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Microbiology and Molecular Biology Reviews, September 2009, p. 389-406, Vol. 73, No. 3
1092-2172/09/$08.00+0     doi:10.1128/MMBR.00007-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Aspects of Moraxella catarrhalis Pathogenesis

Stefan P. W. de Vries,1 Hester J. Bootsma,1* John P. Hays,2 and Peter W. M. Hermans1

Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands,1 Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands2

Summary: In recent years, Moraxella catarrhalis has established its position as an important human mucosal pathogen, no longer being regarded as just a commensal bacterium. Further, current research in the field has led to a better understanding of the molecular mechanisms involved in M. catarrhalis pathogenesis, including mechanisms associated with cellular adherence, target cell invasion, modulation of the host's immune response, and metabolism. Additionally, in order to be successful in the host, M. catarrhalis has to be able to interact and compete with the commensal flora and overcome stressful environmental conditions, such as nutrient limitation. In this review, we provide a timely overview of the current understanding of the molecular mechanisms associated with M. catarrhalis virulence and pathogenesis.

* Corresponding author. Mailing address: Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, P.O. Box 9101 (Route 224), 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3666477. Fax: 31-24-3666352. E-mail: H.Bootsma{at}cukz.umcn.nl

Microbiology and Molecular Biology Reviews, September 2009, p. 389-406, Vol. 73, No. 3
1092-2172/09/$08.00+0     doi:10.1128/MMBR.00007-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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