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Microbiology and Molecular Biology Reviews, September 2002, p. 447-459, Vol. 66, No. 3
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.3.447-459.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Relationship between Secondary Metabolism and Fungal Development

Ana M. Calvo,1 Richard A. Wilson,2 Jin Woo Bok,2 and Nancy P. Keller2*

Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115,1 Department of Plant Pathology, University of Wisconsin—Madison, Madison, Wisconsin 537062

Filamentous fungi are unique organisms—rivaled only by actinomycetes and plants—in producing a wide range of natural products called secondary metabolites. These compounds are very diverse in structure and perform functions that are not always known. However, most secondary metabolites are produced after the fungus has completed its initial growth phase and is beginning a stage of development represented by the formation of spores. In this review, we describe secondary metabolites produced by fungi that act as sporogenic factors to influence fungal development, are required for spore viability, or are produced at a time in the life cycle that coincides with development. We describe environmental and genetic factors that can influence the production of secondary metabolites. In the case of the filamentous fungus Aspergillus nidulans, we review the only described work that genetically links the sporulation of this fungus to the production of the mycotoxin sterigmatocystin through a shared G-protein signaling pathway.

* Corresponding author. Mailing address: Department of Plant Pathology, University of Wisconsin—Madison, Madison, WI 53706. Phone: (608) 262-9795. Fax: (608) 263-2626. E-mail: npk{at}plantpath.wisc.edu.

Microbiology and Molecular Biology Reviews, September 2002, p. 447-459, Vol. 66, No. 3
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.3.447-459.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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