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Microbiology and Molecular Biology Reviews, September 2008, p. 545-554, Vol. 72, No. 3
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00007-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response

Eric Guisbert,1,{dagger} Takashi Yura,2 Virgil A. Rhodius,2 and Carol A. Gross2,3*

Departments of Biochemistry and Biophysics,1 Microbiology and Immunology,2 Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 941583

Summary: The heat shock response (HSR) is a homeostatic response that maintains the proper protein-folding environment in the cell. This response is universal, and many of its components are well conserved from bacteria to humans. In this review, we focus on the regulation of one of the most well-characterized HSRs, that of Escherichia coli. We show that even for this simple model organism, we still do not fully understand the central component of heat shock regulation, a chaperone-mediated negative feedback loop. In addition, we review other components that contribute to the regulation of the HSR in E. coli and discuss how these additional components contribute to regulation. Finally, we discuss recent genomic experiments that reveal additional functional aspects of the HSR.

* Corresponding author. Mailing address: Genentech Hall, Room S372E, 600 16th Street, University of California at San Francisco, San Francisco, CA 94158-2517. Phone: (415) 476-4161. Fax: (415) 514-4080. E-mail: cgross{at}cgl.ucsf.edu

{dagger} Present address: Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208.

Microbiology and Molecular Biology Reviews, September 2008, p. 545-554, Vol. 72, No. 3
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00007-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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