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Little Lambda, Who Made Thee?

Institute of Cancer Research, Columbia University, New York, New York,¹ Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, Maryland²

The study of the bacteriophage has been critical to the discipline of molecular biology. It was the source of key discoveries in the mechanisms of, among other processes, gene regulation, recombination, and transcription initiation and termination. We trace here the events surrounding these findings and draw on the recollections of the participants. We show how a particular atmosphere of interactions among creative scientists yielded spectacular insights into how living things work.

With apologies to William Blake.