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Microbiology and Molecular Biology Reviews, June 2002, p. 300-372, Vol. 66, No. 2
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.2.300-372.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Osmotic Stress Signaling and Osmoadaptation in Yeasts

Stefan Hohmann*

Department of Cell and Molecular Biology/Microbiology, Göteborg University, S-405 30 Göteborg, Sweden

The ability to adapt to altered availability of free water is a fundamental property of living cells. The principles underlying osmoadaptation are well conserved. The yeast Saccharomyces cerevisiae is an excellent model system with which to study the molecular biology and physiology of osmoadaptation. Upon a shift to high osmolarity, yeast cells rapidly stimulate a mitogen-activated protein (MAP) kinase cascade, the high-osmolarity glycerol (HOG) pathway, which orchestrates part of the transcriptional response. The dynamic operation of the HOG pathway has been well studied, and similar osmosensing pathways exist in other eukaryotes. Protein kinase A, which seems to mediate a response to diverse stress conditions, is also involved in the transcriptional response program. Expression changes after a shift to high osmolarity aim at adjusting metabolism and the production of cellular protectants. Accumulation of the osmolyte glycerol, which is also controlled by altering transmembrane glycerol transport, is of central importance. Upon a shift from high to low osmolarity, yeast cells stimulate a different MAP kinase cascade, the cell integrity pathway. The transcriptional program upon hypo-osmotic shock seems to aim at adjusting cell surface properties. Rapid export of glycerol is an important event in adaptation to low osmolarity. Osmoadaptation, adjustment of cell surface properties, and the control of cell morphogenesis, growth, and proliferation are highly coordinated processes. The Skn7p response regulator may be involved in coordinating these events. An integrated understanding of osmoadaptation requires not only knowledge of the function of many uncharacterized genes but also further insight into the time line of events, their interdependence, their dynamics, and their spatial organization as well as the importance of subtle effects.

* Mailing address: Department of Cell and Molecular Biology/Microbiology, Göteborg, Sweden. Phone: (46 31) 773 2595. Fax: (46 31) 773 2599. E-mail: hohmann{at}gmm.gu.se.

Microbiology and Molecular Biology Reviews, June 2002, p. 300-372, Vol. 66, No. 2
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.2.300-372.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Vylkova, S., Jang, W. S., Li, W., Nayyar, N., Edgerton, M. (2007). Histatin 5 Initiates Osmotic Stress Response in Candida albicans via Activation of the Hog1 Mitogen-Activated Protein Kinase Pathway. Eukaryot Cell 6: 1876-1888 [Abstract] [Full Text]  
  • Zhao, X., Mehrabi, R., Xu, J.-R. (2007). Mitogen-Activated Protein Kinase Pathways and Fungal Pathogenesis. Eukaryot Cell 6: 1701-1714 [Full Text]  
  • Mollapour, M., Piper, P. W. (2007). Hog1 Mitogen-Activated Protein Kinase Phosphorylation Targets the Yeast Fps1 Aquaglyceroporin for Endocytosis, Thereby Rendering Cells Resistant to Acetic Acid. Mol. Cell. Biol. 27: 6446-6456 [Abstract] [Full Text]  
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  • Panadero, J., Hernandez-Lopez, M. J., Prieto, J. A., Randez-Gil, F. (2007). Overexpression of the Calcineurin Target CRZ1 Provides Freeze Tolerance and Enhances the Fermentative Capacity of Baker's Yeast. Appl. Environ. Microbiol. 73: 4824-4831 [Abstract] [Full Text]  
  • Fujioka, T., Mizutani, O., Furukawa, K., Sato, N., Yoshimi, A., Yamagata, Y., Nakajima, T., Abe, K. (2007). MpkA-Dependent and -Independent Cell Wall Integrity Signaling in Aspergillus nidulans. Eukaryot Cell 6: 1497-1510 [Abstract] [Full Text]  
  • Guha, N., Desai, P., Vancura, A. (2007). Plc1p Is Required for SAGA Recruitment and Derepression of Sko1p-regulated Genes. Mol. Biol. Cell 18: 2419-2428 [Abstract] [Full Text]  
  • Biswas, S., Van Dijck, P., Datta, A. (2007). Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans. Microbiol. Mol. Biol. Rev. 71: 348-376 [Abstract] [Full Text]  
  • Zapater, M., Sohrmann, M., Peter, M., Posas, F., de Nadal, E. (2007). Selective Requirement for SAGA in Hog1-Mediated Gene Expression Depending on the Severity of the External Osmostress Conditions. Mol. Cell. Biol. 27: 3900-3910 [Abstract] [Full Text]  
  • Loukin, S. H., Kung, C., Saimi, Y. (2007). Lipid perturbations sensitize osmotic down-shock activated Ca2+ influx, a yeast "deletome" analysis. FASEB J. 21: 1813-1820 [Abstract] [Full Text]  
  • Bettinger, B. T., Clark, M. G., Amberg, D. C. (2007). Requirement for the Polarisome and Formin Function in Ssk2p-Mediated Actin Recovery From Osmotic Stress in Saccharomyces cerevisiae. Genetics 175: 1637-1648 [Abstract] [Full Text]  
  • Hawle, P., Horst, D., Bebelman, J. P., Yang, X. X., Siderius, M., van der Vies, S. M. (2007). Cdc37p Is Required for Stress-Induced High-Osmolarity Glycerol and Protein Kinase C Mitogen-Activated Protein Kinase Pathway Functionality by Interaction with Hog1p and Slt2p (Mpk1p). Eukaryot Cell 6: 521-532 [Abstract] [Full Text]  
  • Gat-Viks, I., Shamir, R. (2007). Refinement and expansion of signaling pathways: The osmotic response network in yeast. Genome Res 17: 358-367 [Abstract] [Full Text]  
  • Liegeois, S., Benedetto, A., Michaux, G., Belliard, G., Labouesse, M. (2007). Genes Required for Osmoregulation and Apical Secretion in Caenorhabditis elegans. Genetics 175: 709-724 [Abstract] [Full Text]  
  • Wheeler, J. M., Thomas, J. H. (2006). Identification of a Novel Gene Family Involved in Osmotic Stress Response in Caenorhabditis elegans. Genetics 174: 1327-1336 [Abstract] [Full Text]  
  • Marques, J. M., Rodrigues, R. J., de Magalhaes-Sant'Ana, A. C., Goncalves, T. (2006). Saccharomyces cerevisiae Hog1 Protein Phosphorylation upon Exposure to Bacterial Endotoxin. J. Biol. Chem. 281: 24687-24694 [Abstract] [Full Text]  
  • Lamitina, T., Huang, C. G., Strange, K. (2006). Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc. Natl. Acad. Sci. USA 103: 12173-12178 [Abstract] [Full Text]  
  • Hernandez-Lopez, M. J., Randez-Gil, F., Prieto, J. A. (2006). Hog1 Mitogen-Activated Protein Kinase Plays Conserved and Distinct Roles in the Osmotolerant Yeast Torulaspora delbrueckii.. Eukaryot Cell 5: 1410-1419 [Abstract] [Full Text]  
  • Reiser, V., D'Aquino, K. E., Ee, L.-S., Amon, A. (2006). The Stress-activated Mitogen-activated Protein Kinase Signaling Cascade Promotes Exit from Mitosis. Mol. Biol. Cell 17: 3136-3146 [Abstract] [Full Text]  
  • Bahn, Y.-S., Kojima, K., Cox, G. M., Heitman, J. (2006). A Unique Fungal Two-Component System Regulates Stress Responses, Drug Sensitivity, Sexual Development, and Virulence of Cryptococcus neoformans. Mol. Biol. Cell 17: 3122-3135 [Abstract] [Full Text]  
  • Bhartiya, S., Chaudhary, N., Venkatesh, K.V, Doyle, F. J III (2006). Multiple feedback loop design in the tryptophan regulatory network of Escherichia coli suggests a paradigm for robust regulation of processes in series. J R Soc Interface 3: 383-391 [Abstract] [Full Text]  
  • Bonner, P. J., Shimkets, L. J. (2006). Cohesion-Defective Mutants of Myxococcus xanthus.. J. Bacteriol. 188: 4585-4588 [Abstract] [Full Text]  
  • Delgado-Jarana, J., Sousa, S., Gonzalez, F., Rey, M., Llobell, A. (2006). ThHog1 controls the hyperosmotic stress response in Trichoderma harzianum. Microbiology 152: 1687-1700 [Abstract] [Full Text]  
  • Monge, R. A., Roman, E., Nombela, C., Pla, J. (2006). The MAP kinase signal transduction network in Candida albicans.. Microbiology 152: 905-912 [Abstract] [Full Text]  
  • Liu, N.-A., Liu, Q., Wawrowsky, K., Yang, Z., Lin, S., Melmed, S. (2006). Prolactin Receptor Signaling Mediates the Osmotic Response of Embryonic Zebrafish Lactotrophs. Mol. Endocrinol. 20: 871-880 [Abstract] [Full Text]  
  • Hernandez-Lopez, M. J., Panadero, J., Prieto, J. A., Randez-Gil, F. (2006). Regulation of Salt Tolerance by Torulaspora delbrueckii Calcineurin Target Crz1p. Eukaryot Cell 5: 469-479 [Abstract] [Full Text]  
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  • Panadero, J., Pallotti, C., Rodriguez-Vargas, S., Randez-Gil, F., Prieto, J. A. (2006). A Downshift in Temperature Activates the High Osmolarity Glycerol (HOG) Pathway, Which Determines Freeze Tolerance in Saccharomyces cerevisiae. J. Biol. Chem. 281: 4638-4645 [Abstract] [Full Text]  
  • Strange, K., Denton, J., Nehrke, K. (2006). Ste20-Type Kinases: Evolutionarily Conserved Regulators of Ion Transport and Cell Volume. Physiology 21: 61-68 [Abstract] [Full Text]  
  • Enjalbert, B., Smith, D. A., Cornell, M. J., Alam, I., Nicholls, S., Brown, A. J.P., Quinn, J. (2006). Role of the Hog1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans. Mol. Biol. Cell 17: 1018-1032 [Abstract] [Full Text]  
  • Madrid, M., Soto, T., Khong, H. K., Franco, A., Vicente, J., Perez, P., Gacto, M., Cansado, J. (2006). Stress-induced Response, Localization, and Regulation of the Pmk1 Cell Integrity Pathway in Schizosaccharomyces pombe. J. Biol. Chem. 281: 2033-2043 [Abstract] [Full Text]  
  • Vaknin, A., Berg, H. C. (2006). Osmotic stress mechanically perturbs chemoreceptors in Escherichia coli. Proc. Natl. Acad. Sci. USA 103: 592-596 [Abstract] [Full Text]  
  • Guldener, U., Munsterkotter, M., Oesterheld, M., Pagel, P., Ruepp, A., Mewes, H.-W., Stumpflen, V. (2006). MPact: the MIPS protein interaction resource on yeast. Nucleic Acids Res 34: D436-D441 [Abstract] [Full Text]  
  • Santos, A., del Mar Alvarez, M., Mauro, M. S., Abrusci, C., Marquina, D. (2005). The Transcriptional Response of Saccharomyces cerevisiae to Pichia membranifaciens Killer Toxin. J. Biol. Chem. 280: 41881-41892 [Abstract] [Full Text]  
  • Roman, E., Nombela, C., Pla, J. (2005). The Sho1 Adaptor Protein Links Oxidative Stress to Morphogenesis and Cell Wall Biosynthesis in the Fungal Pathogen Candida albicans. Mol. Cell. Biol. 25: 10611-10627 [Abstract] [Full Text]  
  • Queralt, E., Igual, J. C. (2005). Functional Connection Between the Clb5 Cyclin, the Protein Kinase C Pathway and the Swi4 Transcription Factor in Saccharomyces cerevisiae. Genetics 171: 1485-1498 [Abstract] [Full Text]  
  • Zanelli, C. F., Valentini, S. R. (2005). Pkc1 Acts Through Zds1 and Gic1 to Suppress Growth and Cell Polarity Defects of a Yeast eIF5A Mutant. Genetics 171: 1571-1581 [Abstract] [Full Text]  
  • Kogej, T., Ramos, J., Plemenitas, A., Gunde-Cimerman, N. (2005). The Halophilic Fungus Hortaea werneckii and the Halotolerant Fungus Aureobasidium pullulans Maintain Low Intracellular Cation Concentrations in Hypersaline Environments. Appl. Environ. Microbiol. 71: 6600-6605 [Abstract] [Full Text]  
  • Perez-Torrado, R., Bruno-Barcena, J. M., Matallana, E. (2005). Monitoring Stress-Related Genes during the Process of Biomass Propagation of Saccharomyces cerevisiae Strains Used for Wine Making. Appl. Environ. Microbiol. 71: 6831-6837 [Abstract] [Full Text]  
  • Yoshimi, A., Kojima, K., Takano, Y., Tanaka, C. (2005). Group III Histidine Kinase Is a Positive Regulator of Hog1-Type Mitogen-Activated Protein Kinase in Filamentous Fungi. Eukaryot Cell 4: 1820-1828 [Abstract] [Full Text]  
  • Nittler, M. P., Hocking-Murray, D., Foo, C. K., Sil, A. (2005). Identification of Histoplasma capsulatum Transcripts Induced in Response to Reactive Nitrogen Species. Mol. Biol. Cell 16: 4792-4813 [Abstract] [Full Text]  
  • Hoffmann, X.-K., Beck, C. F. (2005). Mating-Induced Shedding of Cell Walls, Removal of Walls from Vegetative Cells, and Osmotic Stress Induce Presumed Cell Wall Genes in Chlamydomonas. Plant Physiol. 139: 999-1014 [Abstract] [Full Text]  
  • Kayingo, G., Wong, B. (2005). The MAP kinase Hog1p differentially regulates stress-induced production and accumulation of glycerol and D-arabitol in Candida albicans. Microbiology 151: 2987-2999 [Abstract] [Full Text]  


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