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Microbiology and Molecular Biology Reviews, December 2006, p. 876-887, Vol. 70, No. 4
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00029-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

DNA Replication in the Archaea

Elizabeth R. Barry and Stephen D. Bell*

MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom

The archaeal DNA replication machinery bears striking similarity to that of eukaryotes and is clearly distinct from the bacterial apparatus. In recent years, considerable advances have been made in understanding the biochemistry of the archaeal replication proteins. Furthermore, a number of structures have now been obtained for individual components and higher-order assemblies of archaeal replication factors, yielding important insights into the mechanisms of DNA replication in both archaea and eukaryotes.


* Corresponding author. Mailing address: MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom. Phone: 44 (0)1223 763311. Fax: 44 (0)1223 763296. E-mail: sb419{at}hutchison-mrc.cam.ac.uk.


Microbiology and Molecular Biology Reviews, December 2006, p. 876-887, Vol. 70, No. 4
1092-2172/06/$08.00+0     doi:10.1128/MMBR.00029-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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