This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sterner, D. E.
Right arrow Articles by Berger, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sterner, D. E.
Right arrow Articles by Berger, S. L.

 Previous Article

Microbiology and Molecular Biology Reviews, June 2000, p. 435-459, Vol. 64, No. 2
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Acetylation of Histones and Transcription-Related Factors

David E. Sterner and Shelley L. Berger*

The Wistar Institute, Philadelphia, Pennsylvania 19104

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to have major effects on levels of gene expression, and numerous chromatin-altering strategies---including ATP-dependent remodeling and histone modification---are employed in the cell to bring about transcriptional regulation. Of these, histone acetylation is one of the best characterized, as recent years have seen the identification and further study of many histone acetyltransferase (HAT) proteins and their associated complexes. Interestingly, most of these proteins were previously shown to have coactivator or other transcription-related functions. Confirmed and putative HAT proteins have been identified from various organisms from yeast to humans, and they include Gcn5-related N-acetyltransferase (GNAT) superfamily members Gcn5, PCAF, Elp3, Hpa2, and Hat1: MYST proteins Sas2, Sas3, Esa1, MOF, Tip60, MOZ, MORF, and HBO1; global coactivators p300 and CREB-binding protein; nuclear receptor coactivators SRC-1, ACTR, and TIF2; TATA-binding protein-associated factor TAFII250 and its homologs; and subunits of RNA polymerase III general factor TFIIIC. The acetylation and transcriptional functions of these HATs and the native complexes containing them (such as yeast SAGA, NuA4, and possibly analogous human complexes) are discussed. In addition, some of these HATs are also known to modify certain nonhistone transcription-related proteins, including high-mobility-group chromatin proteins, activators such as p53, coactivators, and general factors. Thus, we also detail these known factor acetyltransferase (FAT) substrates and the demonstrated or potential roles of their acetylation in transcriptional processes.

* Corresponding author. Mailing address: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3922. Fax: (215) 898-0663. E-mail: berger{at}wistar.upenn.edu.

Microbiology and Molecular Biology Reviews, June 2000, p. 435-459, Vol. 64, No. 2
1092-2172/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., Thompson, C. B. (2009). ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation. Science 324: 1076-1080 [Abstract] [Full Text]  
  • Wan, Y., Saleem, R. A., Ratushny, A. V., Roda, O., Smith, J. J., Lin, C.-H., Chiang, J.-H., Aitchison, J. D. (2009). Role of the Histone Variant H2A.Z/Htz1p in TBP Recruitment, Chromatin Dynamics, and Regulated Expression of Oleate-Responsive Genes. Mol. Cell. Biol. 29: 2346-2358 [Abstract] [Full Text]  
  • Bond, D. M., Dennis, E. S., Pogson, B. J., Finnegan, E. J. (2009). Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response. Mol Plant 0: ssp021v1-ssp021 [Abstract] [Full Text]  
  • Basheer, A., Berger, H., Reyes-Dominguez, Y., Gorfer, M., Strauss, J. (2009). A library-based method to rapidly analyse chromatin accessibility at multiple genomic regions. Nucleic Acids Res 37: e42-e42 [Abstract] [Full Text]  
  • Altman-Price, N., Mevarech, M. (2009). Genetic Evidence for the Importance of Protein Acetylation and Protein Deacetylation in the Halophilic Archaeon Haloferax volcanii. J. Bacteriol. 191: 1610-1617 [Abstract] [Full Text]  
  • Margariti, A., Xiao, Q., Zampetaki, A., Zhang, Z., Li, H., Martin, D., Hu, Y., Zeng, L., Xu, Q. (2009). Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells. J. Cell Sci. 122: 460-470 [Abstract] [Full Text]  
  • Bourguignon, L. Y. W., Xia, W., Wong, G. (2009). Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates {beta}-Catenin Signaling and NF{kappa}B-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells. J. Biol. Chem. 284: 2657-2671 [Abstract] [Full Text]  
  • Ge, X., Jin, Q., Zhang, F., Yan, T., Zhai, Q. (2009). PCAF Acetylates {beta}-Catenin and Improves Its Stability. Mol. Biol. Cell 20: 419-427 [Abstract] [Full Text]  
  • Manni, I., Caretti, G., Artuso, S., Gurtner, A., Emiliozzi, V., Sacchi, A., Mantovani, R., Piaggio, G. (2008). Posttranslational Regulation of NF-YA Modulates NF-Y Transcriptional Activity. Mol. Biol. Cell 19: 5203-5213 [Abstract] [Full Text]  
  • Ullah, M., Pelletier, N., Xiao, L., Zhao, S. P., Wang, K., Degerny, C., Tahmasebi, S., Cayrou, C., Doyon, Y., Goh, S.-L., Champagne, N., Cote, J., Yang, X.-J. (2008). Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes. Mol. Cell. Biol. 28: 6828-6843 [Abstract] [Full Text]  
  • Helmlinger, D., Marguerat, S., Villen, J., Gygi, S. P., Bahler, J., Winston, F. (2008). The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8. Genes Dev. 22: 3184-3195 [Abstract] [Full Text]  
  • Badri, K. R., Zhou, Y., Dhru, U., Aramgam, S., Schuger, L. (2008). Effects of the SANT Domain of Tension-Induced/Inhibited Proteins (TIPs), Novel Partners of the Histone Acetyltransferase p300, on p300 Activity and TIP-6-Induced Adipogenesis. Mol. Cell. Biol. 28: 6358-6372 [Abstract] [Full Text]  
  • Obrdlik, A., Kukalev, A., Louvet, E., Ostlund Farrants, A.-K., Caputo, L., Percipalle, P. (2008). The Histone Acetyltransferase PCAF Associates with Actin and hnRNP U for RNA Polymerase II Transcription. Mol. Cell. Biol. 28: 6342-6357 [Abstract] [Full Text]  
  • Tseng, C.-H., Jeng, K.-S., Lai, M. M. C. (2008). Transcription of Subgenomic mRNA of Hepatitis Delta Virus Requires a Modified Hepatitis Delta Antigen That Is Distinct from Antigenomic RNA Synthesis. J. Virol. 82: 9409-9416 [Abstract] [Full Text]  
  • Mertens, C., Roeder, R. G. (2008). Different Functional Modes of p300 in Activation of RNA Polymerase III Transcription from Chromatin Templates. Mol. Cell. Biol. 28: 5764-5776 [Abstract] [Full Text]  
  • Greene, D., Cagney, G., Krogan, N., Cunningham, P. (2008). Ensemble non-negative matrix factorization methods for clustering protein-protein interactions. Bioinformatics 24: 1722-1728 [Abstract] [Full Text]  
  • Liu, P.-Y., Chan, J. Y.-H., Lin, H.-C., Wang, S.-L., Liu, S.-T., Ho, C.-L., Chang, L.-C., Huang, S.-M. (2008). Modulation of the Cyclin-Dependent Kinase Inhibitor p21WAF1/Cip1 Gene by Zac1 through the Antagonistic Regulators p53 and Histone Deacetylase 1 in HeLa Cells. Mol Cancer Res 6: 1204-1214 [Abstract] [Full Text]  
  • Hattori, T., Coustry, F., Stephens, S., Eberspaecher, H., Takigawa, M., Yasuda, H., de Crombrugghe, B. (2008). Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res 36: 3011-3024 [Abstract] [Full Text]  
  • Zou, Y., Wu, J., Giannone, R. J., Boucher, L., Du, H., Huang, Y., Johnson, D. K., Liu, Y., Wang, Y. (2008). Nucleophosmin/B23 Negatively Regulates GCN5-dependent Histone Acetylation and Transactivation. J. Biol. Chem. 283: 5728-5737 [Abstract] [Full Text]  
  • Liu, X., Vorontchikhina, M., Wang, Y.-L., Faiola, F., Martinez, E. (2008). STAGA Recruits Mediator to the MYC Oncoprotein To Stimulate Transcription and Cell Proliferation. Mol. Cell. Biol. 28: 108-121 [Abstract] [Full Text]  
  • DeRan, M., Pulvino, M., Greene, E., Su, C., Zhao, J. (2008). Transcriptional Activation of Histone Genes Requires NPAT-Dependent Recruitment of TRRAP-Tip60 Complex to Histone Promoters during the G1/S Phase Transition. Mol. Cell. Biol. 28: 435-447 [Abstract] [Full Text]  
  • Gupta, A., Guerin-Peyrou, T. G., Sharma, G. G., Park, C., Agarwal, M., Ganju, R. K., Pandita, S., Choi, K., Sukumar, S., Pandita, R. K., Ludwig, T., Pandita, T. K. (2008). The Mammalian Ortholog of Drosophila MOF That Acetylates Histone H4 Lysine 16 Is Essential for Embryogenesis and Oncogenesis. Mol. Cell. Biol. 28: 397-409 [Abstract] [Full Text]  
  • Lalmansingh, A. S., Uht, R. M. (2008). Estradiol Regulates Corticotropin-Releasing Hormone Gene (crh) Expression in a Rapid and Phasic Manner that Parallels Estrogen Receptor-{alpha} and - Recruitment to a 3',5'-Cyclic Adenosine 5'-Monophosphate Regulatory Region of the Proximal crh Promoter. Endocrinology 149: 346-357 [Abstract] [Full Text]  
  • Groesdonk, H. V., Wagner, F., Hoffarth, B., Georgieff, M., Senftleben, U. (2007). Enhancement of NF-{kappa}B Activation in Lymphocytes Prevents T Cell Apoptosis and Improves Survival in Murine Sepsis. J. Immunol. 179: 8083-8089 [Abstract] [Full Text]  
  • Vallet-Gely, I., Sharp, J. S., Dove, S. L. (2007). Local and Global Regulators Linking Anaerobiosis to cupA Fimbrial Gene Expression in Pseudomonas aeruginosa. J. Bacteriol. 189: 8667-8676 [Abstract] [Full Text]  
  • Asano, Y., Czuwara, J., Trojanowska, M. (2007). Transforming Growth Factor- Regulates DNA Binding Activity of Transcription Factor Fli1 by p300/CREB-binding Protein-associated Factor-dependent Acetylation. J. Biol. Chem. 282: 34672-34683 [Abstract] [Full Text]  
  • Gillenwater, A. M., Zhong, M., Lotan, R. (2007). Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells. Molecular Cancer Therapeutics 6: 2967-2975 [Abstract] [Full Text]  
  • Wang, M., Gu, C., Qi, T., Tang, W., Wang, L., Wang, S., Zeng, X. (2007). BAF53 Interacts with p53 and Functions in p53-mediated p21-gene Transcription. J Biochem 142: 613-620 [Abstract] [Full Text]  
  • Zou, J., Marjanovic, J., Kisseleva, M. V., Wilson, M., Majerus, P. W. (2007). Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc. Natl. Acad. Sci. USA 104: 16834-16839 [Abstract] [Full Text]  
  • Cherasse, Y., Maurin, A.-C., Chaveroux, C., Jousse, C., Carraro, V., Parry, L., Deval, C., Chambon, C., Fafournoux, P., Bruhat, A. (2007). The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res 35: 5954-5965 [Abstract] [Full Text]  
  • Jiang, L., Smith, J. N., Anderson, S. L., Ma, P., Mizzen, C. A., Kelleher, N. L. (2007). Global Assessment of Combinatorial Post-translational Modification of Core Histones in Yeast Using Contemporary Mass Spectrometry: LYS4 TRIMETHYLATION CORRELATES WITH DEGREE OF ACETYLATION ON THE SAME H3 TAIL. J. Biol. Chem. 282: 27923-27934 [Abstract] [Full Text]  
  • Chi, Y.-H., Haller, K., Peloponese, J.-M. Jr., Jeang, K.-T. (2007). Histone Acetyltransferase hALP and Nuclear Membrane Protein hsSUN1 Function in De-condensation of Mitotic Chromosomes. J. Biol. Chem. 282: 27447-27458 [Abstract] [Full Text]  
  • Durant, M., Pugh, B. F. (2007). NuA4-Directed Chromatin Transactions throughout the Saccharomyces cerevisiae Genome. Mol. Cell. Biol. 27: 5327-5335 [Abstract] [Full Text]  
  • Hassan, M. Q., Tare, R., Lee, S. H., Mandeville, M., Weiner, B., Montecino, M., van Wijnen, A. J., Stein, J. L., Stein, G. S., Lian, J. B. (2007). HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes. Mol. Cell. Biol. 27: 3337-3352 [Abstract] [Full Text]  
  • Sharma, V. M., Tomar, R. S., Dempsey, A. E., Reese, J. C. (2007). Histone Deacetylases RPD3 and HOS2 Regulate the Transcriptional Activation of DNA Damage-Inducible Genes. Mol. Cell. Biol. 27: 3199-3210 [Abstract] [Full Text]  
  • Harms, K. L., Chen, X. (2007). Histone Deacetylase 2 Modulates p53 Transcriptional Activities through Regulation of p53-DNA Binding Activity. Cancer Res. 67: 3145-3152 [Abstract] [Full Text]  
  • Deng, W., Liu, C., Pei, Y., Deng, X., Niu, L., Cao, X. (2007). Involvement of the Histone Acetyltransferase AtHAC1 in the Regulation of Flowering Time via Repression of FLOWERING LOCUS C in Arabidopsis. Plant Physiol. 143: 1660-1668 [Abstract] [Full Text]  
  • Topper, M., Luo, Y., Zhadina, M., Mohammed, K., Smith, L., Muesing, M. A. (2007). Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication. J. Virol. 81: 3012-3017 [Abstract] [Full Text]  
  • Shim, E. Y., Hong, S. J., Oum, J.-H., Yanez, Y., Zhang, Y., Lee, S. E. (2007). RSC Mobilizes Nucleosomes To Improve Accessibility of Repair Machinery to the Damaged Chromatin. Mol. Cell. Biol. 27: 1602-1613 [Abstract] [Full Text]  
  • Zhu, X., Singh, N., Donnelly, C., Boimel, P., Elefant, F. (2007). The Cloning and Characterization of the Histone Acetyltransferase Human Homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 Is Essential for Multicellular Development. Genetics 175: 1229-1240 [Abstract] [Full Text]  
  • Bruhat, A., Cherasse, Y., Maurin, A.-C., Breitwieser, W., Parry, L., Deval, C., Jones, N., Jousse, C., Fafournoux, P. (2007). ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation. Nucleic Acids Res 35: 1312-1321 [Abstract] [Full Text]  
  • Wiper-Bergeron, N., Salem, H. A., Tomlinson, J. J., Wu, D., Hache, R. J. G. (2007). Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Proc. Natl. Acad. Sci. USA 104: 2703-2708 [Abstract] [Full Text]  
  • Gregoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J., Wong, J., Seto, E., Yang, X.-J. (2007). Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2. Mol. Cell. Biol. 27: 1280-1295 [Abstract] [Full Text]  
  • Samuel, L. P., Song, C.-H., Wei, J., Roberts, E. A., Dahl, J. L., Barry, C. E. III, Jo, E.-K., Friedman, R. L. (2007). Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion. Microbiology 153: 529-540 [Abstract] [Full Text]  
  • Grimaldi, B., Nakahata, Y., Sahar, S., Kaluzova, M., Gauthier, D., Pham, K., Patel, N., Hirayama, J., Sassone-Corsi, P. (2007). Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme. Cold Spring Harb Symp Quant Biol 72: 105-112 [Abstract]  
  • Ciurciu, A., Komonyi, O., Pankotai, T., Boros, I. M. (2006). The Drosophila Histone Acetyltransferase Gcn5 and Transcriptional Adaptor Ada2a Are Involved in Nucleosomal Histone H4 Acetylation. Mol. Cell. Biol. 26: 9413-9423 [Abstract] [Full Text]  
  • Yang, C. K., Kim, J. H., Stallcup, M. R. (2006). Role of the N-Terminal Activation Domain of the Coiled-Coil Coactivator in Mediating Transcriptional Activation by {beta}-Catenin. Mol. Endocrinol. 20: 3251-3262 [Abstract] [Full Text]  
  • Zhao, L.-J., Subramanian, T., Chinnadurai, G. (2006). Changes in C-terminal Binding Protein 2 (CtBP2) Corepressor Complex Induced by E1A and Modulation of E1A Transcriptional Activity by CtBP2. J. Biol. Chem. 281: 36613-36623 [Abstract] [Full Text]  
  • Mosley, A. J., Meekings, K. N., McCarthy, C., Shepherd, D., Cerundolo, V., Mazitschek, R., Tanaka, Y., Taylor, G. P., Bangham, C. R. (2006). Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection. Blood 108: 3801-3807 [Abstract] [Full Text]  
  • Benhamed, M., Bertrand, C., Servet, C., Zhou, D.-X. (2006). Arabidopsis GCN5, HD1, and TAF1/HAF2 Interact to Regulate Histone Acetylation Required for Light-Responsive Gene Expression. Plant Cell 18: 2893-2903 [Abstract] [Full Text]  
  • Guelman, S., Suganuma, T., Florens, L., Weake, V., Swanson, S. K., Washburn, M. P., Abmayr, S. M., Workman, J. L. (2006). The Essential Gene wda Encodes a WD40 Repeat Subunit of Drosophila SAGA Required for Histone H3 Acetylation.. Mol. Cell. Biol. 26: 7178-7189 [Abstract] [Full Text]  
  • Fukuda, H., Sano, N., Muto, S., Horikoshi, M. (2006). Simple histone acetylation plays a complex role in the regulation of gene expression.. Brief Funct Genomic Proteomic 5: 190-208 [Abstract] [Full Text]  
  • Verdone, L., Agricola, E., Caserta, M., Di Mauro, E. (2006). Histone acetylation in gene regulation. Brief Funct Genomic Proteomic 5: 209-221 [Abstract] [Full Text]  
  • Georgiakaki, M., Chabbert-Buffet, N., Dasen, B., Meduri, G., Wenk, S., Rajhi, L., Amazit, L., Chauchereau, A., Burger, C. W., Blok, L. J., Milgrom, E., Lombes, M., Guiochon-Mantel, A., Loosfelt, H. (2006). Ligand-Controlled Interaction of Histone Acetyltransferase Binding to ORC-1 (HBO1) with the N-Terminal Transactivating Domain of Progesterone Receptor Induces Steroid Receptor Coactivator 1-Dependent Coactivation of Transcription. Mol. Endocrinol. 20: 2122-2140 [Abstract] [Full Text]  
  • Gardner, J. G., Grundy, F. J., Henkin, T. M., Escalante-Semerena, J. C. (2006). Control of Acetyl-Coenzyme A Synthetase (AcsA) Activity by Acetylation/Deacetylation without NAD+ Involvement in Bacillus subtilis.. J. Bacteriol. 188: 5460-5468 [Abstract] [Full Text]  
  • Zhang, Y., Jiang, Y., Geiser, V., Zhou, J., Jones, C. (2006). Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity. J. Gen. Virol. 87: 1843-1851 [Abstract] [Full Text]  
  • Kim, M. Y., Woo, E. M., Chong, Y. T. E., Homenko, D. R., Kraus, W. L. (2006). Acetylation of Estrogen Receptor {alpha} by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor. Mol. Endocrinol. 20: 1479-1493 [Abstract] [Full Text]  
  • Melamed, P., Zhu, Y., Tan, S. H., Xie, M., Koh, M. (2006). Gonadotropin-Releasing Hormone Activation of C-jun, But Not Early Growth Response Factor-1, Stimulates Transcription of a Luteinizing Hormone {beta}-Subunit Gene. Endocrinology 147: 3598-3605 [Abstract] [Full Text]  
  • Hassan, A. H., Awad, S., Prochasson, P. (2006). The Swi2/Snf2 Bromodomain Is Required for the Displacement of SAGA and the Octamer Transfer of SAGA-acetylated Nucleosomes. J. Biol. Chem. 281: 18126-18134 [Abstract] [Full Text]  
  • Heltweg, B., Gatbonton, T., Schuler, A. D., Posakony, J., Li, H., Goehle, S., Kollipara, R., DePinho, R. A., Gu, Y., Simon, J. A., Bedalov, A. (2006). Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.. Cancer Res. 66: 4368-4377 [Abstract] [Full Text]  
  • Durant, M., Pugh, B. F. (2006). Genome-Wide Relationships between TAF1 and Histone Acetyltransferases in Saccharomyces cerevisiae.. Mol. Cell. Biol. 26: 2791-2802 [Abstract] [Full Text]  
  • Clarke, A. S., Samal, E., Pillus, L. (2006). Distinct Roles for the Essential MYST Family HAT Esa1p in Transcriptional Silencing. Mol. Biol. Cell 17: 1744-1757 [Abstract] [Full Text]  
  • Kobayashi, T., Wang, T., Maezawa, M., Kobayashi, M., Ohnishi, S., Hatanaka, K., Hige, S., Shimizu, Y., Kato, M., Asaka, M., Tanaka, J., Imamura, M., Hasegawa, K., Tanaka, Y., Brachmann, R. K. (2006). Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.. Cancer Res. 66: 3137-3144 [Abstract] [Full Text]  
  • Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. K., Mitra, S. (2006). Acetylation of Human 8-Oxoguanine-DNA Glycosylase by p300 and Its Role in 8-Oxoguanine Repair In Vivo.. Mol. Cell. Biol. 26: 1654-1665 [Abstract] [Full Text]  
  • Yang, Z., Cool, B. H., Martin, G. M., Hu, Q. (2006). A Dominant Role for FE65 (APBB1) in Nuclear Signaling. J. Biol. Chem. 281: 4207-4214 [Abstract] [Full Text]  
  • Ferreiro, J. A., Powell, N. G., Karabetsou, N., Mellor, J., Waters, R. (2006). Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene. Nucleic Acids Res 34: 976-985 [Abstract] [Full Text]  
  • Kasper, L. H., Fukuyama, T., Biesen, M. A., Boussouar, F., Tong, C., de Pauw, A., Murray, P. J., van Deursen, J. M. A., Brindle, P. K. (2006). Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development. Mol. Cell. Biol. 26: 789-809 [Abstract] [Full Text]  
  • Biswas, D., Yu, Y., Mitra, D., Stillman, D. J. (2006). Genetic Interactions Between Nhp6 and Gcn5 With Mot1 and the Ccr4-Not Complex That Regulate Binding of TATA-Binding Protein in Saccharomyces cerevisiae. Genetics 172: 837-849 [Abstract] [Full Text]  
  • Kim, J. H., Yang, C. K., Stallcup, M. R. (2006). Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA.. Nucleic Acids Res 34: 2736-2750 [Abstract] [Full Text]  
  • Bhatti, M. M., Livingston, M., Mullapudi, N., Sullivan, W. J. Jr. (2006). Pair of Unusual GCN5 Histone Acetyltransferases and ADA2 Homologues in the Protozoan Parasite Toxoplasma gondii. Eukaryot Cell 5: 62-76 [Abstract] [Full Text]  
  • Wang, Y.-N., Chen, Y.-J., Chang, W.-C. (2006). Activation of Extracellular Signal-Regulated Kinase Signaling by Epidermal Growth Factor Mediates c-Jun Activation and p300 Recruitment in Keratin 16 Gene Expression. Mol. Pharmacol. 69: 85-98 [Abstract] [Full Text]  
  • Ichijo, T., Voutetakis, A., Cotrim, A. P., Bhattachryya, N., Fujii, M., Chrousos, G. P., Kino, T. (2005). The Smad6-Histone Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: POTENTIAL CLINICAL IMPLICATIONS. J. Biol. Chem. 280: 42067-42077 [Abstract] [Full Text]  
  • Matheu, A., Klatt, P., Serrano, M. (2005). Regulation of the INK4a/ARF Locus by Histone Deacetylase Inhibitors. J. Biol. Chem. 280: 42433-42441 [Abstract] [Full Text]  
  • Hassa, P. O., Haenni, S. S., Buerki, C., Meier, N. I., Lane, W. S., Owen, H., Gersbach, M., Imhof, R., Hottiger, M. O. (2005). Acetylation of Poly(ADP-ribose) Polymerase-1 by p300/CREB-binding Protein Regulates Coactivation of NF-{kappa}B-dependent Transcription. J. Biol. Chem. 280: 40450-40464 [Abstract] [Full Text]  
  • Chen, W.-Y., Juan, L.-J., Chung, B.-c. (2005). SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding. Mol. Cell. Biol. 25: 10442-10453 [Abstract] [Full Text]  
  • Smith, A. T., Tucker-Samaras, S. D., Fairlamb, A. H., Sullivan, W. J. Jr. (2005). MYST Family Histone Acetyltransferases in the Protozoan Parasite Toxoplasma gondii. Eukaryot Cell 4: 2057-2065 [Abstract] [Full Text]  
  • Kimura, A., Matsubara, K., Horikoshi, M. (2005). A Decade of Histone Acetylation: Marking Eukaryotic Chromosomes with Specific Codes. J Biochem 138: 647-662 [Abstract] [Full Text]  
  • Gomez, E. B., Espinosa, J. M., Forsburg, S. L. (2005). Schizosaccharomyces pombe mst2+ Encodes a MYST Family Histone Acetyltransferase That Negatively Regulates Telomere Silencing. Mol. Cell. Biol. 25: 8887-8903 [Abstract] [Full Text]  
  • Chung, E. J., Lee, S., Sausville, E. A., Ryan, Q., Karp, J. E., Gojo, I., Telford, W. G., Lee, M.-J., Kong, H. S., Trepel, J. B. (2005). Histone Deacetylase Inhibitor Pharmacodynamic Analysis by Multiparameter Flow Cytometry. Annals of Clinical & Laboratory Science 35: 397-406 [Abstract] [Full Text]  
  • Archer, S. Y., Johnson, J., Kim, H.-J., Ma, Q., Mou, H., Daesety, V., Meng, S., Hodin, R. A. (2005). The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G696-G703 [Abstract] [Full Text]  
  • Dryer, R. L., Covey, L. R. (2005). A Novel NF-{kappa}B-Regulated Site within the Human I{gamma}1 Promoter Requires p300 for Optimal Transcriptional Activity. J. Immunol. 175: 4499-4507 [Abstract] [Full Text]  
  • Cleary, J., Sitwala, K. V., Khodadoust, M. S., Kwok, R. P. S., Mor-Vaknin, N., Cebrat, M., Cole, P. A., Markovitz, D. M. (2005). p300/CBP-associated Factor Drives DEK into Interchromatin Granule Clusters. J. Biol. Chem. 280: 31760-31767 [Abstract] [Full Text]  
  • Eichler, J., Adams, M. W. W. (2005). Posttranslational Protein Modification in Archaea. Microbiol. Mol. Biol. Rev. 69: 393-425 [Abstract] [Full Text]  
  • Swaminathan, V., Kishore, A. H., Febitha, K. K., Kundu, T. K. (2005). Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription. Mol. Cell. Biol. 25: 7534-7545 [Abstract] [Full Text]  
  • Xu, W.-S., Perez, G., Ngo, L., Gui, C.-Y., Marks, P. A. (2005). Induction of Polyploidy by Histone Deacetylase Inhibitor: A Pathway for Antitumor Effects. Cancer Res. 65: 7832-7839 [Abstract] [Full Text]  
  • Perrot, V., Rechler, M. M. (2005). The Coactivator p300 Directly Acetylates the Forkhead Transcription Factor Foxo1 and Stimulates Foxo1-Induced Transcription. Mol. Endocrinol. 19: 2283-2298 [Abstract] [Full Text]  
  • Dormeyer, W., Ott, M., Schnolzer, M. (2005). Probing Lysine Acetylation in Proteins: Strategies, Limitations, and Pitfalls of in Vitro Acetyltransferase Assays. Mol. Cell. Proteomics 4: 1226-1239 [Abstract] [Full Text]  
  • Wang, A. H., Gregoire, S., Zika, E., Xiao, L., Li, C. S., Li, H., Wright, K. L., Ting, J. P., Yang, X.-J. (2005). Identification of the Ankyrin Repeat Proteins ANKRA and RFXANK as Novel Partners of Class IIa Histone Deacetylases. J. Biol. Chem. 280: 29117-29127 [Abstract] [Full Text]  
  • Stribinskis, V., Heyman, H.-C., Ellis, S. R., Steffen, M. C., Martin, N. C. (2005). Rpm2p, a Component of Yeast Mitochondrial RNase P, Acts as a Transcriptional Activator in the Nucleus. Mol. Cell. Biol. 25: 6546-6558 [Abstract] [Full Text]  
  • Iseki, H., Shimizukawa, R., Sugiyama, F., Kunita, S., Iwama, A., Onodera, M., Nakauchi, H., Yagami, K.-i. (2005). Parvovirus Nonstructural Proteins Induce an Epigenetic Modification through Histone Acetylation in Host Genes and Revert Tumor Malignancy to Benignancy. J. Virol. 79: 8886-8893 [Abstract] [Full Text]  
  • Ozdemir, A., Spicuglia, S., Lasonder, E., Vermeulen, M., Campsteijn, C., Stunnenberg, H. G., Logie, C. (2005). Characterization of Lysine 56 of Histone H3 as an Acetylation Site in Saccharomyces cerevisiae. J. Biol. Chem. 280: 25949-25952 [Abstract] [Full Text]  
  • Starai, V. J., Gardner, J. G., Escalante-Semerena, J. C. (2005). Residue Leu-641 of Acetyl-CoA Synthetase is Critical for the Acetylation of Residue Lys-609 by the Protein Acetyltransferase Enzyme of Salmonella enterica. J. Biol. Chem. 280: 26200-26205 [Abstract] [Full Text]  
  • Kelly, S. N, McKenna, T J., Young, L. S (2005). Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex. J Endocrinol 186: 33-42 [Abstract] [Full Text]  
  • Guidez, F., Howell, L., Isalan, M., Cebrat, M., Alani, R. M., Ivins, S., Hormaeche, I., McConnell, M. J., Pierce, S., Cole, P. A., Licht, J., Zelent, A. (2005). Histone Acetyltransferase Activity of p300 Is Required for Transcriptional Repression by the Promyelocytic Leukemia Zinc Finger Protein. Mol. Cell. Biol. 25: 5552-5566 [Abstract] [Full Text]  
  • van Oevelen, C. J. C., van Teeffelen, H. A. A. M., Timmers, H. T. M. (2005). Differential Requirement of SAGA Subunits for Mot1p and Taf1p Recruitment in Gene Activation. Mol. Cell. Biol. 25: 4863-4872 [Abstract] [Full Text]  
  • Hilton, T. L., Li, Y., Dunphy, E. L., Wang, E. H. (2005). TAF1 Histone Acetyltransferase Activity in Sp1 Activation of the Cyclin D1 Promoter. Mol. Cell. Biol. 25: 4321-4332 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»