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Microbiol. Rev., Jun 1996, 301-315, Vol 60, No. 2
Copyright © 1996, American Society for Microbiology

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy

SR Meshnick, TE Taylor and S Kamchonwongpaisan
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA. meshnick@umich.edu

Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.


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