This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roux, P. P.
Right arrow Articles by Blenis, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roux, P. P.
Right arrow Articles by Blenis, J.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, June 2004, p. 320-344, Vol. 68, No. 2
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.2.320-344.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

Philippe P. Roux* and John Blenis

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115

Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying extracellular stimulations to intracellular responses. The MAPKs coordinately regulate cell proliferation, differentiation, motility, and survival, which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases). The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs. There are currently 11 vertebrate MKs in five subfamilies based on primary sequence homology: the ribosomal S6 kinases, the mitogen- and stress-activated kinases, the MAPK-interacting kinases, MAPK-activated protein kinases 2 and 3, and MK5. In the last 5 years, several MK substrates have been identified, which has helped tremendously to identify the biological role of the members of this family. Together with data from the study of MK-knockout mice, the identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses. In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries.

* Corresponding author. Mailing address: Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115. Phone: (617) 432-1281. Fax: (617) 432-1144. E-mail: proux{at}hms.harvard.edu.

Microbiology and Molecular Biology Reviews, June 2004, p. 320-344, Vol. 68, No. 2
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.2.320-344.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Piette, C., Deprez, M., Roger, T., Noel, A., Foidart, J.-M., Munaut, C. (2009). The Dexamethasone-induced Inhibition of Proliferation, Migration, and Invasion in Glioma Cell Lines Is Antagonized by Macrophage Migration Inhibitory Factor (MIF) and Can Be Enhanced by Specific MIF Inhibitors. J. Biol. Chem. 284: 32483-32492 [Abstract] [Full Text]  
  • Clayton, C. C., Xu, M., Chavkin, C. (2009). Tyrosine Phosphorylation of Kir3 following {kappa}-Opioid Receptor Activation of p38 MAPK Causes Heterologous Desensitization. J. Biol. Chem. 284: 31872-31881 [Abstract] [Full Text]  
  • Guy, G R, Jackson, R A, Yusoff, P, Chow, S Y (2009). Sprouty proteins: modified modulators, matchmakers or missing links?. J Endocrinol 203: 191-202 [Abstract] [Full Text]  
  • O'Mahony, F., Alzamora, R., Chung, H.-L., Thomas, W., Harvey, B. J. (2009). Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle. Mol. Endocrinol. 23: 1885-1899 [Abstract] [Full Text]  
  • Sixt, M.-L., Messlinger, K., Fischer, M. J. M. (2009). Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus. Brain 132: 3134-3141 [Abstract] [Full Text]  
  • Chang, Y.-M., Shih, Y.-T., Chen, Y.-S., Liu, C.-L., Fang, W.-K., Tsai, C.-H., Tsai, F.-J., Kuo, W.-W., Lai, T.-Y., Huang, C.-Y. (2009). Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38. Evid Based Complement Alternat Med 0: nep131v1-nep131 [Abstract] [Full Text]  
  • Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., Vigneri, R. (2009). Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease. Endocr. Rev. 30: 586-623 [Abstract] [Full Text]  
  • Rodriguez-Garcia, M. E., Quiroga, A. G., Castro, J., Ortiz, A., Aller, P., Mata, F. (2009). Inhibition of p38-MAPK Potentiates Cisplatin-Induced Apoptosis via GSH Depletion and Increases Intracellular Drug Accumulation in Growth-Arrested Kidney Tubular Epithelial Cells. Toxicol Sci 111: 413-423 [Abstract] [Full Text]  
  • Thandavarayan, R. A., Watanabe, K., Ma, M., Gurusamy, N., Veeraveedu, P. T., Konishi, T., Zhang, S., Muslin, A. J., Kodama, M., Aizawa, Y. (2009). Dominant-negative p38{alpha} mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am. J. Physiol. Heart Circ. Physiol. 297: H911-H919 [Abstract] [Full Text]  
  • Ansari, H. R., Teng, B., Nadeem, A., Roush, K. P., Martin, K. H., Schnermann, J., Mustafa, S. J. (2009). A1 adenosine receptor-mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 297: H1032-H1039 [Abstract] [Full Text]  
  • Malik, A. I., Storey, K. B. (2009). Activation of extracellular signal-regulated kinases during dehydration in the African clawed frog, Xenopus laevis. J. Exp. Biol. 212: 2595-2603 [Abstract] [Full Text]  
  • Periyasamy-Thandavan, S., Jiang, M., Schoenlein, P., Dong, Z. (2009). Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am. J. Physiol. Renal Physiol. 297: F244-F256 [Abstract] [Full Text]  
  • Bajbouj, K., Poehlmann, A., Kuester, D., Drewes, T., Haase, K., Hartig, R., Teller, A., Kliche, S., Walluscheck, D., Ivanovska, J., Chakilam, S., Ulitzsch, A., Bommhardt, U., Leverkus, M., Roessner, A., Schneider-Stock, R. (2009). Identification of Phosphorylated p38 as a Novel DAPK-Interacting Partner during TNF{alpha}-Induced Apoptosis in Colorectal Tumor Cells. Am. J. Pathol. 175: 557-570 [Abstract] [Full Text]  
  • Aberg, E., Torgersen, K. M., Johansen, B., Keyse, S. M., Perander, M., Seternes, O.-M. (2009). Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif. J. Biol. Chem. 284: 19392-19401 [Abstract] [Full Text]  
  • Larrea, M. D., Hong, F., Wander, S. A., da Silva, T. G., Helfman, D., Lannigan, D., Smith, J. A., Slingerland, J. M. (2009). RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc. Natl. Acad. Sci. USA 106: 9268-9273 [Abstract] [Full Text]  
  • Mittelstadt, P. R., Yamaguchi, H., Appella, E., Ashwell, J. D. (2009). T Cell Receptor-mediated Activation of p38{alpha} by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity. J. Biol. Chem. 284: 15469-15474 [Abstract] [Full Text]  
  • Sagou, K., Imai, T., Sagara, H., Uema, M., Kawaguchi, Y. (2009). Regulation of the Catalytic Activity of Herpes Simplex Virus 1 Protein Kinase Us3 by Autophosphorylation and Its Role in Pathogenesis. J. Virol. 83: 5773-5783 [Abstract] [Full Text]  
  • Tamizhselvi, R., Sun, J., Koh, Y.-H., Bhatia, M. (2009). Effect of Hydrogen Sulfide on the Phosphatidylinositol 3-Kinase-Protein Kinase B Pathway and on Caerulein-Induced Cytokine Production in Isolated Mouse Pancreatic Acinar Cells. J. Pharmacol. Exp. Ther. 329: 1166-1177 [Abstract] [Full Text]  
  • Kuang, E., Wu, F., Zhu, F. (2009). Mechanism of Sustained Activation of Ribosomal S6 Kinase (RSK) and ERK by Kaposi Sarcoma-associated Herpesvirus ORF45: MULTIPROTEIN COMPLEXES RETAIN ACTIVE PHOSPHORYLATED ERK AND RSK AND PROTECT THEM FROM DEPHOSPHORYLATION. J. Biol. Chem. 284: 13958-13968 [Abstract] [Full Text]  
  • Cho, Y.-Y., Yao, K., Pugliese, A., Malakhova, M. L., Bode, A. M., Dong, Z. (2009). A Regulatory Mechanism for RSK2 NH2-Terminal Kinase Activity. Cancer Res. 69: 4398-4406 [Abstract] [Full Text]  
  • Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S., Paludan, S. R. (2009). RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1. J. Biol. Chem. 284: 10774-10782 [Abstract] [Full Text]  
  • Kakugawa, S., Shimojima, M., Goto, H., Horimoto, T., Oshimori, N., Neumann, G., Yamamoto, T., Kawaoka, Y. (2009). Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection. J. Virol. 83: 2510-2517 [Abstract] [Full Text]  
  • Gharib, M., Marcantonio, M., Lehmann, S. G., Courcelles, M., Meloche, S., Verreault, A., Thibault, P. (2009). Artifactual Sulfation of Silver-stained Proteins: Implications for the Assignment of Phosphorylation and Sulfation Sites. Mol. Cell. Proteomics 8: 506-518 [Abstract] [Full Text]  
  • Gillis, P. A., Okagaki, L. H., Rice, S. A. (2009). Herpes Simplex Virus Type 1 ICP27 Induces p38 Mitogen-Activated Protein Kinase Signaling and Apoptosis in HeLa Cells. J. Virol. 83: 1767-1777 [Abstract] [Full Text]  
  • Sanchez-Nino, M. D., Sanz, A. B., Ihalmo, P., Lassila, M., Holthofer, H., Mezzano, S., Aros, C., Groop, P.-H., Saleem, M. A., Mathieson, P. W., Langham, R., Kretzler, M., Nair, V., Lemley, K. V., Nelson, R. G., Mervaala, E., Mattinzoli, D., Rastaldi, M. P., Ruiz-Ortega, M., Martin-Ventura, J. L., Egido, J., Ortiz, A. (2009). The MIF Receptor CD74 in Diabetic Podocyte Injury. J. Am. Soc. Nephrol. 20: 353-362 [Abstract] [Full Text]  
  • Garcia, P., Tajadura, V., Sanchez, Y. (2009). The Rho1p Exchange Factor Rgf1p Signals Upstream from the Pmk1 Mitogen-activated Protein Kinase Pathway in Fission Yeast. Mol. Biol. Cell 20: 721-731 [Abstract] [Full Text]  
  • Chiloeches, A., Sanchez-Pacheco, A., Gil-Araujo, B., Aranda, A., Lasa, M. (2008). Thyroid Hormone-Mediated Activation of the ERK/Dual Specificity Phosphatase 1 Pathway Augments the Apoptosis of GH4C1 Cells by Down-Regulating Nuclear Factor-{kappa}B Activity. Mol. Endocrinol. 22: 2466-2480 [Abstract] [Full Text]  
  • Kim, M.-J., Choi, S.-Y., Park, I.-C., Hwang, S.-G., Kim, C., Choi, Y.-H., Kim, H., Lee, K.-H., Lee, S.-J. (2008). Opposing Roles of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in the Cellular Response to Ionizing Radiation in Human Cervical Cancer Cells. Mol Cancer Res 6: 1718-1731 [Abstract] [Full Text]  
  • Zhang, Y.-Y., Mei, Z.-Q., Wu, J.-W., Wang, Z.-X. (2008). Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38{alpha} in Different Phosphorylation States. J. Biol. Chem. 283: 26591-26601 [Abstract] [Full Text]  
  • Naidu, S., Wijayanti, N., Santoso, S., Kietzmann, T., Immenschuh, S. (2008). An Atypical NF-{kappa}B-Regulated Pathway Mediates Phorbol Ester-Dependent Heme Oxygenase-1 Gene Activation in Monocytes. J. Immunol. 181: 4113-4123 [Abstract] [Full Text]  
  • Murk, W., Atabekoglu, C. S., Cakmak, H., Heper, A., Ensari, A., Kayisli, U. A., Arici, A. (2008). Extracellularly Signal-Regulated Kinase Activity in the Human Endometrium: Possible Roles in the Pathogenesis of Endometriosis. J. Clin. Endocrinol. Metab. 93: 3532-3540 [Abstract] [Full Text]  
  • Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Leyen, T., van het Hof, B., Couraud, P.-O., Vivien, D., Dijkstra, C. D., de Vries, H. E. (2008). Tissue-Type Plasminogen Activator Is a Regulator of Monocyte Diapedesis through the Brain Endothelial Barrier. J. Immunol. 181: 3567-3574 [Abstract] [Full Text]  
  • Sun, J., Ramnath, R. D., Tamizhselvi, R., Bhatia, M. (2008). Neurokinin A engages neurokinin-1 receptor to induce NF-{kappa}B-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. Am. J. Physiol. Cell Physiol. 295: C679-C691 [Abstract] [Full Text]  
  • Hussain, T., Nasreen, N., Lai, Y., Bellew, B. F., Antony, V. B., Mohammed, K. A. (2008). Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of {beta}-defensin-2 by staphylococcal peptidoglycan. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L461-L470 [Abstract] [Full Text]  
  • Ren, J.-G., Li, Z., Sacks, D. B. (2008). IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling. J. Biol. Chem. 283: 22972-22982 [Abstract] [Full Text]  
  • Proctor, B. M., Jin, X., Lupu, T. S., Muglia, L. J., Semenkovich, C. F., Muslin, A. J. (2008). Requirement for p38 Mitogen-Activated Protein Kinase Activity in Neointima Formation After Vascular Injury. Circulation 118: 658-666 [Abstract] [Full Text]  
  • Zhang, Y., Bai, X.-T., Zhu, K.-Y., Jin, Y., Deng, M., Le, H.-Y., Fu, Y.-F., Chen, Y., Zhu, J., Look, A. T., Kanki, J., Chen, Z., Chen, S.-J., Liu, T. X. (2008). In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury. J. Immunol. 181: 2155-2164 [Abstract] [Full Text]  
  • Kuwano, Y., Kim, H. H., Abdelmohsen, K., Pullmann, R. Jr., Martindale, J. L., Yang, X., Gorospe, M. (2008). MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90. Mol. Cell. Biol. 28: 4562-4575 [Abstract] [Full Text]  
  • Kato, A., Tanaka, M., Yamamoto, M., Asai, R., Sata, T., Nishiyama, Y., Kawaguchi, Y. (2008). Identification of a Physiological Phosphorylation Site of the Herpes Simplex Virus 1-Encoded Protein Kinase Us3 Which Regulates Its Optimal Catalytic Activity In Vitro and Influences Its Function in Infected Cells. J. Virol. 82: 6172-6189 [Abstract] [Full Text]  
  • Sorensen, V., Zhen, Y., Zakrzewska, M., Haugsten, E. M., Walchli, S., Nilsen, T., Olsnes, S., Wiedlocha, A. (2008). Phosphorylation of Fibroblast Growth Factor (FGF) Receptor 1 at Ser777 by p38 Mitogen-Activated Protein Kinase Regulates Translocation of Exogenous FGF1 to the Cytosol and Nucleus. Mol. Cell. Biol. 28: 4129-4141 [Abstract] [Full Text]  
  • Mokhtari, D., Myers, J. W., Welsh, N. (2008). The MAPK Kinase Kinase-1 Is Essential for Stress-Induced Pancreatic Islet Cell Death. Endocrinology 149: 3046-3053 [Abstract] [Full Text]  
  • Rodriguez, M., Kim, B., Lee, N.-S., Veeranki, S., Kim, L. (2008). MPL1, a Novel Phosphatase with Leucine-Rich Repeats, Is Essential for Proper ERK2 Phosphorylation and Cell Motility. Eukaryot Cell 7: 958-966 [Abstract] [Full Text]  
  • Sun, J., Ramnath, R. D., Zhi, L., Tamizhselvi, R., Bhatia, M. (2008). Substance P enhances NF-{kappa}B transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. Am. J. Physiol. Cell Physiol. 294: C1586-C1596 [Abstract] [Full Text]  
  • Lerner-Marmarosh, N., Miralem, T., Gibbs, P. E. M., Maines, M. D. (2008). Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc. Natl. Acad. Sci. USA 105: 6870-6875 [Abstract] [Full Text]  
  • Sethu, S., Mendez-Corao, G., Melendez, A. J. (2008). Phospholipase D1 Plays a Key Role in TNF-{alpha} Signaling. J. Immunol. 180: 6027-6034 [Abstract] [Full Text]  
  • Voong, L. N., Slater, A. R., Kratovac, S., Cressman, D. E. (2008). Mitogen-activated Protein Kinase ERK1/2 Regulates the Class II Transactivator. J. Biol. Chem. 283: 9031-9039 [Abstract] [Full Text]  
  • Morrison, P. J., Hara, D., Ding, Z., Ivy, J. L. (2008). Adding protein to a carbohydrate supplement provided after endurance exercise enhances 4E-BP1 and RPS6 signaling in skeletal muscle. J. Appl. Physiol. 104: 1029-1036 [Abstract] [Full Text]  
  • Junttila, M. R., Li, S.-P., Westermarck, J. (2008). Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22: 954-965 [Abstract] [Full Text]  
  • Vyshemirsky, V., Girolami, M. A. (2008). Bayesian ranking of biochemical system models. Bioinformatics 24: 833-839 [Abstract] [Full Text]  
  • Stanic, D., Paratcha, G., Ledda, F., Herzog, H., Kopin, A. S., Hokfelt, T. (2008). Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Proc. Natl. Acad. Sci. USA 105: 3610-3615 [Abstract] [Full Text]  
  • Wasylyk, C., Zheng, H., Castell, C., Debussche, L., Multon, M.-C., Wasylyk, B. (2008). Inhibition of the Ras-Net (Elk-3) Pathway by a Novel Pyrazole that Affects Microtubules. Cancer Res. 68: 1275-1283 [Abstract] [Full Text]  
  • Kuang, E., Tang, Q., Maul, G. G., Zhu, F. (2008). Activation of p90 Ribosomal S6 Kinase by ORF45 of Kaposi's Sarcoma-Associated Herpesvirus and Its Role in Viral Lytic Replication. J. Virol. 82: 1838-1850 [Abstract] [Full Text]  
  • Martin, M. C., Allan, L. A., Mancini, E. J., Clarke, P. R. (2008). The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125. J. Biol. Chem. 283: 3854-3865 [Abstract] [Full Text]  
  • Helikar, T., Konvalina, J., Heidel, J., Rogers, J. A. (2008). Emergent decision-making in biological signal transduction networks. Proc. Natl. Acad. Sci. USA 105: 1913-1918 [Abstract] [Full Text]  
  • Dai, J.-Q., Zhu, X.-J., Liu, F.-Q., Xiang, J.-H., Nagasawa, H., Yang, W.-J. (2008). Involvement of p90 Ribosomal S6 Kinase in Termination of Cell Cycle Arrest during Development of Artemia-encysted Embryos. J. Biol. Chem. 283: 1705-1712 [Abstract] [Full Text]  
  • Eckstein, N., Servan, K., Girard, L., Cai, D., von Jonquieres, G., Jaehde, U., Kassack, M. U., Gazdar, A. F., Minna, J. D., Royer, H.-D. (2008). Epidermal Growth Factor Receptor Pathway Analysis Identifies Amphiregulin as a Key Factor for Cisplatin Resistance of Human Breast Cancer Cells. J. Biol. Chem. 283: 739-750 [Abstract] [Full Text]  
  • Chen, D., Wilkinson, C. R.M., Watt, S., Penkett, C. J., Toone, W. M., Jones, N., Bahler, J. (2008). Multiple Pathways Differentially Regulate Global Oxidative Stress Responses in Fission Yeast. Mol. Biol. Cell 19: 308-317 [Abstract] [Full Text]  
  • Gerits, N., Mikalsen, T., Kostenko, S., Shiryaev, A., Johannessen, M., Moens, U. (2007). Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5. J. Biol. Chem. 282: 37232-37243 [Abstract] [Full Text]  
  • Zenkel, M., Kruse, F. E., Naumann, G. O. H., Schlotzer-Schrehardt, U. (2007). Impaired Cytoprotective Mechanisms in Eyes with Pseudoexfoliation Syndrome/Glaucoma. IOVS 48: 5558-5566 [Abstract] [Full Text]  
  • Coss, D., Hand, C. M., Yaphockun, K. K. J., Ely, H. A., Mellon, P. L. (2007). p38 Mitogen-Activated Protein Kinase Is Critical for Synergistic Induction of the FSH{beta} Gene by Gonadotropin-Releasing Hormone and Activin through Augmentation of c-Fos Induction and Smad Phosphorylation. Mol. Endocrinol. 21: 3071-3086 [Abstract] [Full Text]  
  • Rayalam, S., Della-Fera, M. A., Yang, J.-Y., Park, H. J., Ambati, S., Baile, C. A. (2007). Resveratrol Potentiates Genistein's Antiadipogenic and Proapoptotic Effects in 3T3-L1 Adipocytes. J. Nutr. 137: 2668-2673 [Abstract] [Full Text]  
  • Patzak, A., Lai, E. Y., Fahling, M., Sendeski, M., Martinka, P., Persson, P. B., Persson, A. E. G. (2007). Adenosine enhances long term the contractile response to angiotensin II in afferent arterioles. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293: R2232-R2242 [Abstract] [Full Text]  
  • Madrid, M., Nunez, A., Soto, T., Vicente-Soler, J., Gacto, M., Cansado, J. (2007). Stress-activated Protein Kinase-mediated Down-Regulation of the Cell Integrity Pathway Mitogen-activated Protein Kinase Pmk1p by Protein Phosphatases. Mol. Biol. Cell 18: 4405-4419 [Abstract] [Full Text]  
  • Amazit, L., Pasini, L., Szafran, A. T., Berno, V., Wu, R.-C., Mielke, M., Jones, E. D., Mancini, M. G., Hinojos, C. A., O'Malley, B. W., Mancini, M. A. (2007). Regulation of SRC-3 Intercompartmental Dynamics by Estrogen Receptor and Phosphorylation. Mol. Cell. Biol. 27: 6913-6932 [Abstract] [Full Text]  
  • Kim, S.-W., Hong, J. S., Ryu, S.-H., Chung, W.-C., Yoon, J.-H., Koo, J. S. (2007). Regulation of Mucin Gene Expression by CREB via a Nonclassical Retinoic Acid Signaling Pathway. Mol. Cell. Biol. 27: 6933-6947 [Abstract] [Full Text]  
  • James, B. P., Bunch, T. A., Krishnamoorthy, S., Perkins, L. A., Brower, D. L. (2007). Nuclear Localization of the ERK MAP Kinase Mediated by Drosophila {alpha}PS2betaPS Integrin and Importin-7. Mol. Biol. Cell 18: 4190-4199 [Abstract] [Full Text]  
  • Wang, Y. (2007). Mitogen-Activated Protein Kinases in Heart Development and Diseases. Circulation 116: 1413-1423 [Abstract] [Full Text]  
  • Chen, D., Reierstad, S., Lin, Z., Lu, M., Brooks, C., Li, N., Innes, J., Bulun, S. E. (2007). Prostaglandin E2 Induces Breast Cancer Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts. Cancer Res. 67: 8914-8922 [Abstract] [Full Text]  
  • McKay, M. M., Morrison, D. K. (2007). Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1. J. Biol. Chem. 282: 26225-26234 [Abstract] [Full Text]  
  • Cho, Y.-Y., Yao, K., Kim, H.-G., Kang, B. S., Zheng, D., Bode, A. M., Dong, Z. (2007). Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter Induced Cell Transformation. Cancer Res. 67: 8104-8112 [Abstract] [Full Text]  
  • Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J., Meloche, S., Smith, A. (2007). FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134: 2895-2902 [Abstract] [Full Text]  
  • Tesz, G. J., Guilherme, A., Guntur, K. V. P., Hubbard, A. C., Tang, X., Chawla, A., Czech, M. P. (2007). Tumor Necrosis Factor {alpha} (TNF{alpha}) Stimulates Map4k4 Expression through TNF{alpha} Receptor 1 Signaling to c-Jun and Activating Transcription Factor 2. J. Biol. Chem. 282: 19302-19312 [Abstract] [Full Text]  
  • Kelley, M. J., Rose, A., Song, K., Lystrup, B., Samples, J. W., Acott, T. S. (2007). p38 MAP Kinase Pathway and Stromelysin Regulation in Trabecular Meshwork Cells. IOVS 48: 3126-3137 [Abstract] [Full Text]  
  • Kramer, H. F., Goodyear, L. J. (2007). Exercise, MAPK, and NF-{kappa}B signaling in skeletal muscle. J. Appl. Physiol. 103: 388-395 [Abstract] [Full Text]  
  • Ren, J.-G., Li, Z., Sacks, D. B. (2007). IQGAP1 modulates activation of B-Raf. Proc. Natl. Acad. Sci. USA 104: 10465-10469 [Abstract] [Full Text]  
  • Prickett, T. D., Brautigan, D. L. (2007). Cytokine Activation of p38 Mitogen-Activated Protein Kinase and Apoptosis Is Opposed by alpha-4 Targeting of Protein Phosphatase 2A for Site-Specific Dephosphorylation of MEK3. Mol. Cell. Biol. 27: 4217-4227 [Abstract] [Full Text]  
  • Nonn, L., Duong, D., Peehl, D. M. (2007). Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 28: 1188-1196 [Abstract] [Full Text]  
  • Mendoza, M. C., Booth, E. O., Shaulsky, G., Firtel, R. A. (2007). MEK1 and Protein Phosphatase 4 Coordinate Dictyostelium Development and Chemotaxis. Mol. Cell. Biol. 27: 3817-3827 [Abstract] [Full Text]  
  • Roux, P. P., Shahbazian, D., Vu, H., Holz, M. K., Cohen, M. S., Taunton, J., Sonenberg, N., Blenis, J. (2007). RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation. J. Biol. Chem. 282: 14056-14064 [Abstract] [Full Text]  
  • Hornsby, P. J. (2007). Senescence As an Anticancer Mechanism. JCO 25: 1852-1857 [Abstract] [Full Text]  
  • Xue, M., Campbell, D., Jackson, C. J. (2007). Protein C Is an Autocrine Growth Factor for Human Skin Keratinocytes. J. Biol. Chem. 282: 13610-13616 [Abstract] [Full Text]  
  • Kobayashi, T., Puro, D. G. (2007). Loss of Insulin-Mediated Vasoprotection: Early Effect of Diabetes on Pericyte-Containing Microvessels of the Retina. IOVS 48: 2350-2355 [Abstract] [Full Text]  
  • Russell, D. L., Robker, R. L. (2007). Molecular mechanisms of ovulation: co-ordination through the cumulus complex. Hum Reprod Update 13: 289-312 [Abstract] [Full Text]  
  • Zhi, L., Ang, A. D., Zhang, H., Moore, P. K., Bhatia, M. (2007). Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-{kappa}B pathway. J. Leukoc. Biol. 81: 1322-1332 [Abstract] [Full Text]  
  • van Wijk, B., Moorman, A. F.M., van den Hoff, M. J.B. (2007). Role of bone morphogenetic proteins in cardiac differentiation. Cardiovasc Res 74: 244-255 [Abstract] [Full Text]  
  • Suzuki, K., Wilkes, M. C., Garamszegi, N., Edens, M., Leof, E. B. (2007). Transforming Growth Factor {beta} Signaling via Ras in Mesenchymal Cells Requires p21-Activated Kinase 2 for Extracellular Signal-Regulated Kinase-Dependent Transcriptional Responses. Cancer Res. 67: 3673-3682 [Abstract] [Full Text]  
  • Zhang, L., Yang, S.-H., Sharrocks, A. D. (2007). Rev7/MAD2B Links c-Jun N-Terminal Protein Kinase Pathway Signaling to Activation of the Transcription Factor Elk-1. Mol. Cell. Biol. 27: 2861-2869 [Abstract] [Full Text]  
  • Gupta, V., Awasthi, N., Wagner, B. J. (2007). Specific Activation of the Glucocorticoid Receptor and Modulation of Signal Transduction Pathways in Human Lens Epithelial Cells. IOVS 48: 1724-1734 [Abstract] [Full Text]  
  • Wang, X., Goh, C. H., Li, B. (2007). p38 Mitogen-Activated Protein Kinase Regulates Osteoblast Differentiation through Osterix. Endocrinology 148: 1629-1637 [Abstract] [Full Text]  
  • Ebner, H. L., Blatzer, M., Nawaz, M., Krumschnabel, G. (2007). Activation and nuclear translocation of ERK in response to ligand-dependent and -independent stimuli in liver and gill cells from rainbow trout. J. Exp. Biol. 210: 1036-1045 [Abstract] [Full Text]  
  • Ryan, K E, Casey, S M, Canty, M J, Crowe, M A, Martin, F, Evans, A C O (2007). Akt and Erk signal transduction pathways are early markers of differentiation in dominant and subordinate ovarian follicles in cattle. Reproduction 133: 617-626 [Abstract] [Full Text]  
  • Patel, O., Dumesny, C., Shulkes, A., Baldwin, G. S. (2007). C-Terminal Fragments of the Gastrin-Releasing Peptide Precursor Stimulate Cell Proliferation via a Novel Receptor. Endocrinology 148: 1330-1339 [Abstract] [Full Text]  
  • Ehlting, C., Lai, W. S., Schaper, F., Brenndorfer, E. D., Matthes, R.-J., Heinrich, P. C., Ludwig, S., Blackshear, P. J., Gaestel, M., Haussinger, D., Bode, J. G. (2007). Regulation of Suppressor of Cytokine Signaling 3 (SOCS3) mRNA Stability by TNF-{alpha} Involves Activation of the MKK6/p38MAPK/MK2 Cascade. J. Immunol. 178: 2813-2826 [Abstract] [Full Text]  
  • Zhang, G., Kernan, K. A., Collins, S. J., Cai, X., Lopez-Guisa, J. M., Degen, J. L., Shvil, Y., Eddy, A. A. (2007). Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals. J. Am. Soc. Nephrol. 18: 846-859 [Abstract] [Full Text]  
  • Liang, F., Liang, J., Wang, W.-Q., Sun, J.-P., Udho, E., Zhang, Z.-Y. (2007). PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation. J. Biol. Chem. 282: 5413-5419 [Abstract] [Full Text]  
  • Ronkina, N., Kotlyarov, A., Dittrich-Breiholz, O., Kracht, M., Hitti, E., Milarski, K., Askew, R., Marusic, S., Lin, L.-L., Gaestel, M., Telliez, J.-B. (2007). The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK. Mol. Cell. Biol. 27: 170-181 [Abstract] [Full Text]  
  • Liu, B., Wu, J.-f., Zhan, Y.-y., Chen, H.-z., Zhang, X.-y., Wu, Q. (2007). Regulation of the Orphan Receptor TR3 Nuclear Functions by c-Jun N Terminal Kinase Phosphorylation. Endocrinology 148: 34-44 [Abstract] [Full Text]  
  • Wang, Y., Zeigler, M. M., Lam, G. K., Hunter, M. G., Eubank, T. D., Khramtsov, V. V., Tridandapani, S., Sen, C. K., Marsh, C. B. (2007). The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival. Am. J. Respir. Cell Mol. Bio. 36: 68-77 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»