Hepatitis B Virus Biology

doi:10.1128/MMBR.64.1.51-68.2000

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Microbiology and Molecular Biology Reviews, March 2000, p. 51-68, Vol. 64, No. 1
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Hepatitis B Virus Biology

Christoph Seeger^* and William S. Mason

Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111

Hepadnaviruses (hepatitis B viruses) cause transient and chronic infections of the liver. Transient infections run a courseof several months, and chronic infections are often lifelong.Chronic infections can lead to liver failure with cirrhosis andhepatocellular carcinoma. The replication strategy of these viruseshas been described in great detail, but virus-host interactionsleading to acute and chronic disease are still poorly understood.Studies on how the virus evades the immune response to cause prolongedtransient infections with high-titer viremia and lifelong infectionswith an ongoing inflammation of the liver are still at an earlystage, and the role of the virus in liver cancer is still elusive.The state of knowledge in this very active field is thereforereviewed with an emphasis on past accomplishments as well as goalsfor thefuture.

^* Corresponding author. Mailing address: Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111. Phone: (215) 728-4312.Fax: (215) 728-4329. E-mail: c_seeger{at}fccc.edu.

Microbiology and Molecular Biology Reviews, March 2000, p. 51-68, Vol. 64, No. 1
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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