This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Magnuson, K
Right arrow Articles by Cronan, J E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Magnuson, K
Right arrow Articles by Cronan, J E, Jr

 Previous Article  |  Next Article 

Microbiol Mol Biol Rev. 1993 September; 57(3): 522-542

Regulation of fatty acid biosynthesis in Escherichia coli.

K Magnuson, S Jackowski, C O Rock and J E Cronan Jr

Department of Microbiology, University of Illinois, Urbana 61801.

SUMMARY

Our understanding of fatty acid biosynthesis in Escherichia coli has increased greatly in recent years. Since the discovery that the intermediates of fatty acid biosynthesis are bound to the heat-stable protein cofactor termed acyl carrier protein, the fatty acid synthesis pathway of E. coli has been studied in some detail. Interestingly, many advances in the field have aided in the discovery of analogous systems in other organisms. In fact, E. coli has provided a paradigm of predictive value for the synthesis of fatty acids in bacteria and plants and the synthesis of bacterial polyketide antibiotics. In this review, we concentrate on four major areas of research. First, the reactions in fatty acid biosynthesis and the proteins catalyzing these reactions are discussed in detail. The genes encoding many of these proteins have been cloned, and characterization of these genes has led to a better understanding of the pathway. Second, the function and role of the two essential cofactors in fatty acid synthesis, coenzyme A and acyl carrier protein, are addressed. Finally, the steps governing the spectrum of products produced in synthesis and alternative destinations, other than membrane phospholipids, for fatty acids in E. coli are described. Throughout the review, the contribution of each portion of the pathway to the global regulation of synthesis is examined. In no other organism is the bulk of knowledge regarding fatty acid metabolism so great; however, questions still remain to be answered. Pursuing such questions should reveal additional regulatory mechanisms of fatty acid synthesis and, hopefully, the role of fatty acid synthesis and other cellular processes in the global control of cellular growth.

Microbiol Mol Biol Rev. 1993 September; 57(3): 522-542




This article has been cited by other articles:

  • Hankins, J. V., Trent, M. S. (2009). Secondary Acylation of Vibrio cholerae Lipopolysaccharide Requires Phosphorylation of Kdo. J. Biol. Chem. 284: 25804-25812 [Abstract] [Full Text]  
  • Wang, F., Xiao, X., Ou, H.-Y., Gai, Y., Wang, F. (2009). Role and Regulation of Fatty Acid Biosynthesis in the Response of Shewanella piezotolerans WP3 to Different Temperatures and Pressures. J. Bacteriol. 191: 2574-2584 [Abstract] [Full Text]  
  • Bosson, R., Guillas, I., Vionnet, C., Roubaty, C., Conzelmann, A. (2009). Incorporation of Ceramides into Saccharomyces cerevisiae Glycosylphosphatidylinositol-Anchored Proteins Can Be Monitored In Vitro. Eukaryot Cell 8: 306-314 [Abstract] [Full Text]  
  • Bainbridge, B. W., Karimi-Naser, L., Reife, R., Blethen, F., Ernst, R. K., Darveau, R. P. (2008). Acyl Chain Specificity of the Acyltransferases LpxA and LpxD and Substrate Availability Contribute to Lipid A Fatty Acid Heterogeneity in Porphyromonas gingivalis. J. Bacteriol. 190: 4549-4558 [Abstract] [Full Text]  
  • Kizer, L., Pitera, D. J., Pfleger, B. F., Keasling, J. D. (2008). Application of Functional Genomics to Pathway Optimization for Increased Isoprenoid Production. Appl. Environ. Microbiol. 74: 3229-3241 [Abstract] [Full Text]  
  • Matsuoka, H., Hirooka, K., Fujita, Y. (2007). Organization and Function of the YsiA Regulon of Bacillus subtilis Involved in Fatty Acid Degradation. J. Biol. Chem. 282: 5180-5194 [Abstract] [Full Text]  
  • Mouttaki, H., Nanny, M. A., McInerney, M. J. (2007). Cyclohexane Carboxylate and Benzoate Formation from Crotonate in Syntrophus aciditrophicus. Appl. Environ. Microbiol. 73: 930-938 [Abstract] [Full Text]  
  • Rafi, S., Novichenok, P., Kolappan, S., Zhang, X., Stratton, C. F., Rawat, R., Kisker, C., Simmerling, C., Tonge, P. J. (2006). Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli. J. Biol. Chem. 281: 39285-39293 [Abstract] [Full Text]  
  • Mazumdar, J., H. Wilson, E., Masek, K., A. Hunter, C., Striepen, B. (2006). Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc. Natl. Acad. Sci. USA 103: 13192-13197 [Abstract] [Full Text]  
  • Cho, B.-K., Knight, E. M., Palsson, B. O. (2006). Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA.. Microbiology 152: 2207-2219 [Abstract] [Full Text]  
  • Raetz, C. R. H., Garrett, T. A., Reynolds, C. M., Shaw, W. A., Moore, J. D., Smith, D. C. Jr., Ribeiro, A. A., Murphy, R. C., Ulevitch, R. J., Fearns, C., Reichart, D., Glass, C. K., Benner, C., Subramaniam, S., Harkewicz, R., Bowers-Gentry, R. C., Buczynski, M. W., Cooper, J. A., Deems, R. A., Dennis, E. A. (2006). Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J. Lipid Res. 47: 1097-1111 [Abstract] [Full Text]  
  • Peric-Concha, N., Borovicka, B., Long, P. F., Hranueli, D., Waterman, P. G., Hunter, I. S. (2005). Ablation of the otcC Gene Encoding a Post-polyketide Hydroxylase from the Oxytetracyline Biosynthetic Pathway in Streptomyces rimosus Results in Novel Polyketides with Altered Chain Length. J. Biol. Chem. 280: 37455-37460 [Abstract] [Full Text]  
  • Eichler, J., Adams, M. W. W. (2005). Posttranslational Protein Modification in Archaea. Microbiol. Mol. Biol. Rev. 69: 393-425 [Abstract] [Full Text]  
  • Tan, X.-X., Actor, J. K., Chen, Y. (2005). Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection. Antimicrob. Agents Chemother. 49: 3203-3207 [Abstract] [Full Text]  
  • Heipieper, H. J., Chiou, R. Y.-Y. (2005). Adaptation of Escherichia coli to Ethanol on the Level of Membrane Fatty Acid Composition. Appl. Environ. Microbiol. 71: 3388-3388 [Full Text]  
  • Li, Y., Florova, G., Reynolds, K. A. (2005). Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH). J. Bacteriol. 187: 3795-3799 [Abstract] [Full Text]  
  • Campobasso, N., Patel, M., Wilding, I. E., Kallender, H., Rosenberg, M., Gwynn, M. N. (2004). Staphylococcus aureus 3-Hydroxy-3-methylglutaryl-CoA Synthase: CRYSTAL STRUCTURE AND MECHANISM. J. Biol. Chem. 279: 44883-44888 [Abstract] [Full Text]  
  • Wang, H., Cronan, J. E. (2004). Functional Replacement of the FabA and FabB Proteins of Escherichia coli Fatty Acid Synthesis by Enterococcus faecalis FabZ and FabF Homologues. J. Biol. Chem. 279: 34489-34495 [Abstract] [Full Text]  
  • He, X., Reeve, A. M., Desai, U. R., Kellogg, G. E., Reynolds, K. A. (2004). 1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH). Antimicrob. Agents Chemother. 48: 3093-3102 [Abstract] [Full Text]  
  • Zheng, Z., Gong, Q., Liu, T., Deng, Y., Chen, J.-C., Chen, G.-Q. (2004). Thioesterase II of Escherichia coli Plays an Important Role in 3-Hydroxydecanoic Acid Production. Appl. Environ. Microbiol. 70: 3807-3813 [Abstract] [Full Text]  
  • Que-Gewirth, N. L. S., Ribeiro, A. A., Kalb, S. R., Cotter, R. J., Bulach, D. M., Adler, B., Girons, I. S., Werts, C., Raetz, C. R. H. (2004). A Methylated Phosphate Group and Four Amide-linked Acyl Chains in Leptospira interrogans Lipid A: THE MEMBRANE ANCHOR OF AN UNUSUAL LIPOPOLYSACCHARIDE THAT ACTIVATES TLR2. J. Biol. Chem. 279: 25420-25429 [Abstract] [Full Text]  
  • Lai, C.-Y., Cronan, J. E. (2004). Isolation and Characterization of {beta}-Ketoacyl-Acyl Carrier Protein Reductase (fabG) Mutants of Escherichia coli and Salmonella enterica Serovar Typhimurium. J. Bacteriol. 186: 1869-1878 [Abstract] [Full Text]  
  • Londry, K. L., Jahnke, L. L., Des Marais, D. J. (2004). Stable Carbon Isotope Ratios of Lipid Biomarkers of Sulfate-Reducing Bacteria. Appl. Environ. Microbiol. 70: 745-751 [Abstract] [Full Text]  
  • Fozo, E. M., Quivey, R. G. Jr. (2004). Shifts in the Membrane Fatty Acid Profile of Streptococcus mutans Enhance Survival in Acidic Environments. Appl. Environ. Microbiol. 70: 929-936 [Abstract] [Full Text]  
  • Raychaudhuri, S., Rajasekharan, R. (2003). Nonorganellar Acyl Carrier Protein from Oleaginous Yeast Is a Homologue of Ribosomal Protein P2. J. Biol. Chem. 278: 37648-37657 [Abstract] [Full Text]  
  • Kremer, L., Guerardel, Y., Gurcha, S. S., Locht, C., Besra, G. S. (2002). Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile. Microbiology 148: 3145-3154 [Abstract] [Full Text]  
  • Basu, S. S., Karbarz, M. J., Raetz, C. R. H. (2002). Expression Cloning and Characterization of the C28 Acyltransferase of Lipid A Biosynthesis in Rhizobium leguminosarum. J. Biol. Chem. 277: 28959-28971 [Abstract] [Full Text]  
  • He, X., Reynolds, K. A. (2002). Purification, Characterization, and Identification of Novel Inhibitors of the {beta}-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus. Antimicrob. Agents Chemother. 46: 1310-1318 [Abstract] [Full Text]  
  • Campbell, J. W., Cronan, J. E. Jr. (2001). Escherichia coli FadR Positively Regulates Transcription of the fabB Fatty Acid Biosynthetic Gene. J. Bacteriol. 183: 5982-5990 [Abstract] [Full Text]  
  • Sugai, R., Shimizu, H., Nishiyama, K.-i., Tokuda, H. (2001). Overexpression of yccL (gnsA) and ydfY (gnsB) Increases Levels of Unsaturated Fatty Acids and Suppresses both the Temperature-Sensitive fabA6 Mutation and Cold-Sensitive secG Null Mutation of Escherichia coli. J. Bacteriol. 183: 5523-5528 [Abstract] [Full Text]  
  • Metz, J. G., Roessler, P., Facciotti, D., Levering, C., Dittrich, F., Lassner, M., Valentine, R., Lardizabal, K., Domergue, F., Yamada, A., Yazawa, K., Knauf, V., Browse, J. (2001). Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes. Science 293: 290-293 [Abstract] [Full Text]  
  • Parrish, N. M., Houston, T., Jones, P. B., Townsend, C., Dick, J. D. (2001). In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis. Antimicrob. Agents Chemother. 45: 1143-1150 [Abstract] [Full Text]  
  • Smirnova, N., Reynolds, K. A. (2001). Engineered Fatty Acid Biosynthesis in Streptomyces by Altered Catalytic Function of {beta}-Ketoacyl-Acyl Carrier Protein Synthase III. J. Bacteriol. 183: 2335-2342 [Abstract] [Full Text]  
  • Kiatpapan, P., Kobayashi, H., Sakaguchi, M., Ono, H., Yamashita, M., Kaneko, Y., Murooka, Y. (2001). Molecular Characterization of Lactobacillus plantarum Genes for {beta}-Ketoacyl-Acyl Carrier Protein Synthase III (fabH) and Acetyl Coenzyme A Carboxylase (accBCDA), Which Are Essential for Fatty Acid Biosynthesis. Appl. Environ. Microbiol. 67: 426-433 [Abstract] [Full Text]  
  • Nakahara, T., Zhang, Q.-M., Hashiguchi, K., Yonei, S. (2000). Identification of proteins of Escherichia coli and Saccharomyces cerevisiae that specifically bind to C/C mismatches in DNA. Nucleic Acids Res 28: 2551-2556 [Abstract] [Full Text]  
  • Nichols, D. S., Olley, J., Garda, H., Brenner, R. R., McMeekin, T. A. (2000). Effect of Temperature and Salinity Stress on Growth and Lipid Composition of Shewanella gelidimarina. Appl. Environ. Microbiol. 66: 2422-2429 [Abstract] [Full Text]  
  • Morita, Y. S., Paul, K. S., Englund, P. T. (2000). Specialized Fatty Acid Synthesis in African Trypanosomes: Myristate for GPI Anchors. Science 288: 140-143 [Abstract] [Full Text]  
  • Flugel, R. S., Hwangbo, Y., Lambalot, R. H., Cronan, J. E. Jr., Walsh, C. T. (2000). Holo-(Acyl Carrier Protein) Synthase and Phosphopantetheinyl Transfer in Escherichia coli. J. Biol. Chem. 275: 959-968 [Abstract] [Full Text]  
  • Qiu, X., Janson, C. A., Konstantinidis, A. K., Nwagwu, S., Silverman, C., Smith, W. W., Khandekar, S., Lonsdale, J., Abdel-Meguid, S. S. (1999). Crystal Structure of beta -Ketoacyl-Acyl Carrier Protein Synthase III. A KEY CONDENSING ENZYME IN BACTERIAL FATTY ACID BIOSYNTHESIS. J. Biol. Chem. 274: 36465-36471 [Abstract] [Full Text]  
  • Wilson, M., DeRisi, J., Kristensen, H.-H., Imboden, P., Rane, S., Brown, P. O., Schoolnik, G. K. (1999). Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization. Proc. Natl. Acad. Sci. USA 96: 12833-12838 [Abstract] [Full Text]  
  • Hoang, T. T., Schweizer, H. P. (1999). Characterization of Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI): a Target for the Antimicrobial Triclosan and Its Role in Acylated Homoserine Lactone Synthesis. J. Bacteriol. 181: 5489-5497 [Abstract] [Full Text]  
  • Yu, T.-W., Shen, Y., Doi-Katayama, Y., Tang, L., Park, C., Moore, B. S., Richard Hutchinson, C., Floss, H. G. (1999). Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proc. Natl. Acad. Sci. USA 96: 9051-9056 [Abstract] [Full Text]  
  • Prieto, M. A., Kellerhals, M. B., Bozzato, G. B., Radnovic, D., Witholt, B., Kessler, B. (1999). Engineering of Stable Recombinant Bacteria for Production of Chiral Medium-Chain-Length Poly-3-Hydroxyalkanoates. Appl. Environ. Microbiol. 65: 3265-3271 [Abstract] [Full Text]  
  • Bao, W., Sheldon, P. J., Wendt-Pienkowski, E., Hutchinson, C. R. (1999). The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide. J. Bacteriol. 181: 4690-4695 [Abstract] [Full Text]  
  • Darwin, K. H., Miller, V. L. (1999). Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa. Clin. Microbiol. Rev. 12: 405-428 [Abstract] [Full Text]  
  • Phetsuksiri, B., Baulard, A. R., Cooper, A. M., Minnikin, D. E., Douglas, J. D., Besra, G. S., Brennan, P. J. (1999). Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis. Antimicrob. Agents Chemother. 43: 1042-1051 [Abstract] [Full Text]  
  • Carty, S. M., Sreekumar, K. R., Raetz, C. R. H. (1999). Effect of Cold Shock on Lipid A Biosynthesis in Escherichia coli. INDUCTION AT 12 °C OF AN ACYLTRANSFERASE SPECIFIC FOR PALMITOLEOYL-ACYL CARRIER PROTEIN. J. Biol. Chem. 274: 9677-9685 [Abstract] [Full Text]  
  • Moche, M., Schneider, G., Edwards, P., Dehesh, K., Lindqvist, Y. (1999). Structure of the Complex between the Antibiotic Cerulenin and Its Target, beta -Ketoacyl-Acyl Carrier Protein Synthase. J. Biol. Chem. 274: 6031-6034 [Abstract] [Full Text]  
  • Berlyn, M. K. B. (1998). Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map. Microbiol. Mol. Biol. Rev. 62: 814-984 [Abstract] [Full Text]  
  • Han, L., Lobo, S., Reynolds, K. A. (1998). Characterization of beta -Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis. J. Bacteriol. 180: 4481-4486 [Abstract] [Full Text]  
  • Subrahmanyam, S., Cronan, J. E. Jr. (1998). Overproduction of a Functional Fatty Acid Biosynthetic Enzyme Blocks Fatty Acid Synthesis in Escherichia coli. J. Bacteriol. 180: 4596-4602 [Abstract] [Full Text]  
  • Zhang, Y., Cronan, J. E. Jr. (1998). Transcriptional Analysis of Essential Genes of the Escherichia coli Fatty Acid Biosynthesis Gene Cluster by Functional Replacement with the Analogous Salmonella typhimurium Gene Cluster. J. Bacteriol. 180: 3295-3303 [Abstract] [Full Text]  
  • Stanley, P., Koronakis, V., Hughes, C. (1998). Acylation of Escherichia coli Hemolysin: A Unique Protein Lipidation Mechanism Underlying Toxin Function. Microbiol. Mol. Biol. Rev. 62: 309-333 [Abstract] [Full Text]  
  • Val, D. L., Cronan, J. E. Jr. (1998). In Vivo Evidence that S-Adenosylmethionine and Fatty Acid Synthesis Intermediates Are the Substrates for the LuxI Family of Autoinducer Synthases. J. Bacteriol. 180: 2644-2651 [Abstract] [Full Text]  
  • Joshi, A. K., Rangan, V. S., Smith, S. (1998). Differential Affinity Labeling of the Two Subunits of the Homodimeric Animal Fatty Acid Synthase Allows Isolation of Heterodimers Consisting of Subunits That Have Been Independently Modified. J. Biol. Chem. 273: 4937-4943 [Abstract] [Full Text]  
  • Dotson, G. D., Kaltashov, I. A., Cotter, R. J., Raetz, C. R. H. (1998). Expression Cloning of a Pseudomonas Gene Encoding a Hydroxydecanoyl-Acyl Carrier Protein-Dependent UDP-GlcNAc Acyltransferase. J. Bacteriol. 180: 330-337 [Abstract] [Full Text]  
  • Odegaard, T. J., Kaltashov, I. A., Cotter, R. J., Steeghs, L., van der Ley, P., Khan, S., Maskell, D. J., Raetz, C. R. H. (1997). Shortened Hydroxyacyl Chains on Lipid A of Escherichia coli Cells Expressing a Foreign UDP-N-Acetylglucosamine O-Acyltransferase. J. Biol. Chem. 272: 19688-19696 [Abstract] [Full Text]  
  • Jordan, S. W., Cronan Jr., J. E. (1997). A New Metabolic Link. THE ACYL CARRIER PROTEIN OF LIPID SYNTHESIS DONATES LIPOIC ACID TO THE PYRUVATE DEHYDROGENASE COMPLEX IN ESCHERICHIA COLI AND MITOCHONDRIA. J. Biol. Chem. 272: 17903-17906 [Abstract] [Full Text]  
  • Brozek, K. A., Carlson, R. W., Raetz, C. R.H. (1996). A Special Acyl Carrier Protein for Transferring Long Hydroxylated Fatty Acids to Lipid A in Rhizobium. J. Biol. Chem. 271: 32126-32136 [Abstract] [Full Text]  
  • Heath, RichardJ., Rock, CharlesO. (1996). Roles of the FabA and FabZ beta -Hydroxyacyl-Acyl Carrier Protein Dehydratases in Escherichia coli Fatty Acid Biosynthesis. J. Biol. Chem. 271: 27795-27801 [Abstract] [Full Text]  
  • Sorensen, P. G., Lutkenhaus, J., Young, K., Eveland, S. S., Anderson, M. S., Raetz, C. R.H. (1996). Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine Deacetylase in Escherichia coli. THE SECOND ENZYMATIC STEP OF LIPID A BIOSYNTHESIS. J. Biol. Chem. 271: 25898-25905 [Abstract] [Full Text]  
  • Mayer, H., Merkofer, T., Warth, C., Weckesser, J. (1996). Position and configuration of double bonds of lipid A-associated monounsaturated fatty acids of Proteobacferia and Rhodobacter capsulatus 37b4. Innate Immunity 3: 345-352 [Abstract]  
  • Keating, DavidH., Cronan, JohnE. Jr. (1996). An Isoleucine to Valine Substitution in Escherichia coli Acyl Carrier Protein Results in a Functional Protein of Decreased Molecular Radius at Elevated pH. J. Biol. Chem. 271: 15905-15910 [Abstract] [Full Text]  
  • Flint, D. H., Flint, D. H. (1996). Escherichia coli Contains a Protein That Is Homologous in Function and N-terminal Sequence to the Protein Encoded by the nifS Gene of Azotobacter vinelandii and That Can Participate in the Synthesis of the Fe-S Cluster of Dihydroxy-acid Dehydratase. J. Biol. Chem. 271: 16068-16074 [Abstract] [Full Text]  
  • Heath, R. J., Rock, C. O. (1996). Inhibition of beta-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) by Acyl-Acyl Carrier Protein in Escherichia coli. J. Biol. Chem. 271: 10996-11000 [Abstract] [Full Text]  
  • Morein, S., Andersson, A.-S., Rilfors, L., Lindblom, Gör. (1996). Wild-type Escherichia coli Cells Regulate the Membrane Lipid Composition in a ``Window'' between Gel and Non-lamellar Structures. J. Biol. Chem. 271: 6801-6809 [Abstract] [Full Text]  
  • Heath, R. J., Rock, C. O. (1996). Regulation of Fatty Acid Elongation and Initiation by Acyl-Acyl Carrier Protein in Escherichia coli. J. Biol. Chem. 271: 1833-1836 [Abstract] [Full Text]  
  • Heath, R. J., Rock, C. O. (1995). Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli. J. Biol. Chem. 270: 26538-26542 [Abstract] [Full Text]  
  • Keating, D. H., Carey, M. R., Cronan, J. E. , Jr. (1995). The Unmodified (Apo) Form of Escherichia coli Acyl Carrier Protein Is a Potent Inhibitor of Cell Growth. J. Biol. Chem. 270: 22229-22235 [Abstract] [Full Text]  
  • Heath, R. J., Rock, C. O. (1995). Regulation of Malonyl-CoA Metabolism by Acyl-Acyl Carrier Protein and [IMAGE]-Ketoacyl-Acyl Carrier Protein Synthases in Escherichia coli. J. Biol. Chem. 270: 15531-15538 [Abstract] [Full Text]  
  • Serre, L., Verbree, E. C., Dauter, Z., Stuitje, A. R., Derewenda, Z. S. (1995). The Escherichia coli Malonyl-CoA:Acyl Carrier Protein Transacylase at 1.5-Å Resolution. J. Biol. Chem. 270: 12961-12964 [Abstract] [Full Text]  
  • Cho, H., Cronan, J. E. Jr. (1995). Defective Export of a Periplasmic Enzyme Disrupts Regulation of Fatty Acid Synthesis. J. Biol. Chem. 270: 4216-4219 [Abstract] [Full Text]  
  • Shen, B, Hutchinson, C. (1993). Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. Science 262: 1535-1540 [Abstract]  
  • Doerrler, W. T., Reedy, M. C., Raetz, C. R. H. (2001). An Escherichia coli Mutant Defective in Lipid Export. J. Biol. Chem. 276: 11461-11464 [Abstract] [Full Text]  
  • Kremer, L., Douglas, J. D., Baulard, A. R., Morehouse, C., Guy, M. R., Alland, D., Dover, L. G., Lakey, J. H., Jacobs, W. R. Jr., Brennan, P. J., Minnikin, D. E., Besra, G. S. (2000). Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes in Mycobacterium tuberculosis. J. Biol. Chem. 275: 16857-16864 [Abstract] [Full Text]  
  • Choi, K.-H., Kremer, L., Besra, G. S., Rock, C. O. (2000). Identification and Substrate Specificity of beta -Ketoacyl (Acyl Carrier Protein) Synthase III (mtFabH) from Mycobacterium tuberculosis. J. Biol. Chem. 275: 28201-28207 [Abstract] [Full Text]  
  • Scarsdale, J. N., Kazanina, G., He, X., Reynolds, K. A., Wright, H. T. (2001). Crystal Structure of the Mycobacterium tuberculosisbeta -Ketoacyl-Acyl Carrier Protein Synthase III. J. Biol. Chem. 276: 20516-20522 [Abstract] [Full Text]  
  • Khandekar, S. S., Gentry, D. R., Van Aller, G. S., Warren, P., Xiang, H., Silverman, C., Doyle, M. L., Chambers, P. A., Konstantinidis, A. K., Brandt, M., Daines, R. A., Lonsdale, J. T. (2001). Identification, Substrate Specificity, and Inhibition of the Streptococcus pneumoniaebeta -Ketoacyl-Acyl Carrier Protein Synthase III (FabH). J. Biol. Chem. 276: 30024-30030 [Abstract] [Full Text]  
  • Kremer, L., Nampoothiri, K. M., Lesjean, S., Dover, L. G., Graham, S., Betts, J., Brennan, P. J., Minnikin, D. E., Locht, C., Besra, G. S. (2001). Biochemical Characterization of Acyl Carrier Protein (AcpM) and Malonyl-CoA:AcpM Transacylase (mtFabD), Two Major Components of Mycobacterium tuberculosis Fatty Acid Synthase II. J. Biol. Chem. 276: 27967-27974 [Abstract] [Full Text]  
  • Cronan, J. E. Jr. (2001). The Biotinyl Domain of Escherichia coli Acetyl-CoA Carboxylase. EVIDENCE THAT THE "THUMB" STRUCTURE IS ESSENTIAL AND THAT THE DOMAIN FUNCTIONS AS A DIMER. J. Biol. Chem. 276: 37355-37364 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»