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Microbiology and Molecular Biology Reviews, December 2008, p. 579-589, Vol. 72, No. 4
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00025-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Small Toxic Proteins and the Antisense RNAs That Repress Them

Elizabeth M. Fozo,{dagger} Matthew R. Hemm,{dagger} and Gisela Storz*

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, Maryland 20892-5430

Summary: There has been a great expansion in the number of small regulatory RNAs identified in bacteria. Some of these small RNAs repress the synthesis of potentially toxic proteins. Generally the toxin proteins are hydrophobic and less than 60 amino acids in length, and the corresponding antitoxin small RNA genes are antisense to the toxin genes or share long stretches of complementarity with the target mRNAs. Given their short length, only a limited number of these type I toxin-antitoxin loci have been identified, but it is predicted that many remain to be found. Already their characterization has given insights into regulation by small RNAs, has suggested functions for the small toxic proteins at the cell membrane, and has led to practical applications for some of the type I toxin-antitoxin loci.

* Corresponding author. Mailing address: Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, MD 20892-5430. Phone: (301) 402-0968. Fax: (301) 402-0078. E-mail: storz{at}helix.nih.gov

{dagger} These authors contributed equally to this work.

Microbiology and Molecular Biology Reviews, December 2008, p. 579-589, Vol. 72, No. 4
1092-2172/08/$08.00+0     doi:10.1128/MMBR.00025-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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