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Microbiology and Molecular Biology Reviews, September 2006, p. 704-728, Vol. 70, No. 3
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00004-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genetics of Streptomyces rimosus, the Oxytetracycline Producer

Hrvoje Petkovic,1 John Cullum,2 Daslav Hranueli,3 Iain S. Hunter,4 Natasa Peric-Concha,5 Jasenka Pigac,6 Arinthip Thamchaipenet,7 Dusica Vujaklija,6 and Paul F. Long5*

Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia,1 Department of Genetics, University of Kaiserslautern, Kaiserslautern, Germany,2 Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia,3 Royal College, University of Strathclyde, Glasgow, Scotland,4 School of Pharmacy, University of London, London, England,5 Department of Molecular Biology, Ruðer Boskovic Institute, Zagreb, Croatia,6 Faculty of Science, Kasetsart University, Bangkok, Thailand7

From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo and in vitro genetic manipulations in S. rimosus have been developed since the 1950s and applied to study the genetic instability of S. rimosus strains and for the molecular cloning and characterization of genes involved in oxytetracycline biosynthesis. Recent advances in the methodology of genome sequencing bring the realistic prospect of obtaining the genome sequence of S. rimosus in the near term.

* Corresponding author. Mailing address: The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom. Phone: 44-20-77535868. Fax: 44-20-77535868. E-mail: paul.long{at}ams1.ulsop.ac.uk.

Microbiology and Molecular Biology Reviews, September 2006, p. 704-728, Vol. 70, No. 3
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00004-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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