This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thomas, D. Articles by Surdin-Kerjan, Y. Search for Related Content PubMed PubMed Citation Articles by Thomas, D. Articles by Surdin-Kerjan, Y.

 Previous Article  |  Next Article 

Microbiol. Mol. Biol. Rev., 12 1997, 503-532, Vol 61, No. 4
Copyright © 1997, American Society for Microbiology

Metabolism of sulfur amino acids in Saccharomyces cerevisiae [In Process Citation]

D Thomas and Y Surdin-Kerjan
Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France.

Sulfur amino acid biosynthesis in Saccharomyces cerevisiae involves a large number of enzymes required for the de novo biosynthesis of methionine and cysteine and the recycling of organic sulfur metabolites. This review summarizes the details of these processes and analyzes the molecular data which have been acquired in this metabolic area. Sulfur biochemistry appears not to be unique through terrestrial life, and S. cerevisiae is one of the species of sulfate-assimilatory organisms possessing a larger set of enzymes for sulfur metabolism. The review also deals with several enzyme deficiencies that lead to a nutritional requirement for organic sulfur, although they do not correspond to defects within the biosynthetic pathway. In S. cerevisiae, the sulfur amino acid biosynthetic pathway is tightly controlled: in response to an increase in the amount of intracellular S- adenosylmethionine (AdoMet), transcription of the coregulated genes is turned off. The second part of the review is devoted to the molecular mechanisms underlying this regulation. The coordinated response to AdoMet requires two cis-acting promoter elements. One centers on the sequence TCACGTG, which also constitutes a component of all S. cerevisiae centromeres. Situated upstream of the sulfur genes, this element is the binding site of a transcription activation complex consisting of a basic helix-loop-helix factor, Cbf1p, and two basic leucine zipper factors, Met4p and Met28p. Molecular studies have unraveled the specific functions for each subunit of the Cbf1p-Met4p- Met28p complex as well as the modalities of its assembly on the DNA. The Cbf1p-Met4p-Met28p complex contains only one transcription activation module, the Met4p subunit. Detailed mutational analysis of Met4p has elucidated its functional organization. In addition to its activation and bZIP domains, Met4p contains two regulatory domains, called the inhibitory region and the auxiliary domain. When the level of intracellular AdoMet increases, the transcription activation function of Met4 is prevented by Met30p, which binds to the Met4 inhibitory region. In addition to the Cbf1p-Met4p-Met28p complex, transcriptional regulation involves two zinc finger-containing proteins, Met31p and Met32p. The AdoMet-mediated control of the sulfur amino acid pathway illustrates the molecular strategies used by eucaryotic cells to couple gene expression to metabolic changes.

This article has been cited by other articles:

• Pereira, Y., Lagniel, G., Godat, E., Baudouin-Cornu, P., Junot, C., Labarre, J. (2008). Chromate Causes Sulfur Starvation in Yeast. Toxicol Sci 106: 400-412 [Abstract] [Full Text]  
• Ito, S., Nagamune, H., Tamura, H., Yoshida, Y. (2008). Identification and molecular analysis of {beta}C-S lyase producing hydrogen sulfide in Streptococcus intermedius. J Med Microbiol 57: 1411-1419 [Abstract] [Full Text]  
• Thompson, D. M., Lu, C., Green, P. J., Parker, R. (2008). tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA 14: 2095-2103 [Abstract] [Full Text]  
• Andre, G., Even, S., Putzer, H., Burguiere, P., Croux, C., Danchin, A., Martin-Verstraete, I., Soutourina, O. (2008). S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum. Nucleic Acids Res 36: 5955-5969 [Abstract] [Full Text]  
• Malanovic, N., Streith, I., Wolinski, H., Rechberger, G., Kohlwein, S. D., Tehlivets, O. (2008). S-Adenosyl-L-homocysteine Hydrolase, Key Enzyme of Methylation Metabolism, Regulates Phosphatidylcholine Synthesis and Triacylglycerol Homeostasis in Yeast: IMPLICATIONS FOR HOMOCYSTEINE AS A RISK FACTOR OF ATHEROSCLEROSIS. J. Biol. Chem. 283: 23989-23999 [Abstract] [Full Text]  
• Banuelos, M. A., Haro, R., Fraile-Escanciano, A., Rodriguez-Navarro, A. (2008). Effects of Polylinker uATGs on the Function of Grass HKT1 Transporters Expressed in Yeast Cells. Plant Cell Physiol 49: 1128-1132 [Abstract] [Full Text]  
• Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Sugihara, M., Imai, T., Ishiguro, T., Mizutani, S., Tomita, M., Soga, T., Yoshimoto, H. (2008). Development of Bottom-Fermenting Saccharomyces Strains That Produce High SO2 Levels, Using Integrated Metabolome and Transcriptome Analysis. Appl. Environ. Microbiol. 74: 2787-2796 [Abstract] [Full Text]  
• Su, N.-Y., Ouni, I., Papagiannis, C. V., Kaiser, P. (2008). A Dominant Suppressor Mutation of the met30 Cell Cycle Defect Suggests Regulation of the Saccharomyces cerevisiae Met4-Cbf1 Transcription Complex by Met32. J. Biol. Chem. 283: 11615-11624 [Abstract] [Full Text]  
• Kim, J., Kim, H. (2008). Clustering of change patterns using Fourier coefficients. Bioinformatics 24: 184-191 [Abstract] [Full Text]  
• Tu, B. P., Mohler, R. E., Liu, J. C., Dombek, K. M., Young, E. T., Synovec, R. E., McKnight, S. L. (2007). Cyclic changes in metabolic state during the life of a yeast cell. Proc. Natl. Acad. Sci. USA 104: 16886-16891 [Abstract] [Full Text]  
• Thorsen, M., Lagniel, G., Kristiansson, E., Junot, C., Nerman, O., Labarre, J., Tamas, M. J. (2007). Quantitative transcriptome, proteome, and sulfur metabolite profiling of the Saccharomyces cerevisiae response to arsenite. Physiol. Genomics 30: 35-43 [Abstract] [Full Text]  
• Kaur, J., Bachhawat, A. K. (2007). Yct1p, a Novel, High-Affinity, Cysteine-Specific Transporter From the Yeast Saccharomyces cerevisiae. Genetics 176: 877-890 [Abstract] [Full Text]  
• Malkowski, M. G., Quartley, E., Friedman, A. E., Babulski, J., Kon, Y., Wolfley, J., Said, M., Luft, J. R., Phizicky, E. M., DeTitta, G. T., Grayhack, E. J. (2007). Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Proc. Natl. Acad. Sci. USA 104: 6678-6683 [Abstract] [Full Text]  
• Godard, P., Urrestarazu, A., Vissers, S., Kontos, K., Bontempi, G., van Helden, J., Andre, B. (2007). Effect of 21 Different Nitrogen Sources on Global Gene Expression in the Yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 27: 3065-3086 [Abstract] [Full Text]  
• Lechenne, B., Reichard, U., Zaugg, C., Fratti, M., Kunert, J., Boulat, O., Monod, M. (2007). Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes. Microbiology 153: 905-913 [Abstract] [Full Text]  
• Murray, D. B., Beckmann, M., Kitano, H. (2007). Regulation of yeast oscillatory dynamics. Proc. Natl. Acad. Sci. USA 104: 2241-2246 [Abstract] [Full Text]  
• Hullo, M.-F., Auger, S., Soutourina, O., Barzu, O., Yvon, M., Danchin, A., Martin-Verstraete, I. (2007). Conversion of Methionine to Cysteine in Bacillus subtilis and Its Regulation. J. Bacteriol. 189: 187-197 [Abstract] [Full Text]  
• Barreto, L., Garcera, A., Jansson, K., Sunnerhagen, P., Herrero, E. (2006). A Peroxisomal Glutathione Transferase of Saccharomyces cerevisiae Is Functionally Related to Sulfur Amino Acid Metabolism. Eukaryot Cell 5: 1748-1759 [Abstract] [Full Text]  
• Seiflein, T. A., Lawrence, J. G. (2006). Two Transsulfurylation Pathways in Klebsiella pneumoniae.. J. Bacteriol. 188: 5762-5774 [Abstract] [Full Text]  
• Menant, A., Baudouin-Cornu, P., Peyraud, C., Tyers, M., Thomas, D. (2006). Determinants of the Ubiquitin-mediated Degradation of the Met4 Transcription Factor. J. Biol. Chem. 281: 11744-11754 [Abstract] [Full Text]  
• Leroy, C., Cormier, L., Kuras, L. (2006). Independent Recruitment of Mediator and SAGA by the Activator Met4. Mol. Cell. Biol. 26: 3149-3163 [Abstract] [Full Text]  
• Todeschini, A.-L., Condon, C., Benard, L. (2006). Sodium-induced GCN4 Expression Controls the Accumulation of the 5' to 3' RNA Degradation Inhibitor, 3'-Phosphoadenosine 5'-Phosphate. J. Biol. Chem. 281: 3276-3282 [Abstract] [Full Text]  
• Fujita, Y., Ukena, E., Iefuji, H., Giga-Hama, Y., Takegawa, K. (2006). Homocysteine accumulation causes a defect in purine biosynthesis: further characterization of Schizosaccharomyces pombe methionine auxotrophs. Microbiology 152: 397-404 [Abstract] [Full Text]  
• Aggarwal, M., Mondal, A. K. (2006). Role of N-Terminal Hydrophobic Region in Modulating the Subcellular Localization and Enzyme Activity of the Bisphosphate Nucleotidase from Debaryomyces hansenii. Eukaryot Cell 5: 262-271 [Abstract] [Full Text]  
• Zuzuarregui, A., Monteoliva, L., Gil, C., del Olmo, M.{m. d.}l. (2006). Transcriptomic and Proteomic Approach for Understanding the Molecular Basis of Adaptation of Saccharomyces cerevisiae to Wine Fermentation. Appl. Environ. Microbiol. 72: 836-847 [Abstract] [Full Text]  
• Vignols, F., Brehelin, C., Surdin-Kerjan, Y., Thomas, D., Meyer, Y. (2005). A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteins in vivo. Proc. Natl. Acad. Sci. USA 102: 16729-16734 [Abstract] [Full Text]  
• Onodera, J., Ohsumi, Y. (2005). Autophagy Is Required for Maintenance of Amino Acid Levels and Protein Synthesis under Nitrogen Starvation. J. Biol. Chem. 280: 31582-31586 [Abstract] [Full Text]  
• Howell, K. S., Klein, M., Swiegers, J. H., Hayasaka, Y., Elsey, G. M., Fleet, G. H., Hoj, P. B., Pretorius, I. S., de Barros Lopes, M. A. (2005). Genetic Determinants of Volatile-Thiol Release by Saccharomyces cerevisiae during Wine Fermentation. Appl. Environ. Microbiol. 71: 5420-5426 [Abstract] [Full Text]  
• Gonze, D., Pinloche, S., Gascuel, O., van Helden, J. (2005). Discrimination of yeast genes involved in methionine and phosphate metabolism on the basis of upstream motifs. Bioinformatics 21: 3490-3500 [Abstract] [Full Text]  
• Srikantha, T., Zhao, R., Daniels, K., Radke, J., Soll, D. R. (2005). Phenotypic Switching in Candida glabrata Accompanied by Changes in Expression of Genes with Deduced Functions in Copper Detoxification and Stress. Eukaryot Cell 4: 1434-1445 [Abstract] [Full Text]  
• Lafaye, A., Junot, C., Pereira, Y., Lagniel, G., Tabet, J.-C., Ezan, E., Labarre, J. (2005). Combined Proteome and Metabolite-profiling Analyses Reveal Surprising Insights into Yeast Sulfur Metabolism. J. Biol. Chem. 280: 24723-24730 [Abstract] [Full Text]  
• Hirano, W., Gotoh, I., Uekita, T., Seiki, M. (2005). Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. GENES CELLS 10: 565-574 [Abstract] [Full Text]  
• Su, N. Y., Flick, K., Kaiser, P. (2005). The F-Box Protein Met30 Is Required for Multiple Steps in the Budding Yeast Cell Cycle. Mol. Cell. Biol. 25: 3875-3885 [Abstract] [Full Text]  
• Yen, J. L., Su, N.-Y., Kaiser, P. (2005). The Yeast Ubiquitin Ligase SCFMet30 Regulates Heavy Metal Response. Mol. Biol. Cell 16: 1872-1882 [Abstract] [Full Text]  
• Sauter, M., Cornell, K. A., Beszteri, S., Rzewuski, G. (2004). Functional Analysis of Methylthioribose Kinase Genes in Plants. Plant Physiol. 136: 4061-4071 [Abstract] [Full Text]  
• Pascon, R. C., Ganous, T. M., Kingsbury, J. M., Cox, G. M., McCusker, J. H. (2004). Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. Microbiology 150: 3013-3023 [Abstract] [Full Text]  
• Saldanha, A. J., Brauer, M. J., Botstein, D. (2004). Nutritional Homeostasis in Batch and Steady-State Culture of Yeast. Mol. Biol. Cell 15: 4089-4104 [Abstract] [Full Text]  
• Kolaczkowski, M., Kolaczkowska, A., Gaigg, B., Schneiter, R., Moye-Rowley, W. S. (2004). Differential Regulation of Ceramide Synthase Components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell 3: 880-892 [Abstract] [Full Text]  
• Maruyama-Nakashita, A., Nakamura, Y., Yamaya, T., Takahashi, H. (2004). Regulation of high-affinity sulphate transporters in plants: towards systematic analysis of sulphur signalling and regulation. J Exp Bot 55: 1843-1849 [Abstract] [Full Text]  
• Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., Gelfand, M. S. (2004). Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems. Nucleic Acids Res 32: 3340-3353 [Abstract] [Full Text]  
• Mizunuma, M., Miyamura, K., Hirata, D., Yokoyama, H., Miyakawa, T. (2004). Involvement of S-adenosylmethionine in G1 cell-cycle regulation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 101: 6086-6091 [Abstract] [Full Text]  
• Aranda, A., del Olmo, M.-l. (2004). Exposure of Saccharomyces cerevisiae to Acetaldehyde Induces Sulfur Amino Acid Metabolism and Polyamine Transporter Genes, Which Depend on Met4p and Haa1p Transcription Factors, Respectively. Appl. Environ. Microbiol. 70: 1913-1922 [Abstract] [Full Text]  
• Garcia-Sanchez, S., Aubert, S., Iraqui, I., Janbon, G., Ghigo, J.-M., d'Enfert, C. (2004). Candida albicans Biofilms: a Developmental State Associated With Specific and Stable Gene Expression Patterns. Eukaryot Cell 3: 536-545 [Abstract] [Full Text]  
• Borkovich, K. A., Alex, L. A., Yarden, O., Freitag, M., Turner, G. E., Read, N. D., Seiler, S., Bell-Pedersen, D., Paietta, J., Plesofsky, N., Plamann, M., Goodrich-Tanrikulu, M., Schulte, U., Mannhaupt, G., Nargang, F. E., Radford, A., Selitrennikoff, C., Galagan, J. E., Dunlap, J. C., Loros, J. J., Catcheside, D., Inoue, H., Aramayo, R., Polymenis, M., Selker, E. U., Sachs, M. S., Marzluf, G. A., Paulsen, I., Davis, R., Ebbole, D. J., Zelter, A., Kalkman, E. R., O'Rourke, R., Bowring, F., Yeadon, J., Ishii, C., Suzuki, K., Sakai, W., Pratt, R. (2004). Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism. Microbiol. Mol. Biol. Rev. 68: 1-108 [Abstract] [Full Text]  
• BENARD, L. (2004). Inhibition of 5' to 3' mRNA degradation under stress conditions in Saccharomyces cerevisiae: from GCN4 to MET16. RNA 10: 458-468 [Abstract] [Full Text]  
• Brunson, L. E., Dixon, C., Kozubowski, L., Mathias, N. (2004). The Amino-terminal Portion of the F-box Protein Met30p Mediates Its Nuclear Import and Assimilation into an SCF Complex. J. Biol. Chem. 279: 6674-6682 [Abstract] [Full Text]  
• Jeon, T. J., Jeon, K. W. (2004). Gene switching in Amoeba proteus caused by endosymbiotic bacteria. J. Cell Sci. 117: 535-543 [Abstract] [Full Text]  
• Wheeler, G. L., Trotter, E. W., Dawes, I. W., Grant, C. M. (2003). Coupling of the Transcriptional Regulation of Glutathione Biosynthesis to the Availability of Glutathione and Methionine via the Met4 and Yap1 Transcription Factors. J. Biol. Chem. 278: 49920-49928 [Abstract] [Full Text]  
• Shor, B., Calaycay, J., Rushbrook, J., McLeod, M. (2003). Cpc2/RACK1 Is a Ribosome-associated Protein That Promotes Efficient Translation in Schizosaccharomyces pombe. J. Biol. Chem. 278: 49119-49128 [Abstract] [Full Text]  
• Sahara, T., Goda, T., Ohgiya, S. (2002). Comprehensive Expression Analysis of Time-dependent Genetic Responses in Yeast Cells to Low Temperature. J. Biol. Chem. 277: 50015-50021 [Abstract] [Full Text]  
• Ravina, C. G., Chang, C.-I., Tsakraklides, G. P., McDermott, J. P., Vega, J. M., Leustek, T., Gotor, C., Davies, J. P. (2002). The sac Mutants of Chlamydomonas reinhardtii Reveal Transcriptional and Posttranscriptional Control of Cysteine Biosynthesis. Plant Physiol. 130: 2076-2084 [Abstract] [Full Text]  
• Yang, Z., Pascon, R. C., Alspaugh, A., Cox, G. M., McCusker, J. H. (2002). Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. Microbiology 148: 2617-2625 [Abstract] [Full Text]  
• Hwang, B.-J., Yeom, H.-J., Kim, Y., Lee, H.-S. (2002). Corynebacterium glutamicum Utilizes both Transsulfuration and Direct Sulfhydrylation Pathways for Methionine Biosynthesis. J. Bacteriol. 184: 1277-1286 [Abstract] [Full Text]  
• Li, L., He, Z., Pandey, G. K., Tsuchiya, T., Luan, S. (2002). Functional Cloning and Characterization of a Plant Efflux Carrier for Multidrug and Heavy Metal Detoxification. J. Biol. Chem. 277: 5360-5368 [Abstract] [Full Text]  
• Auger, S., Yuen, W. H., Danchin, A., Martin-Verstraete, I. (2002). The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination. Microbiology 148: 507-518 [Abstract] [Full Text]  
• Baudouin-Cornu, P., Surdin-Kerjan, Y., Marliere, P., Thomas, D. (2001). Molecular Evolution of Protein Atomic Composition. Science 293: 297-300 [Abstract] [Full Text]  
• Natarajan, K., Meyer, M. R., Jackson, B. M., Slade, D., Roberts, C., Hinnebusch, A. G., Marton, M. J. (2001). Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast. Mol. Cell. Biol. 21: 4347-4368 [Abstract] [Full Text]  
• Diener, A. C., Gaxiola, R. A., Fink, G. R. (2001). Arabidopsis ALF5, a Multidrug Efflux Transporter Gene Family Member, Confers Resistance to Toxins. Plant Cell 13: 1625-1638 [Abstract] [Full Text]  
• Hsiung, Y. G., Chang, H.-C., Pellequer, J.-L., La Valle, R., Lanker, S., Wittenberg, C. (2001). F-Box Protein Grr1 Interacts with Phosphorylated Targets via the Cationic Surface of Its Leucine-Rich Repeat. Mol. Cell. Biol. 21: 2506-2520 [Abstract] [Full Text]  
• Kolko, M. M., Kapetanovich, L. A., Lawrence, J. G. (2001). Alternative Pathways for Siroheme Synthesis in Klebsiella aerogenes. J. Bacteriol. 183: 328-335 [Abstract] [Full Text]  
• Seiflein, T. A., Lawrence, J. G. (2001). Methionine-to-Cysteine Recycling in Klebsiella aerogenes. J. Bacteriol. 183: 336-346 [Abstract] [Full Text]  
• Smothers, D. B., Kozubowski, L., Dixon, C., Goebl, M. G., Mathias, N. (2000). The Abundance of Met30p Limits SCFMet30p Complex Activity and Is Regulated by Methionine Availability. Mol. Cell. Biol. 20: 7845-7852 [Abstract] [Full Text]  
• Cavalieri, D., Townsend, J. P., Hartl, D. L. (2000). Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis. Proc. Natl. Acad. Sci. USA 10.1073/pnas.210395297v1 [Abstract] [Full Text]  
• Hatzfeld, Y., Maruyama, A., Schmidt, A., Noji, M., Ishizawa, K., Saito, K. (2000). beta -Cyanoalanine Synthase Is a Mitochondrial Cysteine Synthase-Like Protein in Spinach and Arabidopsis. Plant Physiol. 123: 1163-1172 [Abstract] [Full Text]  
• Cherest, H., Thomas, D., Surdin-Kerjan, Y. (2000). Polyglutamylation of Folate Coenzymes Is Necessary for Methionine Biosynthesis and Maintenance of Intact Mitochondrial Genome in Saccharomyces cerevisiae. J. Biol. Chem. 275: 14056-14063 [Abstract] [Full Text]  
• Graham, D. E., Bock, C. L., Schalk-Hihi, C., Lu, Z. J., Markham, G. D. (2000). Identification of a Highly Diverged Class of S-Adenosylmethionine Synthetases in the Archaea. J. Biol. Chem. 275: 4055-4059 [Abstract] [Full Text]  
• BESSET, S., VINCOURT, J.-B., AMALRIC, F., GIRARD, J.-P. (2000). Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. FASEB J. 14: 345-354 [Abstract] [Full Text]  
• van de Kamp, M., Pizzinini, E., Vos, A., van der Lende, T. R., Schuurs, T. A., Newbert, R. W., Turner, G., Konings, W. N., Driessen, A. J. M. (1999). Sulfate Transport in Penicillium chrysogenum: Cloning and Characterization of the sutA and sutB Genes. J. Bacteriol. 181: 7228-7234 [Abstract] [Full Text]  
• de Nadal, E., Calero, F., Ramos, J., Ariño, J. (1999). Biochemical and Genetic Analyses of the Role of Yeast Casein Kinase 2 in Salt Tolerance. J. Bacteriol. 181: 6456-6462 [Abstract] [Full Text]  
• Rouillon, A., Surdin-Kerjan, Y., Thomas, D. (1999). Transport of Sulfonium Compounds. CHARACTERIZATION OF THE S-ADENOSYLMETHIONINE AND S-METHYLMETHIONINE PERMEASES FROM THE YEAST SACCHAROMYCES CEREVISIAE. J. Biol. Chem. 274: 28096-28105 [Abstract] [Full Text]  
• Vermeij, P., Kertesz, M. A. (1999). Pathways of Assimilative Sulfur Metabolism in Pseudomonas putida. J. Bacteriol. 181: 5833-5837 [Abstract] [Full Text]  
• Ravanel, S., Gakiere, B., Job, D., Douce, R. (1998). The specific features of methionine biosynthesis and metabolism in plants. Proc. Natl. Acad. Sci. USA 95: 7805-7812 [Abstract] [Full Text]  
• Thomas, D., Becker, A., Surdin-Kerjan, Y. (2000). Reverse Methionine Biosynthesis from S-Adenosylmethionine in Eukaryotic Cells. J. Biol. Chem. 275: 40718-40724 [Abstract] [Full Text]  
• Cavalieri, D., Townsend, J. P., Hartl, D. L. (2000). Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis. Proc. Natl. Acad. Sci. USA 97: 12369-12374 [Abstract] [Full Text]