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Microbiology and Molecular Biology Reviews, June 2006, p. 317-343, Vol. 70, No. 2
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00038-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cell Wall Assembly in Saccharomyces cerevisiae

Guillaume Lesage and Howard Bussey*

Department of Biology, McGill University, Montreal, Quebec, Canada

An extracellular matrix composed of a layered meshwork of ß-glucans, chitin, and mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle determines cellular morphology and plays a critical role in maintaining cell integrity during cell growth and division, under stress conditions, upon cell fusion in mating, and in the durable ascospore cell wall. Here we assess recent progress in understanding the molecular biology and biochemistry of cell wall synthesis and its remodeling in S. cerevisiae. We then review the regulatory dynamics of cell wall assembly, an area where functional genomics offers new insights into the integration of cell wall growth and morphogenesis with a polarized secretory system that is under cell cycle and cell type program controls.

* Corresponding author. Mailing address: Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montreal, PQ H3A 1B1, Canada. Phone: (514) 398-6439. Fax: (514) 398-8051. E-mail: howard.bussey{at}mcgill.ca.

Microbiology and Molecular Biology Reviews, June 2006, p. 317-343, Vol. 70, No. 2
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00038-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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