This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chazal, N.
Right arrow Articles by Gerlier, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chazal, N.
Right arrow Articles by Gerlier, D.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, June 2003, p. 226-237, Vol. 67, No. 2
1092-2172/03/$08.00+0     DOI: 10.1128/MMBR.67.2.226-237.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Virus Entry, Assembly, Budding, and Membrane Rafts

Nathalie Chazal1* and Denis Gerlier2

Immunologie-Virologie, EA 3038, Université Paul Sabatier, 31062 Toulouse,1 Immunité & Infections Virales, CNRS-UCBL UMR 5537, IFR Laennec, 69372 Lyon Cedex 08, France2

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries for completion of their replication cycle. The recent discovery of the heterogeneous distribution of the various lipids within cell membranes has led to the proposal that sphingolipids and cholesterol tend to segregate in microdomains called membrane rafts. The involvement of membrane rafts in biosynthetic traffic, signal transduction, and endocytosis has suggested that viruses may also take advantage of rafts for completion of some steps of their replication cycle, such as entry into their cell host, assembly, and budding. In this review, we have attempted to delineate all the reliable data sustaining this hypothesis and to build some models of how rafts are used as platforms for assembly of some viruses. Indeed, if in many cases a formal proof of raft involvement in a virus replication cycle is still lacking, one can reasonably suggest that, owing to their ability to specifically attract some proteins, lipid microdomains provide a particular milieu suitable for increasing the efficiency of many protein-protein interactions which are crucial for virus infection and growth.

* Corresponding author. Mailing address: Immuno-Virologie. EA 3038. Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France. Phone: (33) 5 61 55 86 06. Fax: (33) 5 61 55 86 06. E-mail: chazal{at}cict.fr.

Microbiology and Molecular Biology Reviews, June 2003, p. 226-237, Vol. 67, No. 2
1092-2172/03/$08.00+0     DOI: 10.1128/MMBR.67.2.226-237.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Taylor, J. M., Brown, M., Nejmeddine, M., Kim, K. J., Ratner, L., Lairmore, M., Nicot, C. (2009). Novel Role for Interleukin-2 Receptor-Jak Signaling in Retrovirus Transmission. J. Virol. 83: 11467-11476 [Abstract] [Full Text]  
  • Ursell, T. S., Klug, W. S., Phillips, R. (2009). Morphology and interaction between lipid domains. Proc. Natl. Acad. Sci. USA 106: 13301-13306 [Abstract] [Full Text]  
  • Raffaele, S., Bayer, E., Lafarge, D., Cluzet, S., German Retana, S., Boubekeur, T., Leborgne-Castel, N., Carde, J.-P., Lherminier, J., Noirot, E., Satiat-Jeunemaitre, B., Laroche-Traineau, J., Moreau, P., Ott, T., Maule, A. J., Reymond, P., Simon-Plas, F., Farmer, E. E., Bessoule, J.-J., Mongrand, S. (2009). Remorin, a Solanaceae Protein Resident in Membrane Rafts and Plasmodesmata, Impairs Potato virus X Movement. Plant Cell 21: 1541-1555 [Abstract] [Full Text]  
  • Boesze-Battaglia, K., Brown, A., Walker, L., Besack, D., Zekavat, A., Wrenn, S., Krummenacher, C., Shenker, B. J. (2009). Cytolethal Distending Toxin-induced Cell Cycle Arrest of Lymphocytes Is Dependent upon Recognition and Binding to Cholesterol. J. Biol. Chem. 284: 10650-10658 [Abstract] [Full Text]  
  • Hatch, S. C., Archer, J., Gummuluru, S. (2009). Glycosphingolipid Composition of Human Immunodeficiency Virus Type 1 (HIV-1) Particles Is a Crucial Determinant for Dendritic Cell-Mediated HIV-1 trans-Infection. J. Virol. 83: 3496-3506 [Abstract] [Full Text]  
  • Izquierdo-Useros, N., Naranjo-Gomez, M., Archer, J., Hatch, S. C., Erkizia, I., Blanco, J., Borras, F. E., Puertas, M. C., Connor, J. H., Fernandez-Figueras, M. T., Moore, L., Clotet, B., Gummuluru, S., Martinez-Picado, J. (2009). Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood 113: 2732-2741 [Abstract] [Full Text]  
  • Money, V. A., McPhee, H. K., Mosely, J. A., Sanderson, J. M., Yeo, R. P. (2009). Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction. Proc. Natl. Acad. Sci. USA 106: 4441-4446 [Abstract] [Full Text]  
  • Clemente, R., de Parseval, A., Perez, M., de la Torre, J. C. (2009). Borna Disease Virus Requires Cholesterol in both Cellular Membrane and Viral Envelope for Efficient Cell Entry. J. Virol. 83: 2655-2662 [Abstract] [Full Text]  
  • Chen, S. S.-L., Yang, P., Ke, P.-Y., Li, H.-F., Chan, W.-E., Chang, D.-K., Chuang, C.-K., Tsai, Y., Huang, S.-C. (2009). Identification of the LWYIK Motif Located in the Human Immunodeficiency Virus Type 1 Transmembrane gp41 Protein as a Distinct Determinant for Viral Infection. J. Virol. 83: 870-883 [Abstract] [Full Text]  
  • Chang, Y.-S., Liu, W.-J., Chou, T.-L., Lee, Y.-T., Lee, T.-L., Huang, W.-T., Kou, G.-H., Lo, C.-F. (2008). Characterization of White Spot Syndrome Virus Envelope Protein VP51A and Its Interaction with Viral Tegument Protein VP26. J. Virol. 82: 12555-12564 [Abstract] [Full Text]  
  • Oura, T., Kajiwara, S. (2008). Disruption of the sphingolipid {Delta}8-desaturase gene causes a delay in morphological changes in Candida albicans. Microbiology 154: 3795-3803 [Abstract] [Full Text]  
  • Pu, Y., Zhang, X. (2008). Mouse Hepatitis Virus Type 2 Enters Cells through a Clathrin-Mediated Endocytic Pathway Independent of Eps15. J. Virol. 82: 8112-8123 [Abstract] [Full Text]  
  • Zhao, Z., Ke, F., Huang, Y.-H., Zhao, J.-G., Gui, J.-F., Zhang, Q.-Y. (2008). Identification and characterization of a novel envelope protein in Rana grylio virus. J. Gen. Virol. 89: 1866-1872 [Abstract] [Full Text]  
  • Lee, C.-J., Lin, H.-R., Liao, C.-L., Lin, Y.-L. (2008). Cholesterol Effectively Blocks Entry of Flavivirus. J. Virol. 82: 6470-6480 [Abstract] [Full Text]  
  • Aizaki, H., Morikawa, K., Fukasawa, M., Hara, H., Inoue, Y., Tani, H., Saito, K., Nishijima, M., Hanada, K., Matsuura, Y., Lai, M. M. C., Miyamura, T., Wakita, T., Suzuki, T. (2008). Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection. J. Virol. 82: 5715-5724 [Abstract] [Full Text]  
  • Takahashi, T., Murakami, K., Nagakura, M., Kishita, H., Watanabe, S., Honke, K., Ogura, K., Tai, T., Kawasaki, K., Miyamoto, D., Hidari, K. I. P. J., Guo, C.-T., Suzuki, Y., Suzuki, T. (2008). Sulfatide Is Required for Efficient Replication of Influenza A Virus. J. Virol. 82: 5940-5950 [Abstract] [Full Text]  
  • Swinteck, B. D., Lyles, D. S. (2008). Plasma Membrane Microdomains Containing Vesicular Stomatitis Virus M Protein Are Separate from Microdomains Containing G Protein and Nucleocapsids. J. Virol. 82: 5536-5547 [Abstract] [Full Text]  
  • Medigeshi, G. R., Hirsch, A. J., Streblow, D. N., Nikolich-Zugich, J., Nelson, J. A. (2008). West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of {alpha}v{beta}3 Integrin. J. Virol. 82: 5212-5219 [Abstract] [Full Text]  
  • Biswas, S., Yin, S.-R., Blank, P. S., Zimmerberg, J. (2008). Cholesterol Promotes Hemifusion and Pore Widening in Membrane Fusion Induced by Influenza Hemagglutinin. JGP 131: 503-513 [Abstract] [Full Text]  
  • Catanese, M. T., Graziani, R., von Hahn, T., Moreau, M., Huby, T., Paonessa, G., Santini, C., Luzzago, A., Rice, C. M., Cortese, R., Vitelli, A., Nicosia, A. (2007). High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein. J. Virol. 81: 8063-8071 [Abstract] [Full Text]  
  • Raghu, H., Sharma-Walia, N., Veettil, M. V., Sadagopan, S., Caballero, A., Sivakumar, R., Varga, L., Bottero, V., Chandran, B. (2007). Lipid Rafts of Primary Endothelial Cells Are Essential for Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8-Induced Phosphatidylinositol 3-Kinase and RhoA-GTPases Critical for Microtubule Dynamics and Nuclear Delivery of Viral DNA but Dispensable for Binding and Entry. J. Virol. 81: 7941-7959 [Abstract] [Full Text]  
  • Hambleton, S., Steinberg, S. P., Gershon, M. D., Gershon, A. A. (2007). Cholesterol Dependence of Varicella-Zoster Virion Entry into Target Cells. J. Virol. 81: 7548-7558 [Abstract] [Full Text]  
  • Delmas, O., Breton, M., Sapin, C., Le Bivic, A., Colard, O., Trugnan, G. (2007). Heterogeneity of Raft-Type Membrane Microdomains Associated with VP4, the Rotavirus Spike Protein, in Caco-2 and MA 104 Cells. J. Virol. 81: 1610-1618 [Abstract] [Full Text]  
  • Brown, D. A. (2006). Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals.. Physiology 21: 430-439 [Abstract] [Full Text]  
  • Mannova, P., Fang, R., Wang, H., Deng, B., McIntosh, M. W., Hanash, S. M., Beretta, L. (2006). Modification of Host Lipid Raft Proteome upon Hepatitis C Virus Replication. Mol. Cell. Proteomics 5: 2319-2325 [Abstract] [Full Text]  
  • Loomis, J. S., Courtney, R. J., Wills, J. W. (2006). Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1. J. Virol. 80: 10534-10541 [Abstract] [Full Text]  
  • Xie, X., Xu, L., Yang, F. (2006). Proteomic Analysis of the Major Envelope and Nucleocapsid Proteins of White Spot Syndrome Virus. J. Virol. 80: 10615-10623 [Abstract] [Full Text]  
  • Corcoran, J. A., Salsman, J., de Antueno, R., Touhami, A., Jericho, M. H., Clancy, E. K., Duncan, R. (2006). The p14 Fusion-associated Small Transmembrane (FAST) Protein Effects Membrane Fusion from a Subset of Membrane Microdomains. J. Biol. Chem. 281: 31778-31789 [Abstract] [Full Text]  
  • Xie, X., Yang, F. (2006). White spot syndrome virus VP24 interacts with VP28 and is involved in virus infection. J. Gen. Virol. 87: 1903-1908 [Abstract] [Full Text]  
  • Kolegraff, K., Bostik, P., Ansari, A. A. (2006). Characterization and Role of Lentivirus-Associated Host Proteins. Exp Biol Med 231: 252-263 [Abstract] [Full Text]  
  • Huang, C., Narayanan, K., Ito, N., Peters, C. J., Makino, S. (2006). Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is Released in Membranous Structures from 3a Protein-Expressing Cells and Infected Cells. J. Virol. 80: 210-217 [Abstract] [Full Text]  
  • Vidricaire, G., Tremblay, M. J. (2005). Rab5 and Rab7, but Not ARF6, Govern the Early Events of HIV-1 Infection in Polarized Human Placental Cells. J. Immunol. 175: 6517-6530 [Abstract] [Full Text]  
  • Choi, K. S., Aizaki, H., Lai, M. M. C. (2005). Murine Coronavirus Requires Lipid Rafts for Virus Entry and Cell-Cell Fusion but Not for Virus Release. J. Virol. 79: 9862-9871 [Abstract] [Full Text]  
  • van 't Wout, A. B., Swain, J. V., Schindler, M., Rao, U., Pathmajeyan, M. S., Mullins, J. I., Kirchhoff, F. (2005). Nef Induces Multiple Genes Involved in Cholesterol Synthesis and Uptake in Human Immunodeficiency Virus Type 1-Infected T Cells. J. Virol. 79: 10053-10058 [Abstract] [Full Text]  
  • Bonaparte, M. I., Dimitrov, A. S., Bossart, K. N., Crameri, G., Mungall, B. A., Bishop, K. A., Choudhry, V., Dimitrov, D. S., Wang, L.-F., Eaton, B. T., Broder, C. C. (2005). From The Cover: Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc. Natl. Acad. Sci. USA 102: 10652-10657 [Abstract] [Full Text]  
  • Bartosch, B., Verney, G., Dreux, M., Donot, P., Morice, Y., Penin, F., Pawlotsky, J.-M., Lavillette, D., Cosset, F.-L. (2005). An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies. J. Virol. 79: 8217-8229 [Abstract] [Full Text]  
  • Cantin, R., Methot, S., Tremblay, M. J. (2005). Plunder and Stowaways: Incorporation of Cellular Proteins by Enveloped Viruses. J. Virol. 79: 6577-6587 [Full Text]  
  • Shogomori, H., Hammond, A. T., Ostermeyer-Fay, A. G., Barr, D. J., Feigenson, G. W., London, E., Brown, D. A. (2005). Palmitoylation and Intracellular Domain Interactions Both Contribute to Raft Targeting of Linker for Activation of T Cells. J. Biol. Chem. 280: 18931-18942 [Abstract] [Full Text]  
  • Hammond, A. T., Heberle, F. A., Baumgart, T., Holowka, D., Baird, B., Feigenson, G. W. (2005). Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes. Proc. Natl. Acad. Sci. USA 102: 6320-6325 [Abstract] [Full Text]  
  • Summers, S. A., Nelson, D. H. (2005). A Role for Sphingolipids in Producing the Common Features of Type 2 Diabetes, Metabolic Syndrome X, and Cushing's Syndrome. Diabetes 54: 591-602 [Abstract] [Full Text]  
  • Chung, C.-S., Huang, C.-Y., Chang, W. (2005). Vaccinia Virus Penetration Requires Cholesterol and Results in Specific Viral Envelope Proteins Associated with Lipid Rafts. J. Virol. 79: 1623-1634 [Abstract] [Full Text]  
  • Matto, M., Rice, C. M., Aroeti, B., Glenn, J. S. (2004). Hepatitis C Virus Core Protein Associates with Detergent-Resistant Membranes Distinct from Classical Plasma Membrane Rafts. J. Virol. 78: 12047-12053 [Abstract] [Full Text]  
  • Chu, J. J. H., Ng, M. L. (2004). Infectious Entry of West Nile Virus Occurs through a Clathrin-Mediated Endocytic Pathway. J. Virol. 78: 10543-10555 [Abstract] [Full Text]  
  • York, J., Romanowski, V., Lu, M., Nunberg, J. H. (2004). The Signal Peptide of the Junin Arenavirus Envelope Glycoprotein Is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex. J. Virol. 78: 10783-10792 [Abstract] [Full Text]  
  • Sol-Foulon, N., Esnault, C., Percherancier, Y., Porrot, F., Metais-Cunha, P., Bachelerie, F., Schwartz, O. (2004). The Effects of HIV-1 Nef on CD4 Surface Expression and Viral Infectivity in Lymphoid Cells Are Independent of Rafts. J. Biol. Chem. 279: 31398-31408 [Abstract] [Full Text]  
  • Nagahama, M., Yamaguchi, A., Hagiyama, T., Ohkubo, N., Kobayashi, K., Sakurai, J. (2004). Binding and Internalization of Clostridium perfringens Iota-Toxin in Lipid Rafts. Infect. Immun. 72: 3267-3275 [Abstract] [Full Text]  
  • Hueffer, K., Palermo, L. M., Parrish, C. R. (2004). Parvovirus Infection of Cells by Using Variants of the Feline Transferrin Receptor Altering Clathrin-Mediated Endocytosis, Membrane Domain Localization, and Capsid-Binding Domains. J. Virol. 78: 5601-5611 [Abstract] [Full Text]  
  • Imelli, N., Meier, O., Boucke, K., Hemmi, S., Greber, U. F. (2004). Cholesterol Is Required for Endocytosis and Endosomal Escape of Adenovirus Type 2. J. Virol. 78: 3089-3098 [Abstract] [Full Text]  
  • Nichols, B. (2003). Caveosomes and endocytosis of lipid rafts. J. Cell Sci. 116: 4707-4714 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»