci. USA 104: 5788-5793 [Abstract] [Full Text]
Babendure, J. R., Babendure, J. L., Ding, J.-H., Tsien, R. Y. (2006). Control of mammalian translation by mRNA structure near caps. RNA 12: 851-861 [Abstract] [Full Text]
Shababi, M., Bourque, J., Palanichelvam, K., Cole, A., Xu, D., Wan, X.-F., Schoelz, J. (2006). The ribosomal shunt translation strategy of cauliflower mosaic virus has evolved from ancient long terminal repeats.. J. Virol. 80: 3811-3822 [Abstract] [Full Text]
Rand, J. D., Grant, C. M. (2006). The Thioredoxin System Protects Ribosomes against Stress-induced Aggregation. Mol. Biol. Cell 17: 387-401 [Abstract] [Full Text]
Vasudevan, S., Garneau, N., Tu Khounh, D., Peltz, S. W. (2005). p38 Mitogen-Activated Protein Kinase/Hog1p Regulates Translation of the AU-Rich-Element-Bearing MFA2 Transcript. Mol. Cell. Biol. 25: 9753-9763 [Abstract] [Full Text]
Kuai, L., Das, B., Sherman, F. (2005). A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 102: 13962-13967 [Abstract] [Full Text]
Churbanov, A., Rogozin, I. B., Babenko, V. N., Ali, H., Koonin, E. V. (2005). Evolutionary conservation suggests a regulatory function of AUG triplets in 5'-UTRs of eukaryotic genes. Nucleic Acids Res 33: 5512-5520 [Abstract] [Full Text]
Steigele, S., Nieselt, K. (2005). Open reading frames provide a rich pool of potential natural antisense transcripts in fungal genomes. Nucleic Acids Res 33: 5034-5044 [Abstract] [Full Text]
Srikantha, T., Zhao, R., Daniels, K., Radke, J., Soll, D. R. (2005). Phenotypic Switching in Candida glabrata Accompanied by Changes in Expression of Genes with Deduced Functions in Copper Detoxification and Stress. Eukaryot Cell 4: 1434-1445 [Abstract] [Full Text]
Arava, Y., Boas, F. E., Brown, P. O., Herschlag, D. (2005). Dissecting eukaryotic translation and its control by ribosome density mapping. Nucleic Acids Res 33: 2421-2432 [Abstract] [Full Text]
Nasim, M. T., Trembath, R. C. (2005). A dual-light reporter system to determine the efficiency of protein-protein interactions in mammalian cells. Nucleic Acids Res 33: e66-e66 [Abstract] [Full Text]
Bjorkbacka, H., Fitzgerald, K. A., Huet, F., Li, X., Gregory, J. A., Lee, M. A., Ordija, C. M., Dowley, N. E., Golenbock, D. T., Freeman, M. W. (2005). The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol. Genomics 19: 319-330 [Abstract] [Full Text]
Malys, N., Carroll, K., Miyan, J., Tollervey, D., McCarthy, J. E. G. (2004). The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast. Nucleic Acids Res 32: 3590-3600 [Abstract] [Full Text]
BENARD, L. (2004). Inhibition of 5' to 3' mRNA degradation under stress conditions in Saccharomyces cerevisiae: from GCN4 to MET16. RNA 10: 458-468 [Abstract] [Full Text]
Shor, B., Calaycay, J., Rushbrook, J., McLeod, M. (2003). Cpc2/RACK1 Is a Ribosome-associated Protein That Promotes Efficient Translation in Schizosaccharomyces pombe. J. Biol. Chem. 278: 49119-49128 [Abstract] [Full Text]
Lieto, L. D., Borrego, F., You, C.-h., Coligan, J. E. (2003). Human CD94 Gene Expression: Dual Promoters Differing in Responsiveness to IL-2 or IL-15. J. Immunol. 171: 5277-5286 [Abstract] [Full Text]
Gardocki, M. E., Lopes, J. M. (2003). Expression of the Yeast PIS1 Gene Requires Multiple Regulatory Elements Including a Rox1p Binding Site. J. Biol. Chem. 278: 38646-38652 [Abstract] [Full Text]
Arava, Y., Wang, Y., Storey, J. D., Liu, C. L., Brown, P. O., Herschlag, D. (2003). Genome-wide analysis of mRNA translation profiles in Saccharomycescerevisiae. Proc. Natl. Acad. Sci. USA 100: 3889-3894 [Abstract] [Full Text]
Washburn, M. P., Koller, A., Oshiro, G., Ulaszek, R. R., Plouffe, D., Deciu, C., Winzeler, E., Yates, J. R. III (2003). Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomycescerevisiae. Proc. Natl. Acad. Sci. USA 100: 3107-3112 [Abstract] [Full Text]
Lee, J., Park, E. H., Couture, G., Harvey, I., Garneau, P., Pelletier, J. (2002). An upstream open reading frame impedes translation of the huntingtin gene. Nucleic Acids Res 30: 5110-5119 [Abstract] [Full Text]
Dunyak, D. S., Everdeen, D. S., Albanese, J. G., Quinn, C. L. (2002). Deletion of Individual mRNA Capping Genes Is Unexpectedly Not Lethal to Candida albicans and Results in Modified mRNA Cap Structures. Eukaryot Cell 1: 1010-1020 [Abstract] [Full Text]
Milone, J., Wilusz, J., Bellofatto, V. (2002). Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts. Nucleic Acids Res 30: 4040-4050 [Abstract] [Full Text]
Uesono, Y., Toh-e, A. (2002). Transient Inhibition of Translation Initiation by Osmotic Stress. J. Biol. Chem. 277: 13848-13855 [Abstract] [Full Text]
Griffin, T. J., Gygi, S. P., Ideker, T., Rist, B., Eng, J., Hood, L., Aebersold, R. (2002). Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae. Mol. Cell. Proteomics 1: 323-333 [Abstract] [Full Text]
Kim, M. J., Kim, J. B., Kim, D. S., Park, S. D. (2002). Glucose-inducible expression of rrg1+ in Schizosaccharomyces pombe: post-transcriptional regulation of mRNA stability mediated by the downstream region of the poly(A) site. Nucleic Acids Res 30: 1145-1153 [Abstract] [Full Text]
Shmulevitz, M., Yameen, Z., Dawe, S., Shou, J., O'Hara, D., Holmes, I., Duncan, R. (2002). Sequential Partially Overlapping Gene Arrangement in the Tricistronic S1 Genome Segments of Avian Reovirus and Nelson Bay Reovirus: Implications for Translation Initiation. J. Virol. 76: 609-618 [Abstract] [Full Text]
Vo, L. T. A., Minet, M., Schmitter, J.-M., Lacroute, F., Wyers, F. (2001). Mpe1, a Zinc Knuckle Protein, Is an Essential Component of Yeast Cleavage and Polyadenylation Factor Required for the Cleavage and Polyadenylation of mRNA. Mol. Cell. Biol. 21: 8346-8356 [Abstract] [Full Text]
Kozak, M. (2001). Constraints on reinitiation of translation in mammals. Nucleic Acids Res 29: 5226-5232 [Abstract] [Full Text]
Ptushkina, M., Berthelot, K., von der Haar, T., Geffers, L., Warwicker, J., McCarthy, J. E. G. (2001). A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties. Nucleic Acids Res 29: 4561-4569 [Abstract] [Full Text]
Thompson, S. R., Gulyas, K. D., Sarnow, P. (2001). Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element. Proc. Natl. Acad. Sci. USA 10.1073/pnas.241286698v1 [Abstract] [Full Text]
Paz, I., Choder, M. (2001). Eukaryotic Translation Initiation Factor 4E-Dependent Translation Is Not Essential for Survival of Starved Yeast Cells. J. Bacteriol. 183: 4477-4483 [Abstract] [Full Text]
Zhou, W., Edelman, G. M., Mauro, V. P. (2001). Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells. Proc. Natl. Acad. Sci. USA 98: 1531-1536 [Abstract] [Full Text]
Noueiry, A. O., Chen, J., Ahlquist, P. (2000). A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA. Proc. Natl. Acad. Sci. USA 10.1073/pnas.240460897v1 [Abstract] [Full Text]
Hemmings-Mieszczak, M., Hohn, T., Preiss, T. (2000). Termination and Peptide Release at the Upstream Open Reading Frame Are Required for Downstream Translation on Synthetic Shunt-Competent mRNA Leaders. Mol. Cell. Biol. 20: 6212-6223 [Abstract] [Full Text]
ter Kuile, B. H., Sallés, F. J. (2000). The Length of the Combined 3' Untranslated Region and Poly(A) Tail Does Not Control Rates of Glyceraldehyde-3-Phosphate Dehydrogenase mRNA Translation in Three Species of Parasitic Protists. J. Bacteriol. 182: 3587-3589 [Abstract] [Full Text]
Gale, M. Jr., Tan, S.-L., Katze, M. G. (2000). Translational Control of Viral Gene Expression in Eukaryotes. Microbiol. Mol. Biol. Rev. 64: 239-280 [Abstract] [Full Text]
Wyers, F., Minet, M., Dufour, M. E., Vo, L. T. A., Lacroute, F. (2000). Deletion of the PAT1 Gene Affects Translation Initiation and Suppresses a PAB1 Gene Deletion in Yeast. Mol. Cell. Biol. 20: 3538-3549 [Abstract] [Full Text]
Brown, J. T., Yang, X., Johnson, A. W. (2000). Inhibition of mRNA Turnover in Yeast by an xrn1 Mutation Enhances the Requirement for eIF4E Binding to eIF4G and for Proper Capping of Transcripts by Ceg1p. Genetics 155: 31-42 [Abstract] [Full Text]
Wang, Z., Gaba, A., Sachs, M. S. (1999). A Highly Conserved Mechanism of Regulated Ribosome Stalling Mediated by Fungal Arginine Attenuator Peptides That Appears Independent of the Charging Status of Arginyl-tRNAs. J. Biol. Chem. 274: 37565-37574 [Abstract] [Full Text]
ter Kuile, B. H. (1999). Regulation and Adaptation of Glucose Metabolism of the Parasitic Protist Leishmania donovani at the Enzyme and mRNA Levels. J. Bacteriol. 181: 4863-4872 [Abstract] [Full Text]
Paz, I., Abramovitz, L., Choder, M. (1999). Starved Saccharomyces cerevisiae Cells Have the Capacity to Support Internal Initiation of Translation. J. Biol. Chem. 274: 21741-21745 [Abstract] [Full Text]
Richter, J. D. (1999). Cytoplasmic Polyadenylation in Development and Beyond. Microbiol. Mol. Biol. Rev. 63: 446-456 [Abstract] [Full Text]
Hughes, J. M.詾., Ptushkina, M., Karim, Md. M., Koloteva, N., von der Haar, T., McCarthy, J. E.咢. (1999). Translational Repression by Human 4E-BP1 in Yeast Specifically Requires Human eIF4E as Target. J. Biol. Chem. 274: 3261-3264 [Abstract] [Full Text]
von der Haar, T., Ball, P. D., McCarthy, J. E. G. (2000). Stabilization of Eukaryotic Initiation Factor 4E Binding to the mRNA 5'-Cap by Domains of eIF4G. J. Biol. Chem. 275: 30551-30555 [Abstract] [Full Text]
Karim, M. M., Hughes, J. M. X., Warwicker, J., Scheper, G. C., Proud, C. G., McCarthy, J. E. G. (2001). A Quantitative Molecular Model for Modulation of Mammalian Translation by the eIF4E-binding Protein 1. J. Biol. Chem. 276: 20750-20757 [Abstract] [Full Text]
Xiao, X., Tang, Y.-S., Mackins, J. Y., Sun, X.-L., Jayaram, H. N., Hansen, D. K., Antony, A. C. (2001). Isolation and Characterization of a Folate Receptor mRNA-binding trans-Factor from Human Placenta. EVIDENCE FAVORING IDENTITY WITH HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E1. J. Biol. Chem. 276: 41510-41517 [Abstract] [Full Text]
Staib, P., Kretschmar, M., Nichterlein, T., Hof, H., Morschhauser, J. (2000). Differential activation of a Candida albicans virulence gene family during infection. Proc. Natl. Acad. Sci. USA 97: 6102-6107 [Abstract] [Full Text]
Noueiry, A. O., Chen, J., Ahlquist, P. (2000). A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA. Proc. Natl. Acad. Sci. USA 97: 12985-12990 [Abstract] [Full Text]
Thompson, S. R., Gulyas, K. D., Sarnow, P. (2001). Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element. Proc. Natl. Acad. Sci. USA 98: 12972-12977 [Abstract] [Full Text]

Appl. Environ. Microbiol.	Infect. Immun.	Eukaryot. Cell
Mol. Cell. Biol.	J. Virol.	J. Bacteriol.
	ALL ASM JOURNALS