This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seeger, C.
Right arrow Articles by Mason, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seeger, C.
Right arrow Articles by Mason, W. S.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, March 2000, p. 51-68, Vol. 64, No. 1
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Hepatitis B Virus Biology

Christoph Seeger* and William S. Mason

Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111

Hepadnaviruses (hepatitis B viruses) cause transient and chronic infections of the liver. Transient infections run a course of several months, and chronic infections are often lifelong. Chronic infections can lead to liver failure with cirrhosis and hepatocellular carcinoma. The replication strategy of these viruses has been described in great detail, but virus-host interactions leading to acute and chronic disease are still poorly understood. Studies on how the virus evades the immune response to cause prolonged transient infections with high-titer viremia and lifelong infections with an ongoing inflammation of the liver are still at an early stage, and the role of the virus in liver cancer is still elusive. The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future.

* Corresponding author. Mailing address: Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111. Phone: (215) 728-4312. Fax: (215) 728-4329. E-mail: c_seeger{at}fccc.edu.

Microbiology and Molecular Biology Reviews, March 2000, p. 51-68, Vol. 64, No. 1
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chua, P. K., Tang, F.-M., Huang, J.-Y., Suen, C.-S., Shih, C. (2010). Testing the Balanced Electrostatic Interaction Hypothesis of Hepatitis B Virus DNA Synthesis by Using an In Vivo Charge Rebalance Approach. J. Virol. 84: 2340-2351 [Abstract] [Full Text]  
  • Schulze, A., Schieck, A., Ni, Y., Mier, W., Urban, S. (2010). Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction. J. Virol. 84: 1989-2000 [Abstract] [Full Text]  
  • Weigand, K., Knaust, A., Schaller, H. (2010). Assembly and export determine the intracellular distribution of hepatitis B virus core protein subunits. J. Gen. Virol. 91: 59-67 [Abstract] [Full Text]  
  • Guo, H., Mao, R., Block, T. M., Guo, J.-T. (2010). Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses. J. Virol. 84: 387-396 [Abstract] [Full Text]  
  • Woltman, A M, Boonstra, A, Janssen, H L A (2010). Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?. Gut 59: 115-125 [Full Text]  
  • Zou, Y., Chen, T., Han, M., Wang, H., Yan, W., Song, G., Wu, Z., Wang, X., Zhu, C., Luo, X., Ning, Q. (2010). Increased Killing of Liver NK Cells by Fas/Fas Ligand and NKG2D/NKG2D Ligand Contributes to Hepatocyte Necrosis in Virus-Induced Liver Failure. J. Immunol. 184: 466-475 [Abstract] [Full Text]  
  • Ondracek, C. R., Rushing, C. N., Reese, V. C., Oropeza, C. E., McLachlan, A. (2009). Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1{alpha} and Small Heterodimer Partner Differentially Regulate Nuclear Receptor-Dependent Hepatitis B Virus Biosynthesis. J. Virol. 83: 12535-12544 [Abstract] [Full Text]  
  • Pairan, A., Bruss, V. (2009). Functional Surfaces of the Hepatitis B Virus Capsid. J. Virol. 83: 11616-11623 [Abstract] [Full Text]  
  • Garcia, T., Li, J., Sureau, C., Ito, K., Qin, Y., Wands, J., Tong, S. (2009). Drastic Reduction in the Production of Subviral Particles Does Not Impair Hepatitis B Virus Virion Secretion. J. Virol. 83: 11152-11165 [Abstract] [Full Text]  
  • Newman, M., Chua, P. K., Tang, F.-M., Su, P.-Y., Shih, C. (2009). Testing an Electrostatic Interaction Hypothesis of Hepatitis B Virus Capsid Stability by Using an In Vitro Capsid Disassembly/Reassembly System. J. Virol. 83: 10616-10626 [Abstract] [Full Text]  
  • Garcia, M. L., Byfield, R., Robek, M. D. (2009). Hepatitis B Virus Replication and Release Are Independent of Core Lysine Ubiquitination. J. Virol. 83: 4923-4933 [Abstract] [Full Text]  
  • Qin, J., Zhai, J., Hong, R., Shan, S., Kong, Y., Wen, Y., Wang, Y., Liu, J., Xie, Y. (2009). Prospero-related homeobox protein (Prox1) inhibits hepatitis B virus replication through repressing multiple cis regulatory elements. J. Gen. Virol. 90: 1246-1255 [Abstract] [Full Text]  
  • Hantz, O., Parent, R., Durantel, D., Gripon, P., Guguen-Guillouzo, C., Zoulim, F. (2009). Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells. J. Gen. Virol. 90: 127-135 [Abstract] [Full Text]  
  • Tchesnokov, E. P., Obikhod, A., Schinazi, R. F., Gotte, M. (2008). Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase. J. Biol. Chem. 283: 34218-34228 [Abstract] [Full Text]  
  • ELGOUHARI, H. M., ABU-RAJAB TAMIMI, T. I., CAREY, W. D. (2008). Hepatitis B virus infection: Understanding its epidemiology, course, and diagnosis. Cleveland Clinic Journal of Medicine 75: 881-889 [Abstract] [Full Text]  
  • Ramiere, C., Scholtes, C., Diaz, O., Icard, V., Perrin-Cocon, L., Trabaud, M.-A., Lotteau, V., Andre, P. (2008). Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXR{alpha}. J. Virol. 82: 10832-10840 [Abstract] [Full Text]  
  • Bourne, C., Lee, S., Venkataiah, B., Lee, A., Korba, B., Finn, M. G., Zlotnick, A. (2008). Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight into Virus Life Cycle. J. Virol. 82: 10262-10270 [Abstract] [Full Text]  
  • Lucifora, J., Durantel, D., Belloni, L., Barraud, L., Villet, S., Vincent, I. E., Margeridon-Thermet, S., Hantz, O., Kay, A., Levrero, M., Zoulim, F. (2008). Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector. J. Gen. Virol. 89: 1819-1828 [Abstract] [Full Text]  
  • Gudima, S., He, Y., Chai, N., Bruss, V., Urban, S., Mason, W., Taylor, J. (2008). Primary Human Hepatocytes Are Susceptible to Infection by Hepatitis Delta Virus Assembled with Envelope Proteins of Woodchuck Hepatitis Virus. J. Virol. 82: 7276-7283 [Abstract] [Full Text]  
  • Nguyen, D. H., Hu, J. (2008). Reverse Transcriptase- and RNA Packaging Signal-Dependent Incorporation of APOBEC3G into Hepatitis B Virus Nucleocapsids. J. Virol. 82: 6852-6861 [Abstract] [Full Text]  
  • Uetrecht, C., Versluis, C., Watts, N. R., Roos, W. H., Wuite, G. J. L., Wingfield, P. T., Steven, A. C., Heck, A. J. R. (2008). High-resolution mass spectrometry of viral assemblies: Molecular composition and stability of dimorphic hepatitis B virus capsids. Proc. Natl. Acad. Sci. USA 105: 9216-9220 [Abstract] [Full Text]  
  • Schwalbe, M., Ohlenschlager, O., Marchanka, A., Ramachandran, R., Hafner, S., Heise, T., Gorlach, M. (2008). Solution structure of stem-loop {alpha} of the hepatitis B virus post-transcriptional regulatory element. Nucleic Acids Res 36: 1681-1689 [Abstract] [Full Text]  
  • Grigoras, I., Timchenko, T., Gronenborn, B. (2008). Transcripts encoding the nanovirus master replication initiator proteins are terminally redundant. J. Gen. Virol. 89: 583-593 [Abstract] [Full Text]  
  • Stahl, M., Beck, J., Nassal, M. (2007). Chaperones Activate Hepadnavirus Reverse Transcriptase by Transiently Exposing a C-Proximal Region in the Terminal Protein Domain That Contributes to {varepsilon} RNA Binding. J. Virol. 81: 13354-13364 [Abstract] [Full Text]  
  • Wu, M., Xu, Y., Lin, S., Zhang, X., Xiang, L., Yuan, Z. (2007). Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1. J. Gen. Virol. 88: 3260-3269 [Abstract] [Full Text]  
  • Dougherty, A. M., Guo, H., Westby, G., Liu, Y., Simsek, E., Guo, J.-T., Mehta, A., Norton, P., Gu, B., Block, T., Cuconati, A. (2007). A Substituted Tetrahydro-Tetrazolo-Pyrimidine Is a Specific and Novel Inhibitor of Hepatitis B Virus Surface Antigen Secretion. Antimicrob. Agents Chemother. 51: 4427-4437 [Abstract] [Full Text]  
  • Guo, H., Jiang, D., Zhou, T., Cuconati, A., Block, T. M., Guo, J.-T. (2007). Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation. J. Virol. 81: 12472-12484 [Abstract] [Full Text]  
  • Tian, X., Zhao, C., Ren, J., Ma, Z.-M., Xie, Y.-H., Wen, Y.-M. (2007). Gene-expression profiles of a hepatitis B small surface antigen-secreting cell line reveal upregulation of lymphoid enhancer-binding factor 1. J. Gen. Virol. 88: 2966-2976 [Abstract] [Full Text]  
  • Zhu, Y., Curtis, M., Snow-Lampart, A., Yang, H., Delaney, W., Miller, M. D., Borroto-Esoda, K. (2007). In Vitro Drug Susceptibility Analysis of Hepatitis B Virus Clinical Quasispecies Populations. J. Clin. Microbiol. 45: 3335-3341 [Abstract] [Full Text]  
  • Guo, H., Zhou, T., Jiang, D., Cuconati, A., Xiao, G.-H., Block, T. M., Guo, J.-T. (2007). Regulation of Hepatitis B Virus Replication by the Phosphatidylinositol 3-Kinase-Akt Signal Transduction Pathway. J. Virol. 81: 10072-10080 [Abstract] [Full Text]  
  • Takenaka, K., Morgan, J. A., Scheffer, G. L., Adachi, M., Stewart, C. F., Sun, D., Leggas, M., Ejendal, K. F.K., Hrycyna, C. A., Schuetz, J. D. (2007). Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution. Cancer Res. 67: 6965-6972 [Abstract] [Full Text]  
  • Gao, W., Hu, J. (2007). Formation of Hepatitis B Virus Covalently Closed Circular DNA: Removal of Genome-Linked Protein. J. Virol. 81: 6164-6174 [Abstract] [Full Text]  
  • Blanchet, M., Sureau, C. (2007). Infectivity Determinants of the Hepatitis B Virus Pre-S Domain Are Confined to the N-Terminal 75 Amino Acid Residues. J. Virol. 81: 5841-5849 [Abstract] [Full Text]  
  • Nguyen, D. H., Gummuluru, S., Hu, J. (2007). Deamination-Independent Inhibition of Hepatitis B Virus Reverse Transcription by APOBEC3G. J. Virol. 81: 4465-4472 [Abstract] [Full Text]  
  • Langley, D. R., Walsh, A. W., Baldick, C. J., Eggers, B. J., Rose, R. E., Levine, S. M., Kapur, A. J., Colonno, R. J., Tenney, D. J. (2007). Inhibition of Hepatitis B Virus Polymerase by Entecavir. J. Virol. 81: 3992-4001 [Abstract] [Full Text]  
  • Noguchi, C., Hiraga, N., Mori, N., Tsuge, M., Imamura, M., Takahashi, S., Fujimoto, Y., Ochi, H., Abe, H., Maekawa, T., Yatsuji, H., Shirakawa, K., Takaori-Kondo, A., Chayama, K. (2007). Dual effect of APOBEC3G on Hepatitis B virus. J. Gen. Virol. 88: 432-440 [Abstract] [Full Text]  
  • Budhu, A., Wang, X. W. (2006). The role of cytokines in hepatocellular carcinoma. J. Leukoc. Biol. 80: 1197-1213 [Abstract] [Full Text]  
  • Bourne, C. R., Finn, M. G., Zlotnick, A. (2006). Global Structural Changes in Hepatitis B Virus Capsids Induced by the Assembly Effector HAP1. J. Virol. 80: 11055-11061 [Abstract] [Full Text]  
  • Shlomai, A., Paran, N., Shaul, Y. (2006). PGC-1{alpha} controls hepatitis B virus through nutritional signals. Proc. Natl. Acad. Sci. USA 103: 16003-16008 [Abstract] [Full Text]  
  • Park, S. G., Chung, C., Kang, H., Kim, J.-Y., Jung, G. (2006). Up-regulation of Cyclin D1 by HBx Is Mediated by NF-{kappa}B2/BCL3 Complex through {kappa}B Site of Cyclin D1 Promoter. J. Biol. Chem. 281: 31770-31777 [Abstract] [Full Text]  
  • Park, N H, Song, I H, Chung, Y-H (2006). Chronic hepatitis B in hepatocarcinogenesis.. Postgrad. Med. J. 82: 507-515 [Abstract] [Full Text]  
  • Bertoletti, A., Gehring, A. J. (2006). The immune response during hepatitis B virus infection. J. Gen. Virol. 87: 1439-1449 [Abstract] [Full Text]  
  • Rabe, B., Glebe, D., Kann, M. (2006). Lipid-Mediated Introduction of Hepatitis B Virus Capsids into Nonsusceptible Cells Allows Highly Efficient Replication and Facilitates the Study of Early Infection Events. J. Virol. 80: 5465-5473 [Abstract] [Full Text]  
  • Opi, S., Takeuchi, H., Kao, S., Khan, M. A., Miyagi, E., Goila-Gaur, R., Iwatani, Y., Levin, J. G., Strebel, K. (2006). Monomeric APOBEC3G Is Catalytically Active and Has Antiviral Activity. J. Virol. 80: 4673-4682 [Abstract] [Full Text]  
  • Hu, J., Boyer, M. (2006). Hepatitis B Virus Reverse Transcriptase and {varepsilon} RNA Sequences Required for Specific Interaction In Vitro. J. Virol. 80: 2141-2150 [Abstract] [Full Text]  
  • Heise, T., Sommer, G., Reumann, K., Meyer, I., Will, H., Schaal, H. (2006). The hepatitis B virus PRE contains a splicing regulatory element. Nucleic Acids Res 34: 353-363 [Abstract] [Full Text]  
  • Chen, B.-F., Liu, C.-J., Jow, G.-M., Chen, P.-J., Kao, J.-H., Chen, D.-S. (2006). Evolution of Hepatitis B virus in an acute hepatitis B patient co-infected with genotypes B and C. J. Gen. Virol. 87: 39-49 [Abstract] [Full Text]  
  • Guo, Y., Guo, H., Zhang, L., Xie, H., Zhao, X., Wang, F., Li, Z., Wang, Y., Ma, S., Tao, J., Wang, W., Zhou, Y., Yang, W., Cheng, J. (2005). Genomic Analysis of Anti-Hepatitis B Virus (HBV) Activity by Small Interfering RNA and Lamivudine in Stable HBV-Producing Cells. J. Virol. 79: 14392-14403 [Abstract] [Full Text]  
  • Tacke, F, Liedtke, C, Bocklage, S, Manns, M P, Trautwein, C (2005). CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter. Gut 54: 1309-1317 [Abstract] [Full Text]  
  • Wieland, S. F., Chisari, F. V. (2005). Stealth and Cunning: Hepatitis B and Hepatitis C Viruses. J. Virol. 79: 9369-9380 [Full Text]  
  • Barrera, A., Guerra, B., Notvall, L., Lanford, R. E. (2005). Mapping of the Hepatitis B Virus Pre-S1 Domain Involved in Receptor Recognition. J. Virol. 79: 9786-9798 [Abstract] [Full Text]  
  • Murakami, Y, Saigo, K, Takashima, H, Minami, M, Okanoue, T, Brechot, C, Paterlini-Brechot, P (2005). Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54: 1162-1168 [Abstract] [Full Text]  
  • Kimura, T., Ohno, N., Terada, N., Rokuhara, A., Matsumoto, A., Yagi, S., Tanaka, E., Kiyosawa, K., Ohno, S., Maki, N. (2005). Hepatitis B Virus DNA-negative Dane Particles Lack Core Protein but Contain a 22-kDa Precore Protein without C-terminal Arginine-rich Domain. J. Biol. Chem. 280: 21713-21719 [Abstract] [Full Text]  
  • Stray, S. J., Bourne, C. R., Punna, S., Lewis, W. G., Finn, M. G., Zlotnick, A. (2005). A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc. Natl. Acad. Sci. USA 102: 8138-8143 [Abstract] [Full Text]  
  • Tang, H., Delgermaa, L., Huang, F., Oishi, N., Liu, L., He, F., Zhao, L., Murakami, S. (2005). The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication. J. Virol. 79: 5548-5556 [Abstract] [Full Text]  
  • Zoulim, F. (2005). Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models. J Antimicrob Chemother 55: 608-611 [Abstract] [Full Text]  
  • Chen, A., Kao, Y. F., Brown, C. M. (2005). Translation of the first upstream ORF in the hepatitis B virus pregenomic RNA modulates translation at the core and polymerase initiation codons. Nucleic Acids Res 33: 1169-1181 [Abstract] [Full Text]  
  • Kuang, S.-Y., Lekawanvijit, S., Maneekarn, N., Thongsawat, S., Brodovicz, K., Nelson, K., Groopman, J. D. (2005). Hepatitis B 1762T/1764A Mutations, Hepatitis C Infection, and Codon 249 p53 Mutations in Hepatocellular Carcinomas from Thailand. Cancer Epidemiol. Biomarkers Prev. 14: 380-384 [Abstract] [Full Text]  
  • Gripon, P., Cannie, I., Urban, S. (2005). Efficient Inhibition of Hepatitis B Virus Infection by Acylated Peptides Derived from the Large Viral Surface Protein. J. Virol. 79: 1613-1622 [Abstract] [Full Text]  
  • Chou, Y.-C., Jeng, K.-S., Chen, M.-L., Liu, H.-H., Liu, T.-L., Chen, Y.-L., Liu, Y.-C., Hu, C.-p., Chang, C. (2005). Evaluation of Transcriptional Efficiency of Hepatitis B Virus Covalently Closed Circular DNA by Reverse Transcription-PCR Combined with the Restriction Enzyme Digestion Method. J. Virol. 79: 1813-1823 [Abstract] [Full Text]  
  • Le Pogam, S., Chua, P. K., Newman, M., Shih, C. (2005). Exposure of RNA Templates and Encapsidation of Spliced Viral RNA Are Influenced by the Arginine-Rich Domain of Human Hepatitis B Virus Core Antigen (HBcAg 165-173). J. Virol. 79: 1871-1887 [Abstract] [Full Text]  
  • O'Malley, B., Lazinski, D. W. (2005). Roles of Carboxyl-Terminal and Farnesylated Residues in the Functions of the Large Hepatitis Delta Antigen. J. Virol. 79: 1142-1153 [Abstract] [Full Text]  
  • Hasselblatt, P., Hockenjos, B., Thoma, C., Blum, H. E., Offensperger, W.-B. (2005). Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides. Nucleic Acids Res 33: 114-125 [Abstract] [Full Text]  
  • Vanlandschoot, P., Van Houtte, F., Serruys, B., Leroux-Roels, G. (2005). The arginine-rich carboxy-terminal domain of the hepatitis B virus core protein mediates attachment of nucleocapsids to cell-surface-expressed heparan sulfate. J. Gen. Virol. 86: 75-84 [Abstract] [Full Text]  
  • Kock, J., Nassal, M., Deres, K., Blum, H. E., von Weizsacker, F. (2004). Hepatitis B Virus Nucleocapsids Formed by Carboxy-Terminally Mutated Core Proteins Contain Spliced Viral Genomes but Lack Full-Size DNA. J. Virol. 78: 13812-13818 [Abstract] [Full Text]  
  • Hu, J., Flores, D., Toft, D., Wang, X., Nguyen, D. (2004). Requirement of Heat Shock Protein 90 for Human Hepatitis B Virus Reverse Transcriptase Function. J. Virol. 78: 13122-13131 [Abstract] [Full Text]  
  • Ehlers, I., Horke, S., Reumann, K., Rang, A., Grosse, F., Will, H., Heise, T. (2004). Functional Characterization of the Interaction between Human La and Hepatitis B Virus RNA. J. Biol. Chem. 279: 43437-43447 [Abstract] [Full Text]  
  • Rosler, C., Kock, J., Malim, M. H., Blum, H. E., von Weizsacker, F. (2004). Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G". Science 305: 1403a-1403a [Full Text]  
  • Ceres, P., Stray, S. J., Zlotnick, A. (2004). Hepatitis B Virus Capsid Assembly Is Enhanced by Naturally Occurring Mutation F97L. J. Virol. 78: 9538-9543 [Abstract] [Full Text]  
  • Wieland, S., Thimme, R., Purcell, R. H., Chisari, F. V. (2004). Genomic analysis of the host response to hepatitis B virus infection. Proc. Natl. Acad. Sci. USA 101: 6669-6674 [Abstract] [Full Text]  
  • Kuang, S.-Y., Jackson, P. E., Wang, J.-B., Lu, P.-X., Munoz, A., Qian, G.-S., Kensler, T. W., Groopman, J. D. (2004). Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc. Natl. Acad. Sci. USA 101: 3575-3580 [Abstract] [Full Text]  
  • Ostrow, K. M., Loeb, D. D. (2004). Underrepresentation of the 3' Region of the Capsid Pregenomic RNA of Duck Hepatitis B Virus. J. Virol. 78: 2179-2186 [Abstract] [Full Text]  
  • Wieland, S. F., Spangenberg, H. C., Thimme, R., Purcell, R. H., Chisari, F. V. (2004). Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees. Proc. Natl. Acad. Sci. USA 101: 2129-2134 [Abstract] [Full Text]  
  • Liu, N., Ji, L., Maguire, M. L., Loeb, D. D. (2004). cis-Acting Sequences That Contribute to the Synthesis of Relaxed-Circular DNA of Human Hepatitis B Virus. J. Virol. 78: 642-649 [Abstract] [Full Text]  
  • Lu, X., Tran, T., Simsek, E., Block, T. M. (2003). The Alkylated Imino Sugar, n-(n-Nonyl)-Deoxygalactonojirimycin, Reduces the Amount of Hepatitis B Virus Nucleocapsid in Tissue Culture. J. Virol. 77: 11933-11940 [Abstract] [Full Text]  
  • Park, S. G., Lee, S. M., Jung, G. (2003). Antisense Oligodeoxynucleotides Targeted against Molecular Chaperonin Hsp60 Block Human Hepatitis B Virus Replication. J. Biol. Chem. 278: 39851-39857 [Abstract] [Full Text]  
  • Rabe, B., Vlachou, A., Pante, N., Helenius, A., Kann, M. (2003). Nuclear import of hepatitis B virus capsids and release of the viral genome. Proc. Natl. Acad. Sci. USA 100: 9849-9854 [Abstract] [Full Text]  
  • Kock, J., Kann, M., Putz, G., Blum, H. E., von Weizsacker, F. (2003). Central Role of a Serine Phosphorylation Site within Duck Hepatitis B Virus Core Protein for Capsid Trafficking and Genome Release. J. Biol. Chem. 278: 28123-28129 [Abstract] [Full Text]  
  • Delelis, O., Saib, A., Sonigo, P. (2003). Biphasic DNA Synthesis in Spumaviruses. J. Virol. 77: 8141-8146 [Abstract] [Full Text]  
  • Norton, P. A., Gong, Q., Mehta, A. S., Lu, X., Block, T. M. (2003). Hepatitis B Virus-Mediated Changes of Apolipoprotein mRNA Abundance in Cultured Hepatoma Cells. J. Virol. 77: 5503-5506 [Abstract] [Full Text]  
  • Kamiya, N. (2003). The mechanisms of action of antivirals against hepatitis B virus infection. J Antimicrob Chemother 51: 1085-1089 [Full Text]  
  • Wang, X., Qian, X., Guo, H.-C., Hu, J. (2003). Heat Shock Protein 90-Independent Activation of Truncated Hepadnavirus Reverse Transcriptase. J. Virol. 77: 4471-4480 [Abstract] [Full Text]  
  • Karayiannis, P. (2003). Hepatitis B virus: old, new and future approaches to antiviral treatment. J Antimicrob Chemother 51: 761-785 [Abstract] [Full Text]  
  • Guo, J.-T., Pryce, M., Wang, X., Barrasa, M. I., Hu, J., Seeger, C. (2003). Conditional Replication of Duck Hepatitis B Virus in Hepatoma Cells. J. Virol. 77: 1885-1893 [Abstract] [Full Text]  
  • Prassolov, A., Hohenberg, H., Kalinina, T., Schneider, C., Cova, L., Krone, O., Frolich, K., Will, H., Sirma, H. (2003). New Hepatitis B Virus of Cranes That Has an Unexpected Broad Host Range. J. Virol. 77: 1964-1976 [Abstract] [Full Text]  
  • Mabit, H., Knaust, A., Breiner, K. M., Schaller, H. (2003). Nuclear Localization of the Duck Hepatitis B Virus Capsid Protein: Detection and Functional Implications of Distinct Subnuclear Bodies in a Compartment Associated with RNA Synthesis and Maturation. J. Virol. 77: 2157-2164 [Abstract] [Full Text]  
  • Suk, F.-M., Lin, M.-H., Newman, M., Pan, S., Chen, S.-H., Liu, J.-D., Shih, C. (2002). Replication Advantage and Host Factor-Independent Phenotypes Attributable to a Common Naturally Occurring Capsid Mutation (I97L) in Human Hepatitis B Virus. J. Virol. 76: 12069-12077 [Abstract] [Full Text]  
  • Ostrow, K. M., Loeb, D. D. (2002). Characterization of the cis-Acting Contributions to Avian Hepadnavirus RNA Encapsidation. J. Virol. 76: 9087-9095 [Abstract] [Full Text]  
  • Delaney, W. E. IV, Edwards, R., Colledge, D., Shaw, T., Furman, P., Painter, G., Locarnini, S. (2002). Phenylpropenamide Derivatives AT-61 and AT-130 Inhibit Replication of Wild-Type and Lamivudine-Resistant Strains of Hepatitis B Virus In Vitro. Antimicrob. Agents Chemother. 46: 3057-3060 [Abstract] [Full Text]  
  • Vanlandschoot, P., Van Houtte, F., Roobrouck, A., Farhoudi, A., Stelter, F., Peterson, D. L., Gomez-Gutierrez, J., Gavilanes, F., Leroux-Roels, G. (2002). LPS-binding protein and CD14-dependent attachment of hepatitis B surface antigen to monocytes is determined by the phospholipid moiety of the particles. J. Gen. Virol. 83: 2279-2289 [Abstract] [Full Text]  
  • Daub, H., Blencke, S., Habenberger, P., Kurtenbach, A., Dennenmoser, J., Wissing, J., Ullrich, A., Cotten, M. (2002). Identification of SRPK1 and SRPK2 as the Major Cellular Protein Kinases Phosphorylating Hepatitis B Virus Core Protein. J. Virol. 76: 8124-8137 [Abstract] [Full Text]  
  • Tang, H., McLachlan, A. (2002). Avian and Mammalian Hepadnaviruses Have Distinct Transcription Factor Requirements for Viral Replication. J. Virol. 76: 7468-7472 [Abstract] [Full Text]  
  • Wang, X., Grammatikakis, N., Hu, J. (2002). Role of p50/CDC37 in Hepadnavirus Assembly and Replication. J. Biol. Chem. 277: 24361-24367 [Abstract] [Full Text]  
  • Wang, X., Hu, J. (2002). Distinct Requirement for Two Stages of Protein-Primed Initiation of Reverse Transcription in Hepadnaviruses. J. Virol. 76: 5857-5865 [Abstract] [Full Text]  
  • Lopez, V. A., Bourne, E. J., Lutz, M. W., Condreay, L. D. (2002). Assessment of the COBAS Amplicor HBV Monitor Test for Quantitation of Serum Hepatitis B Virus DNA Levels. J. Clin. Microbiol. 40: 1972-1976 [Abstract] [Full Text]  
  • Zlotnick, A., Ceres, P., Singh, S., Johnson, J. M. (2002). A Small Molecule Inhibits and Misdirects Assembly of Hepatitis B Virus Capsids. J. Virol. 76: 4848-4854 [Abstract] [Full Text]  
  • Tralhao, J. G., Roudier, J., Morosan, S., Giannini, C., Tu, H., Goulenok, C., Carnot, F., Zavala, F., Joulin, V., Kremsdorf, D., Brechot, C. (2002). Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis. Proc. Natl. Acad. Sci. USA 99: 6991-6996 [Abstract] [Full Text]  
  • Mueller-Hill, K., Loeb, D. D. (2002). cis-Acting Sequences 5E, M, and 3E Interact To Contribute to Primer Translocation and Circularization during Reverse Transcription of Avian Hepadnavirus DNA. J. Virol. 76: 4260-4266 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»