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Microbiology and Molecular Biology Reviews, March 2004, p. 154-171, Vol. 68, No. 1
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.1.154-171.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Iron Transport Systems in Neisseria meningitidis{dagger}

Donna Perkins-Balding,* Melanie Ratliff-Griffin, and Igor Stojiljkovic

Rollins Research Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322

Acquisition of iron and iron complexes has long been recognized as a major determinant in the pathogenesis of Neisseria meningitidis. In this review, high-affinity iron uptake systems, which allow meningococci to utilize the human host proteins transferrin, lactoferrin, hemoglobin, and haptoglobin-hemoglobin as sources of essential iron, are described. Classic features of bacterial iron transport systems, such as regulation by the iron-responsive repressor Fur and TonB-dependent transport activity, are discussed, as well as more specific features of meningococcal iron transport. Our current understanding of how N. meningitidis acquires iron from the human host and the vaccine potentials of various components of these iron transport systems are also reviewed.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory School of Medicine, Rollins Research Center, 1510 Clifton Rd., Rm. 3152, Atlanta, GA 30322. Phone: (404) 727-5968. Fax: (404) 727-3659. E-mail: dbaldin{at}emory.edu.

{dagger} D.P.-B. and M.R.-G. dedicate this paper to the memory of Igor Stojiljkovic (1959-2003).

Microbiology and Molecular Biology Reviews, March 2004, p. 154-171, Vol. 68, No. 1
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.1.154-171.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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