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Microbiology and Molecular Biology Reviews, December 2003, p. 491-502, Vol. 67, No. 4
1092-2172/03/$08.00+0     DOI: 10.1128/MMBR.67.4.491-502.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bioprospecting for Microbial Endophytes and Their Natural Products

Gary Strobel* and Bryn Daisy

Department of Plant Sciences, Montana State University, Bozeman, Montana 59717

Endophytic microorganisms are to be found in virtually every plant on earth. These organisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic. Because of what appears to be their contribution to the host plant, the endophytes may produce a plethora of substances of potential use to modern medicine, agriculture, and industry. Novel antibiotics, antimycotics, immunosuppressants, and anticancer compounds are only a few examples of what has been found after the isolation, culture, purification, and characterization of some choice endophytes in the recent past. The potential prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great.

* Corresponding author. Mailing address: Department of Plant Sciences, Montana State University, Bozeman, MT 59717. Phone: (406) 994-5148. Fax: (406) 994-7600. E-mail: uplgs{at}montana.edu.

Microbiology and Molecular Biology Reviews, December 2003, p. 491-502, Vol. 67, No. 4
1092-2172/03/$08.00+0     DOI: 10.1128/MMBR.67.4.491-502.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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