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Microbiology and Molecular Biology Reviews, September 2009, p. 542-563, Vol. 73, No. 3
1092-2172/09/$08.00+0     doi:10.1128/MMBR.00009-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

Michele M. Fluck1* and Brian S. Schaffhausen2*

Department of Microbiology and Molecular Genetics, Interdepartmental Program in Cell and Molecular Biology, Michigan State University, East Lansing, Michigan 48824,1 Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 021112

Summary: The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related signaling. Here we review murine polyomavirus middle T antigen, its mechanisms, and its downstream pathways of transformation. We concentrate on the MMTV-PyMT transgenic mouse, one of the most studied models of breast cancer, which permits the examination of in situ tumor progression from hyperplasia to metastasis.

* Corresponding author. Mailing address for Michele M. Fluck: Department of Microbiology and Molecular Genetics, Interdepartmental Program in Cell and Molecular Biology, Michigan State University, East Lansing, MI 48824. Phone: (517) 884-5327. E-mail: fluck{at}msu.edu. Mailing address for Brian S. Schaffhausen: Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-6868. Fax: (617) 636-2409. E-mail: brian.schaffhausen{at}tufts.edu

Microbiology and Molecular Biology Reviews, September 2009, p. 542-563, Vol. 73, No. 3
1092-2172/09/$08.00+0     doi:10.1128/MMBR.00009-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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