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Microbiology and Molecular Biology Reviews, December 2002, p. 579-591, Vol. 66, No. 4
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.4.579-591.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

José L. Crespo and Michael N. Hall*

Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland

TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

* Corresponding author. Mailing address: Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. Phone: 41 61 267 2150. Fax: 41 61 267 2149. E-mail: M.Hall{at}unibas.ch.

Microbiology and Molecular Biology Reviews, December 2002, p. 579-591, Vol. 66, No. 4
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.4.579-591.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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