This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richter, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richter, J. D.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, June 1999, p. 446-456, Vol. 63, No. 2
1092-2172/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cytoplasmic Polyadenylation in Development and Beyond

Joel D. Richter*

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both vertebrates and invertebrates, is essential for meiosis and body patterning. In spite of the evolutionary conservation of cytoplasmic polyadenylation, many of the cis elements and trans-acting factors appear to have some species specificity. With the recent isolation and cloning of factors involved in both poly(A) elongation and deadenylation, the underlying biochemistry of these reactions is beginning to be elucidated. In addition to early development, cytoplasmic polyadenylation is now known to occur in the adult brain, and there is circumstantial evidence that this process occurs at synapses, where it could mediate the long-lasting phase of long-term potentiation, which is probably the basis of learning and memory. Finally, there may be multiple mechanisms by which polyadenylation promotes translation. Important questions yet to be answered in the field of cytoplasmic polyadenylation are addressed.

* Mailing address: University of Massachusetts Medical School, Four Biotech, 377 Plantation St., Worcester, MA 01605. Phone: (508) 856-8615. Fax: (508) 856-8774. E-mail: Joel.Richter{at}ummed.edu.

Microbiology and Molecular Biology Reviews, June 1999, p. 446-456, Vol. 63, No. 2
1092-2172/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kandel, E. R. (2009). The Biology of Memory: A Forty-Year Perspective. J. Neurosci. 29: 12748-12756 [Abstract] [Full Text]  
  • Kimura, M., Ishida, K., Kashiwabara, S.-i., Baba, T. (2009). Characterization of Two Cytoplasmic Poly(A)-Binding Proteins, PABPC1 and PABPC2, in Mouse Spermatogenic Cells. Biol. Reprod. 80: 545-554 [Abstract] [Full Text]  
  • Lee, Y. S., Latham, K. E., VandeVoort, C. A. (2008). Effects of in vitro maturation on gene expression in rhesus monkey oocytes. Physiol. Genomics 35: 145-158 [Abstract] [Full Text]  
  • Guzeloglu-Kayisli, O., Pauli, S., Demir, H., Lalioti, M. D., Sakkas, D., Seli, E. (2008). Identification and characterization of human embryonic poly(A) binding protein (EPAB). Mol Hum Reprod 14: 581-588 [Abstract] [Full Text]  
  • Yamagata, K. (2008). Capturing Epigenetic Dynamics During Pre-implantation Development Using Live Cell Imaging. J Biochem 143: 279-286 [Abstract] [Full Text]  
  • Lee, S.-H., Choi, H.-S., Kim, H., Lee, Y. (2008). ERK is a novel regulatory kinase for poly(A) polymerase. Nucleic Acids Res 36: 803-813 [Abstract] [Full Text]  
  • Kosmidou, I., Moore, J. P., Weber, M., Searles, C. D. (2007). Statin Treatment and 3' Polyadenylation of eNOS mRNA. Arterioscler. Thromb. Vasc. Bio. 27: 2642-2649 [Abstract] [Full Text]  
  • Beerens, N., Selisko, B., Ricagno, S., Imbert, I., van der Zanden, L., Snijder, E. J., Canard, B. (2007). De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase. J. Virol. 81: 8384-8395 [Abstract] [Full Text]  
  • Brengues, M., Parker, R. (2007). Accumulation of Polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-Bodies in Saccharomyces cerevisiae. Mol. Biol. Cell 18: 2592-2602 [Abstract] [Full Text]  
  • Voltmer-Irsch, S., Kneissel, S., Adenot, P. G., Schmidt-Zachmann, M. S. (2007). Regulatory mechanisms governing the oocyte-specific synthesis of the karyoskeletal protein NO145. J. Cell Sci. 120: 1412-1422 [Abstract] [Full Text]  
  • Slevin, M. K., Gourronc, F., Hartley, R. S. (2007). ElrA binding to the 3'UTR of cyclin E1 mRNA requires polyadenylation elements. Nucleic Acids Res 35: 2167-2176 [Abstract] [Full Text]  
  • Liu, D., Brockman, J. M., Dass, B., Hutchins, L. N., Singh, P., McCarrey, J. R., MacDonald, C. C., Graber, J. H. (2007). Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis. Nucleic Acids Res 35: 234-246 [Abstract] [Full Text]  
  • Yoshino, O., McMahon, H. E., Sharma, S., Shimasaki, S. (2006). A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc. Natl. Acad. Sci. USA 103: 10678-10683 [Abstract] [Full Text]  
  • Moraes, K. C.M., Wilusz, C. J., Wilusz, J. (2006). CUG-BP binds to RNA substrates and recruits PARN deadenylase. RNA 12: 1084-1091 [Abstract] [Full Text]  
  • Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., Schier, A. F. (2006). Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs. Science 312: 75-79 [Abstract] [Full Text]  
  • Gomes, N. P., Bjerke, G., Llorente, B., Szostek, S. A., Emerson, B. M., Espinosa, J. M. (2006). Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.. Genes Dev. 20: 601-612 [Abstract] [Full Text]  
  • Vasudevan, S., Seli, E., Steitz, J. A. (2006). Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. Genes Dev. 20: 138-146 [Full Text]  
  • SCHIER, A.F., GIRALDEZ, A.J. (2006). MicroRNA Function and Mechanism: Insights from Zebra Fish. Cold Spring Harb Symp Quant Biol 71: 195-203 [Abstract]  
  • Chen, I-H., Chou, W.-J., Lee, P.-Y., Hsu, Y.-H., Tsai, C.-H. (2005). The AAUAAA Motif of Bamboo Mosaic Virus RNA Is Involved in Minus-Strand RNA Synthesis and Plus-Strand RNA Polyadenylation. J. Virol. 79: 14555-14561 [Abstract] [Full Text]  
  • Thompson, B. E., Bernstein, D. S., Bachorik, J. L., Petcherski, A. G., Wickens, M., Kimble, J. (2005). Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB. Development 132: 3471-3481 [Abstract] [Full Text]  
  • Weber, M., Hagedorn, C. H., Harrison, D. G., Searles, C. D. (2005). Laminar Shear Stress and 3' Polyadenylation of eNOS mRNA. Circ. Res. 96: 1161-1168 [Abstract] [Full Text]  
  • Tremblay, K., Vigneault, C., McGraw, S., Sirard, M.-A. (2005). Expression of Cyclin B1 Messenger RNA Isoforms and Initiation of Cytoplasmic Polyadenylation in the Bovine Oocyte. Biol. Reprod. 72: 1037-1044 [Abstract] [Full Text]  
  • Hema, M., Gopinath, K., Kao, C. (2005). Repair of the tRNA-Like CCA Sequence in a Multipartite Positive-Strand RNA Virus. J. Virol. 79: 1417-1427 [Abstract] [Full Text]  
  • Seli, E., Lalioti, M. D., Flaherty, S. M., Sakkas, D., Terzi, N., Steitz, J. A. (2005). An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proc. Natl. Acad. Sci. USA 102: 367-372 [Abstract] [Full Text]  
  • Leyens, G., Verhaeghe, B., Landtmeters, M., Marchandise, J., Knoops, B., Donnay, I. (2004). Peroxiredoxin 6 Is Upregulated in Bovine Oocytes and Cumulus Cells During In Vitro Maturation: Role of Intercellular Communication. Biol. Reprod. 71: 1646-1651 [Abstract] [Full Text]  
  • Choi, K. M., Barash, I., Rhoads, R. E. (2004). Insulin and Prolactin Synergistically Stimulate {beta}-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation. Mol. Endocrinol. 18: 1670-1686 [Abstract] [Full Text]  
  • Charlesworth, A., Cox, L. L., MacNicol, A. M. (2004). Cytoplasmic Polyadenylation Element (CPE)- and CPE-binding Protein (CPEB)-independent Mechanisms Regulate Early Class Maternal mRNA Translational Activation in Xenopus Oocytes. J. Biol. Chem. 279: 17650-17659 [Abstract] [Full Text]  
  • Fujimura, T., Esteban, R. (2004). Bipartite 3'-Cis-acting Signal for Replication in Yeast 23 S RNA Virus and Its Repair. J. Biol. Chem. 279: 13215-13223 [Abstract] [Full Text]  
  • SOLTER, D., HIIRAGI, T., EVSIKOV, A.V., MOYER, J., DE VRIES, W.N., PEASTON, A.E., KNOWLES, B.B. (2004). Epigenetic Mechanisms in Early Mammalian Development. Cold Spring Harb Symp Quant Biol 69: 11-18 [Abstract]  
  • Han, S., Xie, W., Hammes, S. R., DeJong, J. (2003). Expression of the Germ Cell-specific Transcription Factor ALF in Xenopus Oocytes Compensates for Translational Inactivation of the Somatic Factor TFIIA. J. Biol. Chem. 278: 45586-45593 [Abstract] [Full Text]  
  • Eads, B. D., Hand, S. C. (2003). Mitochondrial mRNA stability and polyadenylation during anoxia-induced quiescence in the brine shrimp Artemia franciscana. J. Exp. Biol. 206: 3681-3692 [Abstract] [Full Text]  
  • Park-Lee, S., Kim, S., Laird-Offringa, I. A. (2003). Characterization of the Interaction between Neuronal RNA-binding Protein HuD and AU-rich RNA. J. Biol. Chem. 278: 39801-39808 [Abstract] [Full Text]  
  • Watrin, E., Cubizolles, F., Osborne, H. B., Le Guellec, K., Legagneux, V. (2003). Expression and Functional Dynamics of the XCAP-D2 Condensin Subunit in Xenopus laevis Oocytes. J. Biol. Chem. 278: 25708-25715 [Abstract] [Full Text]  
  • Detivaud, L., Pascreau, G., Karaiskou, A., Osborne, H. B., Kubiak, J. Z. (2003). Regulation of EDEN-dependent deadenylation of Aurora A/Eg2-derived mRNA via phosphorylation and dephosphorylation in Xenopus laevis egg extracts. J. Cell Sci. 116: 2697-2705 [Abstract] [Full Text]  
  • Noueiry, A. O., Diez, J., Falk, S. P., Chen, J., Ahlquist, P. (2003). Yeast Lsm1p-7p/Pat1p Deadenylation-Dependent mRNA-Decapping Factors Are Required for Brome Mosaic Virus Genomic RNA Translation. Mol. Cell. Biol. 23: 4094-4106 [Abstract] [Full Text]  
  • Ogura, K.-i., Kishimoto, N., Mitani, S., Gengyo-Ando, K., Kohara, Y. (2003). Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans. Development 130: 2495-2503 [Abstract] [Full Text]  
  • Castagnetti, S., Ephrussi, A. (2003). Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte. Development 130: 835-843 [Abstract] [Full Text]  
  • BANERJEE, H., RAHN, A., DAVIS, W., SINGH, R. (2003). Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65) recognize polypyrimidine tracts using multiple modes of binding. RNA 9: 88-99 [Abstract] [Full Text]  
  • Choo, K.-B., Chen, H.-H., Liu, T. Y.-C., Chang, C.-P. (2002). Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos. Nucleic Acids Res 30: 4836-4844 [Abstract] [Full Text]  
  • Read, R. L., Martinho, R. G., Wang, S.-W., Carr, A. M., Norbury, C. J. (2002). Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc. Natl. Acad. Sci. USA 99: 12079-12084 [Abstract] [Full Text]  
  • Boucher, N., Wu, Y., Dumas, C., Dube, M., Sereno, D., Breton, M., Papadopoulou, B. (2002). A Common Mechanism of Stage-regulated Gene Expression in Leishmania Mediated by a Conserved 3'-Untranslated Region Element. J. Biol. Chem. 277: 19511-19520 [Abstract] [Full Text]  
  • Tomek, W., Sterza, F.A. M., Kubelka, M., Wollenhaupt, K., Torner, H., Anger, M., Kanitz, W. (2002). Regulation of Translation During In Vitro Maturation of Bovine Oocytes: The Role of MAP Kinase, eIF4E (Cap Binding Protein) Phosphorylation, and eIF4E-BP1. Biol. Reprod. 66: 1274-1282 [Abstract] [Full Text]  
  • Mansfield, J. H., Wilhelm, J. E., Hazelrigg, T. (2002). Ypsilon Schachtel, a Drosophila Y-box protein, acts antagonistically to Orb in the oskar mRNA localization and translation pathway. Development 129: 197-209 [Abstract] [Full Text]  
  • Ezzeddine, N., Paillard, L., Capri, M., Maniey, D., Bassez, T., Ait-Ahmed, O., Osborne, H. B. (2001). EDEN-dependent translational repression of maternal mRNAs is conserved between Xenopus and Drosophila. Proc. Natl. Acad. Sci. USA 10.1073/pnas.012555499v1 [Abstract] [Full Text]  
  • Aida, T., Oda, S., Awaji, T., Yoshida, K., Miyazaki, S. (2001). Expression of a green fluorescent protein variant in mouse oocytes by injection of RNA with an added long poly(A) tail. Mol Hum Reprod 7: 1039-1046 [Abstract] [Full Text]  
  • Chagnovich, D., Lehmann, R. (2001). Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 10.1073/pnas.201284398v1 [Abstract] [Full Text]  
  • Topalian, S. L., Kaneko, S., Gonzales, M. I., Bond, G. L., Ward, Y., Manley, J. L. (2001). Identification and Functional Characterization of Neo-Poly(A) Polymerase, an RNA Processing Enzyme Overexpressed in Human Tumors. Mol. Cell. Biol. 21: 5614-5623 [Abstract] [Full Text]  
  • Chang, J. S., Tan, L., Wolf, M. R., Schedl, P. (2001). Functioning of the Drosophila orb gene in gurken mRNA localization and translation. Development 128: 3169-3177 [Abstract] [Full Text]  
  • Fischer-Lougheed, J., Liu, J.-H., Espinos, E., Mordasini, D., Bader, C. R., Belin, D., Bernheim, L. (2001). Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels. JCB 153: 677-686 [Abstract] [Full Text]  
  • Voeltz, G. K., Ongkasuwan, J., Standart, N., Steitz, J. A. (2001). A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts. Genes Dev. 15: 774-788 [Abstract] [Full Text]  
  • GEBAUER, F., OSTARECK, D.H., OSTARECK-LEDERER, A., GRSKOVIC, M., HENTZE, M.W. (2001). Translational Control of 15-Lipoxygenase and msl-2 mRNAs: Single Regulators or Corepressor Assemblies?. Cold Spring Harb Symp Quant Biol 66: 329-336 [Abstract]  
  • Guan, H., Simon, A. E. (2000). Polymerization of nontemplate bases before transcription initiation at the 3' ends of templates by an RNA-dependent RNA polymerase: An activity involved in 3' end repair of viral RNAs. Proc. Natl. Acad. Sci. USA 97: 12451-12456 [Abstract] [Full Text]  
  • MIKULITS, W., PRADET-BALADE, B., HABERMANN, B., BEUG, H., GARCIA-SANZ, J. A., MÜLLNER, E. W. (2000). Isolation of translationally controlled mRNAs by differential screening. FASEB J. 14: 1641-1652 [Abstract] [Full Text]  
  • Adilakshmi, T., Ayling, P. D., Ratledge, C. (2000). Polyadenylylation in mycobacteria: evidence for oligo(dT)-primed cDNA synthesis. Microbiology 146: 633-638 [Abstract] [Full Text]  
  • Zhao, J., Hyman, L., Moore, C. (1999). Formation of mRNA 3' Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis. Microbiol. Mol. Biol. Rev. 63: 405-445 [Abstract] [Full Text]  
  • Martinez, J., Ren, Y.-G., Thuresson, A.-C., Hellman, U., Astrom, J., Virtanen, A. (2000). A 54-kDa Fragment of the Poly(A)-specific Ribonuclease Is an Oligomeric, Processive, and Cap-interacting Poly(A)-specific 3' Exonuclease. J. Biol. Chem. 275: 24222-24230 [Abstract] [Full Text]  
  • Kyriakopoulou, C. B., Nordvarg, H., Virtanen, A. (2001). A Novel Nuclear Human Poly(A) Polymerase (PAP), PAPgamma. J. Biol. Chem. 276: 33504-33511 [Abstract] [Full Text]  
  • Ezzeddine, N., Paillard, L., Capri, M., Maniey, D., Bassez, T., Ait-Ahmed, O., Osborne, H. B. (2002). EDEN-dependent translational repression of maternal mRNAs is conserved between Xenopus and Drosophila. Proc. Natl. Acad. Sci. USA 99: 257-262 [Abstract] [Full Text]  
  • Chagnovich, D., Lehmann, R. (2001). Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 98: 11359-11364 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»