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Microbiology and Molecular Biology Reviews, September 2008, p. 495-544, Vol. 72, No. 3
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00032-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Candida albicans Cell Wall Proteins

W. LaJean Chaffin*

Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, Texas 79430

Summary: The Candida albicans cell wall maintains the structural integrity of the organism in addtion to providing a physical contact interface with the environment. The major components of the cell wall are fibrillar polysaccharides and proteins. The proteins of the cell wall are the focus of this review. Three classes of proteins are present in the candidal cell wall. One group of proteins attach to the cell wall via a glycophosphatidylinositol remnant or by an alkali-labile linkage. A second group of proteins with N-terminal signal sequences but no covalent attachment sequences are secreted by the classical secretory pathway. These proteins may end up in the cell wall or in the extracellular space. The third group of proteins lack a secretory signal, and the pathway(s) by which they become associated with the surface is unknown. Potential constituents of the first two classes have been predicted from analysis of genome sequences. Experimental analyses have identified members of all three classes. Some members of each class selected for consideration of confirmed or proposed function, phenotypic analysis of a mutant, and regulation by growth conditions and transcription factors are discussed in more detail.

* Mailing address: Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430. Phone: (806) 743-2545. Fax: (806) 743-2334. E-mail: LaJean.Chaffin{at}ttuhsc.edu

Microbiology and Molecular Biology Reviews, September 2008, p. 495-544, Vol. 72, No. 3
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00032-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Birkaya, B., Maddi, A., Joshi, J., Free, S. J., Cullen, P. J. (2009). Role of the Cell Wall Integrity and Filamentous Growth Mitogen-Activated Protein Kinase Pathways in Cell Wall Remodeling during Filamentous Growth. Eukaryot Cell 8: 1118-1133 [Abstract] [Full Text]  


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