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Microbiology and Molecular Biology Reviews, September 2004, p. 453-473, Vol. 68, No. 3
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.3.453-473.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CO-Sensing Mechanisms

Gary P. Roberts,* Hwan Youn, and Robert L. Kerby

Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin

Carbon monoxide (CO) has long been known to have dramatic physiological effects on organisms ranging from bacteria to humans, but recently there have a number of suggestions that organisms might have specific sensors for CO. This article reviews the current evidence for a variety of proteins with demonstrated or potential CO-sensing ability. Particular emphasis is placed on the molecular description of CooA, a heme-containing CO sensor from Rhodospirillum rubrum, since its biological role as a CO sensor is clear and we have substantial insight into the basis of its sensing ability.

* Corresponding author. Mailing address: Department of Bacteriology, 420 Henry Mall, University of Wisconsin—Madison, Madison, WI 53706. Phone: (608) 262-3567. Fax: (608) 262-9865. E-mail: groberts{at}bact.wisc.edu.

Microbiology and Molecular Biology Reviews, September 2004, p. 453-473, Vol. 68, No. 3
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.3.453-473.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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