This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cornelis, G. R.
Right arrow Articles by Stainier, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cornelis, G. R.
Right arrow Articles by Stainier, I.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, December 1998, p. 1315-1352, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Virulence Plasmid of Yersinia, an Antihost Genome

Guy R. Cornelis,* Anne Boland, Aoife P. Boyd, Cecile Geuijen, Maite Iriarte, Cécile Neyt, Marie-Paule Sory, and Isabelle Stainier

Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Université Catholique de Louvain, B-1200 Brussels, Belgium

The 70-kb virulence plasmid enables Yersinia spp. (Yersinia pestis, Y. pseudotuberculosis, and Y. enterocolitica) to survive and multiply in the lymphoid tissues of their host. It encodes the Yop virulon, an integrated system allowing extracellular bacteria to disarm the cells involved in the immune response, to disrupt their communications, or even to induce their apoptosis by the injection of bacterial effector proteins. This system consists of the Yop proteins and their dedicated type III secretion apparatus, called Ysc. The Ysc apparatus is composed of some 25 proteins including a secretin. Most of the Yops fall into two groups. Some of them are the intracellular effectors (YopE, YopH, YpkA/YopO, YopP/YopJ, YopM, and YopT), while the others (YopB, YopD, and LcrV) form the translocation apparatus that is deployed at the bacterial surface to deliver the effectors into the eukaryotic cells, across their plasma membrane. Yop secretion is triggered by contact with eukaryotic cells and controlled by proteins of the virulon including YopN, TyeA, and LcrG, which are thought to form a plug complex closing the bacterial secretion channel. The proper operation of the system also requires small individual chaperones, called the Syc proteins, in the bacterial cytosol. Transcription of the genes is controlled both by temperature and by the activity of the secretion apparatus. The virulence plasmid of Y. enterocolitica and Y. pseudotuberculosis also encodes the adhesin YadA. The virulence plasmid contains some evolutionary remnants including, in Y. enterocolitica, an operon encoding resistance to arsenic compounds.

* Corresponding author. Mailing address: Microbial Pathogenesis Unit, Université de Louvain, Ave. Hippocrate 74, UCL 74.49, B-1200 Brussels, Belgium. Phone: 32 2 764 74 49. Fax: 32 2 764 74 98. E-mail: cornelis{at}mipa.ucl.ac.be.

Microbiology and Molecular Biology Reviews, December 1998, p. 1315-1352, Vol. 62, No. 4
1092-2172/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Bergsbaken, T., Cookson, B. T. (2009). Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation. J. Leukoc. Biol. 86: 1153-1158 [Abstract] [Full Text]  
  • Dessein, R, Gironella, M, Vignal, C, Peyrin-Biroulet, L, Sokol, H, Secher, T, Lacas-Gervais, S, Gratadoux, J-J, Lafont, F, Dagorn, J-C, Ryffel, B, Akira, S, Langella, P, Nunez, G, Sirard, J-C, Iovanna, J, Simonet, M, Chamaillard, M (2009). Toll-like receptor 2 is critical for induction of Reg3{beta} expression and intestinal clearance of Yersinia pseudotuberculosis. Gut 58: 771-776 [Abstract] [Full Text]  
  • Schmid, A., Neumayer, W., Trulzsch, K., Israel, L., Imhof, A., Roessle, M., Sauer, G., Richter, S., Lauw, S., Eylert, E., Eisenreich, W., Heesemann, J., Wilharm, G. (2009). Cross-talk between Type Three Secretion System and Metabolism in Yersinia. J. Biol. Chem. 284: 12165-12177 [Abstract] [Full Text]  
  • Walker, K. A., Miller, V. L. (2009). Synchronous Gene Expression of the Yersinia enterocolitica Ysa Type III Secretion System and Its Effectors. J. Bacteriol. 191: 1816-1826 [Abstract] [Full Text]  
  • Sebbane, F., Jarrett, C., Gardner, D., Long, D., Hinnebusch, B. J. (2009). The Yersinia pestis caf1M1A1 Fimbrial Capsule Operon Promotes Transmission by Flea Bite in a Mouse Model of Bubonic Plague. Infect. Immun. 77: 1222-1229 [Abstract] [Full Text]  
  • Felek, S., Krukonis, E. S. (2009). The Yersinia pestis Ail Protein Mediates Binding and Yop Delivery to Host Cells Required for Plague Virulence. Infect. Immun. 77: 825-836 [Abstract] [Full Text]  
  • Riordan, K. E., Sorg, J. A., Berube, B. J., Schneewind, O. (2008). Impassable YscP Substrates and Their Impact on the Yersinia enterocolitica Type III Secretion Pathway. J. Bacteriol. 190: 6204-6216 [Abstract] [Full Text]  
  • Lilo, S., Zheng, Y., Bliska, J. B. (2008). Caspase-1 Activation in Macrophages Infected with Yersinia pestis KIM Requires the Type III Secretion System Effector YopJ. Infect. Immun. 76: 3911-3923 [Abstract] [Full Text]  
  • Turner, J. K., McAllister, M. M., Xu, J. L., Tapping, R. I. (2008). The Resistance of BALB/cJ Mice to Yersinia pestis Maps to the Major Histocompatibility Complex of Chromosome 17. Infect. Immun. 76: 4092-4099 [Abstract] [Full Text]  
  • Zhang, Y., Murtha, J., Roberts, M. A., Siegel, R. M., Bliska, J. B. (2008). Type III Secretion Decreases Bacterial and Host Survival following Phagocytosis of Yersinia pseudotuberculosis by Macrophages. Infect. Immun. 76: 4299-4310 [Abstract] [Full Text]  
  • Kim, T.-J., Young, B. M., Young, G. M. (2008). Effect of Flagellar Mutations on Yersinia enterocolitica Biofilm Formation. Appl. Environ. Microbiol. 74: 5466-5474 [Abstract] [Full Text]  
  • Spinner, J. L., Cundiff, J. A., Kobayashi, S. D. (2008). Yersinia pestis Type III Secretion System-Dependent Inhibition of Human Polymorphonuclear Leukocyte Function. Infect. Immun. 76: 3754-3760 [Abstract] [Full Text]  
  • Wood, S. E., Jin, J., Lloyd, S. A. (2008). YscP and YscU Switch the Substrate Specificity of the Yersinia Type III Secretion System by Regulating Export of the Inner Rod Protein YscI. J. Bacteriol. 190: 4252-4262 [Abstract] [Full Text]  
  • Felek, S., Lawrenz, M. B., Krukonis, E. S. (2008). The Yersinia pestis autotransporter YapC mediates host cell binding, autoaggregation and biofilm formation. Microbiology 154: 1802-1812 [Abstract] [Full Text]  
  • Sha, J., Agar, S. L., Baze, W. B., Olano, J. P., Fadl, A. A., Erova, T. E., Wang, S., Foltz, S. M., Suarez, G., Motin, V. L., Chauhan, S., Klimpel, G. R., Peterson, J. W., Chopra, A. K. (2008). Braun Lipoprotein (Lpp) Contributes to Virulence of Yersiniae: Potential Role of Lpp in Inducing Bubonic and Pneumonic Plague. Infect. Immun. 76: 1390-1409 [Abstract] [Full Text]  
  • Fennelly, N. K., Sisti, F., Higgins, S. C., Ross, P. J., van der Heide, H., Mooi, F. R., Boyd, A., Mills, K. H. G. (2008). Bordetella pertussis Expresses a Functional Type III Secretion System That Subverts Protective Innate and Adaptive Immune Responses. Infect. Immun. 76: 1257-1266 [Abstract] [Full Text]  
  • Broms, J. E., Francis, M. S., Forsberg, A. (2007). Diminished LcrV Secretion Attenuates Yersinia pseudotuberculosis Virulence. J. Bacteriol. 189: 8417-8429 [Abstract] [Full Text]  
  • Falker, S., Schilling, J., Schmidt, M. A., Heusipp, G. (2007). Overproduction of DNA Adenine Methyltransferase Alters Motility, Invasion, and the Lipopolysaccharide O-Antigen Composition of Yersinia enterocolitica. Infect. Immun. 75: 4990-4997 [Abstract] [Full Text]  
  • Carlsson, K. E., Liu, J., Edqvist, P. J., Francis, M. S. (2007). Influence of the Cpx Extracytoplasmic-Stress-Responsive Pathway on Yersinia sp.-Eukaryotic Cell Contact. Infect. Immun. 75: 4386-4399 [Abstract] [Full Text]  
  • Brzostek, K., Brzostkowska, M., Bukowska, I., Karwicka, E., Raczkowska, A. (2007). OmpR negatively regulates expression of invasin in Yersinia enterocolitica. Microbiology 153: 2416-2425 [Abstract] [Full Text]  
  • Carlsson, K. E., Liu, J., Edqvist, P. J., Francis, M. S. (2007). Extracytoplasmic-Stress-Responsive Pathways Modulate Type III Secretion in Yersinia pseudotuberculosis. Infect. Immun. 75: 3913-3924 [Abstract] [Full Text]  
  • Oyarzabal, O. A., Rad, R., Backert, S. (2007). Conjugative Transfer of Chromosomally Encoded Antibiotic Resistance from Helicobacter pylori to Campylobacter jejuni. J. Clin. Microbiol. 45: 402-408 [Abstract] [Full Text]  
  • Trasak, C., Zenner, G., Vogel, A., Yuksekdag, G., Rost, R., Haase, I., Fischer, M., Israel, L., Imhof, A., Linder, S., Schleicher, M., Aepfelbacher, M. (2007). Yersinia Protein Kinase YopO Is Activated by A Novel G-actin Binding Process. J. Biol. Chem. 282: 2268-2277 [Abstract] [Full Text]  
  • Falcao, J. P., Falcao, D. P., Pitondo-Silva, A., Malaspina, A. C., Brocchi, M. (2006). Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil.. J Med Microbiol 55: 1539-1548 [Abstract] [Full Text]  
  • Liu, F., Chen, H., Galvan, E. M., Lasaro, M. A., Schifferli, D. M. (2006). Effects of Psa and F1 on the Adhesive and Invasive Interactions of Yersinia pestis with Human Respiratory Tract Epithelial Cells.. Infect. Immun. 74: 5636-5644 [Abstract] [Full Text]  
  • Falker, S., Schmidt, M. A., Heusipp, G. (2006). Altered Ca2+ Regulation of Yop Secretion in Yersinia enterocolitica after DNA Adenine Methyltransferase Overproduction Is Mediated by Clp-Dependent Degradation of LcrG.. J. Bacteriol. 188: 7072-7081 [Abstract] [Full Text]  
  • Lemaitre, N., Sebbane, F., Long, D., Joseph Hinnebusch, B. (2006). Yersinia pestis YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for Virulence in a Rat Model of Bubonic Plague. Infect. Immun. 74: 5126-5131 [Abstract] [Full Text]  
  • Huang, X.-Z., Nikolich, M. P., Lindler, L. E. (2006). Current trends in plague research: from genomics to virulence.. Clin Med Res 4: 189-199 [Abstract] [Full Text]  
  • Sebbane, F., Lemaitre, N., Sturdevant, D. E., Rebeil, R., Virtaneva, K., Porcella, S. F., Hinnebusch, B. J. (2006). Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague. Proc. Natl. Acad. Sci. USA 103: 11766-11771 [Abstract] [Full Text]  
  • Buhler, O. T., Wiedig, C. A., Schmid, Y., Grassl, G. A., Bohn, E., Autenrieth, I. B. (2006). The Yersinia enterocolitica Invasin Protein Promotes Major Histocompatibility Complex Class I- and Class II-Restricted T-Cell Responses. Infect. Immun. 74: 4322-4329 [Abstract] [Full Text]  
  • Meyer, D., Cunnac, S., Gueneron, M., Declercq, C., Van Gijsegem, F., Lauber, E., Boucher, C., Arlat, M. (2006). PopF1 and PopF2, Two Proteins Secreted by the Type III Protein Secretion System of Ralstonia solanacearum, Are Translocators Belonging to the HrpF/NopX Family. J. Bacteriol. 188: 4903-4917 [Abstract] [Full Text]  
  • Barnes, P. D., Bergman, M. A., Mecsas, J., Isberg, R. R. (2006). Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. JEM 203: 1591-1601 [Abstract] [Full Text]  
  • Ebanks, R. O., Knickle, L. C., Goguen, M., Boyd, J. M., Pinto, D. M., Reith, M., Ross, N. W. (2006). Expression of and secretion through the Aeromonas salmonicida type III secretion system.. Microbiology 152: 1275-1286 [Abstract] [Full Text]  
  • van Erp, K., Dach, K., Koch, I., Heesemann, J., Hoffmann, R. (2006). Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica. Physiol. Genomics 25: 75-84 [Abstract] [Full Text]  
  • Andersson, H., Hartmanova, B., KuoLee, R., Ryden, P., Conlan, W., Chen, W., Sjostedt, A. (2006). Transcriptional profiling of host responses in mouse lungs following aerosol infection with type A Francisella tularensis.. J Med Microbiol 55: 263-271 [Abstract] [Full Text]  
  • Li, Y., Martinez, G., Gottschalk, M., Lacouture, S., Willson, P., Dubreuil, J. D., Jacques, M., Harel, J. (2006). Identification of a Surface Protein of Streptococcus suis and Evaluation of Its Immunogenic and Protective Capacity in Pigs. Infect. Immun. 74: 305-312 [Abstract] [Full Text]  
  • Sorg, J. A., Miller, N. C., Marketon, M. M., Schneewind, O. (2005). Rejection of Impassable Substrates by Yersinia Type III Secretion Machines. J. Bacteriol. 187: 7090-7102 [Abstract] [Full Text]  
  • Tennant, S. M., Skinner, N. A., Joe, A., Robins-Browne, R. M. (2005). Homologues of Insecticidal Toxin Complex Genes in Yersinia enterocolitica Biotype 1A and Their Contribution to Virulence. Infect. Immun. 73: 6860-6867 [Abstract] [Full Text]  
  • Marketon, M. M., DePaolo, R. W., DeBord, K. L., Jabri, B., Schneewind, O. (2005). Plague Bacteria Target Immune Cells During Infection. Science 309: 1739-1741 [Abstract] [Full Text]  
  • Warren, S. M., Young, G. M. (2005). An Amino-Terminal Secretion Signal Is Required for YplA Export by the Ysa, Ysc, and Flagellar Type III Secretion Systems of Yersinia enterocolitica Biovar 1B. J. Bacteriol. 187: 6075-6083 [Abstract] [Full Text]  
  • Zhang, Y., Ting, A. T., Marcu, K. B., Bliska, J. B. (2005). Inhibition of MAPK and NF-{kappa}B Pathways Is Necessary for Rapid Apoptosis in Macrophages Infected with Yersinia. J. Immunol. 174: 7939-7949 [Abstract] [Full Text]  
  • Bleves, S., Soscia, C., Nogueira-Orlandi, P., Lazdunski, A., Filloux, A. (2005). Quorum Sensing Negatively Controls Type III Secretion Regulon Expression in Pseudomonas aeruginosa PAO1. J. Bacteriol. 187: 3898-3902 [Abstract] [Full Text]  
  • Garmendia, J., Frankel, G., Crepin, V. F. (2005). Enteropathogenic and Enterohemorrhagic Escherichia coli Infections: Translocation, Translocation, Translocation. Infect. Immun. 73: 2573-2585 [Full Text]  
  • Sebbane, F., Gardner, D., Long, D., Gowen, B. B., Hinnebusch, B. J. (2005). Kinetics of Disease Progression and Host Response in a Rat Model of Bubonic Plague. Am. J. Pathol. 166: 1427-1439 [Abstract] [Full Text]  
  • Deng, W., Li, Y., Hardwidge, P. R., Frey, E. A., Pfuetzner, R. A., Lee, S., Gruenheid, S., Strynakda, N. C. J., Puente, J. L., Finlay, B. B. (2005). Regulation of Type III Secretion Hierarchy of Translocators and Effectors in Attaching and Effacing Bacterial Pathogens. Infect. Immun. 73: 2135-2146 [Abstract] [Full Text]  
  • Bruckner, S., Rhamouni, S., Tautz, L., Denault, J.-B., Alonso, A., Becattini, B., Salvesen, G. S., Mustelin, T. (2005). Yersinia Phosphatase Induces Mitochondrially Dependent Apoptosis of T Cells. J. Biol. Chem. 280: 10388-10394 [Abstract] [Full Text]  
  • Sato, K., Sakai, E., Veith, P. D., Shoji, M., Kikuchi, Y., Yukitake, H., Ohara, N., Naito, M., Okamoto, K., Reynolds, E. C., Nakayama, K. (2005). Identification of a New Membrane-associated Protein That Influences Transport/Maturation of Gingipains and Adhesins of Porphyromonas gingivalis. J. Biol. Chem. 280: 8668-8677 [Abstract] [Full Text]  
  • Tautz, L., Bruckner, S., Sareth, S., Alonso, A., Bogetz, J., Bottini, N., Pellecchia, M., Mustelin, T. (2005). Inhibition of Yersinia Tyrosine Phosphatase by Furanyl Salicylate Compounds. J. Biol. Chem. 280: 9400-9408 [Abstract] [Full Text]  
  • Philipovskiy, A. V., Cowan, C., Wulff-Strobel, C. R., Burnett, S. H., Kerschen, E. J., Cohen, D. A., Kaplan, A. M., Straley, S. C. (2005). Antibody against V Antigen Prevents Yop-Dependent Growth of Yersinia pestis. Infect. Immun. 73: 1532-1542 [Abstract] [Full Text]  
  • Gall, T. L., Mavris, M., Martino, M. C., Bernardini, M. L., Denamur, E., Parsot, C. (2005). Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri. Microbiology 151: 951-962 [Abstract] [Full Text]  
  • Gerke, C., Falkow, S., Chien, Y.-h. (2005). The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation. JEM 201: 361-371 [Abstract] [Full Text]  
  • Wagner, D., Maser, J., Lai, B., Cai, Z., Barry, C. E. III, Honer zu Bentrup, K., Russell, D. G., Bermudez, L. E. (2005). Elemental Analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-Containing Phagosomes Indicates Pathogen-Induced Microenvironments within the Host Cell's Endosomal System. J. Immunol. 174: 1491-1500 [Abstract] [Full Text]  
  • Ramamurthi, K. S., Schneewind, O. (2005). A Synonymous Mutation in Yersinia enterocolitica yopE Affects the Function of the YopE Type III Secretion Signal. J. Bacteriol. 187: 707-715 [Abstract] [Full Text]  
  • Saikh, K. U., Kissner, T. L., Sultana, A., Ruthel, G., Ulrich, R. G. (2004). Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells. J. Immunol. 173: 7426-7434 [Abstract] [Full Text]  
  • Ghosh, P. (2004). Process of Protein Transport by the Type III Secretion System. Microbiol. Mol. Biol. Rev. 68: 771-795 [Abstract] [Full Text]  
  • Schmid, Y., Grassl, G. A., Buhler, O. T., Skurnik, M., Autenrieth, I. B., Bohn, E. (2004). Yersinia enterocolitica Adhesin A Induces Production of Interleukin-8 in Epithelial Cells. Infect. Immun. 72: 6780-6789 [Abstract] [Full Text]  
  • Huang, X.-Z., Lindler, L. E. (2004). The pH 6 Antigen Is an Antiphagocytic Factor Produced by Yersinia pestis Independent of Yersinia Outer Proteins and Capsule Antigen. Infect. Immun. 72: 7212-7219 [Abstract] [Full Text]  
  • Goss, J. W., Sorg, J. A., Ramamurthi, K. S., Ton-That, H., Schneewind, O. (2004). The Secretion Signal of YopN, a Regulatory Protein of the Yersinia enterocolitica Type III Secretion Pathway. J. Bacteriol. 186: 6320-6324 [Abstract] [Full Text]  
  • Ruckdeschel, K., Pfaffinger, G., Haase, R., Sing, A., Weighardt, H., Hacker, G., Holzmann, B., Heesemann, J. (2004). Signaling of Apoptosis through TLRs Critically Involves Toll/IL-1 Receptor Domain-Containing Adapter Inducing IFN-{beta}, but Not MyD88, in Bacteria-Infected Murine Macrophages. J. Immunol. 173: 3320-3328 [Abstract] [Full Text]  
  • Goure, J., Pastor, A., Faudry, E., Chabert, J., Dessen, A., Attree, I. (2004). The V Antigen of Pseudomonas aeruginosa Is Required for Assembly of the Functional PopB/PopD Translocation Pore in Host Cell Membranes. Infect. Immun. 72: 4741-4750 [Abstract] [Full Text]  
  • Walker, K. A., Miller, V. L. (2004). Regulation of the Ysa Type III Secretion System of Yersinia enterocolitica by YsaE/SycB and YsrS/YsrR. J. Bacteriol. 186: 4056-4066 [Abstract] [Full Text]  
  • Olsson, J., Edqvist, P. J., Broms, J. E., Forsberg, A., Wolf-Watz, H., Francis, M. S. (2004). The YopD Translocator of Yersinia pseudotuberculosis Is a Multifunctional Protein Comprised of Discrete Domains. J. Bacteriol. 186: 4110-4123 [Abstract] [Full Text]  
  • Schotte, P., Denecker, G., Van Den Broeke, A., Vandenabeele, P., Cornelis, G. R., Beyaert, R. (2004). Targeting Rac1 by the Yersinia Effector Protein YopE Inhibits Caspase-1-mediated Maturation and Release of Interleukin-1{beta}. J. Biol. Chem. 279: 25134-25142 [Abstract] [Full Text]  
  • Konkel, M. E., Klena, J. D., Rivera-Amill, V., Monteville, M. R., Biswas, D., Raphael, B., Mickelson, J. (2004). Secretion of Virulence Proteins from Campylobacter jejuni Is Dependent on a Functional Flagellar Export Apparatus. J. Bacteriol. 186: 3296-3303 [Abstract] [Full Text]  
  • Hoffmann, C., Pop, M., Leemhuis, J., Schirmer, J., Aktories, K., Schmidt, G. (2004). The Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor (CNFY) Selectively Activates RhoA. J. Biol. Chem. 279: 16026-16032 [Abstract] [Full Text]  
  • Anisimov, A. P., Lindler, L. E., Pier, G. B. (2004). Intraspecific Diversity of Yersinia pestis. Clin. Microbiol. Rev. 17: 434-464 [Abstract] [Full Text]  
  • Alonso, A., Bottini, N., Bruckner, S., Rahmouni, S., Williams, S., Schoenberger, S. P., Mustelin, T. (2004). Lck Dephosphorylation at Tyr-394 and Inhibition of T Cell Antigen Receptor Signaling by Yersinia Phosphatase YopH. J. Biol. Chem. 279: 4922-4928 [Abstract] [Full Text]  
  • Flashner, Y., Mamroud, E., Tidhar, A., Ber, R., Aftalion, M., Gur, D., Lazar, S., Zvi, A., Bino, T., Ariel, N., Velan, B., Shafferman, A., Cohen, S. (2004). Generation of Yersinia pestis Attenuated Strains by Signature-Tagged Mutagenesis in Search of Novel Vaccine Candidates. Infect. Immun. 72: 908-915 [Abstract] [Full Text]  
  • Schmidt, H., Hensel, M. (2004). Pathogenicity Islands in Bacterial Pathogenesis. Clin. Microbiol. Rev. 17: 14-56 [Abstract] [Full Text]  
  • Fernandez, L., Lopez, J. R., Secades, P., Menendez, A., Marquez, I., Guijarro, J. A. (2003). In Vitro and In Vivo Studies of the Yrp1 Protease from Yersinia ruckeri and Its Role in Protective Immunity against Enteric Red Mouth Disease of Salmonids. Appl. Environ. Microbiol. 69: 7328-7335 [Abstract] [Full Text]  
  • Ashrafian, H. (2003). Hepcidin: the Missing Link between Hemochromatosis and Infections. Infect. Immun. 71: 6693-6700 [Full Text]  
  • Liang, F., Huang, Z., Lee, S.-Y., Liang, J., Ivanov, M. I., Alonso, A., Bliska, J. B., Lawrence, D. S., Mustelin, T., Zhang, Z.-Y. (2003). Aurintricarboxylic Acid Blocks in Vitro and in Vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague. J. Biol. Chem. 278: 41734-41741 [Abstract] [Full Text]  
  • Tsoktouridis, G., Merz, C. A., Manning, S. P., Giovagnoli-Kurtz, R., Williams, L. E., Mujer, C. V., Hagius, S., Elzer, P., Redkar, R. J., Patra, G., DelVecchio, V. G. (2003). Molecular Characterization of Brucella abortus Chromosome II Recombination. J. Bacteriol. 185: 6130-6136 [Abstract] [Full Text]  
  • Haase, R., Kirschning, C. J., Sing, A., Schrottner, P., Fukase, K., Kusumoto, S., Wagner, H., Heesemann, J., Ruckdeschel, K. (2003). A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages. J. Immunol. 171: 4294-4303 [Abstract] [Full Text]  
  • Pujol, C., Bliska, J. B. (2003). The Ability To Replicate in Macrophages Is Conserved between Yersinia pestis and Yersinia pseudotuberculosis. Infect. Immun. 71: 5892-5899 [Abstract] [Full Text]  
  • Broms, J. E., Forslund, A.-L., Forsberg, A., Francis, M. S. (2003). Dissection of homologous translocon operons reveals a distinct role for YopD in type III secretion by Yersinia pseudotuberculosis. Microbiology 149: 2615-2626 [Abstract] [Full Text]  
  • Aepfelbacher, M., Trasak, C., Wilharm, G., Wiedemann, A., Trulzsch, K., Krauss, K., Gierschik, P., Heesemann, J. (2003). Characterization of YopT Effects on Rho GTPases in Yersinia enterocolitica-infected Cells. J. Biol. Chem. 278: 33217-33223 [Abstract] [Full Text]  
  • Sun, J.-P., Wu, L., Fedorov, A. A., Almo, S. C., Zhang, Z.-Y. (2003). Crystal Structure of the Yersinia Protein-tyrosine Phosphatase YopH Complexed with a Specific Small Molecule Inhibitor. J. Biol. Chem. 278: 33392-33399 [Abstract] [Full Text]  
  • Logsdon, L. K., Mecsas, J. (2003). Requirement of the Yersinia pseudotuberculosis Effectors YopH and YopE in Colonization and Persistence in Intestinal and Lymph Tissues. Infect. Immun. 71: 4595-4607 [Abstract] [Full Text]  
  • Sorg, I., Hoffmann, C., Dumbach, J., Aktories, K., Schmidt, G. (2003). The C Terminus of YopT Is Crucial for Activity and the N Terminus Is Crucial for Substrate Binding. Infect. Immun. 71: 4623-4632 [Abstract] [Full Text]  
  • Brubaker, R. R. (2003). Interleukin-10 and Inhibition of Innate Immunity to Yersiniae: Roles of Yops and LcrV (V Antigen). Infect. Immun. 71: 3673-3681 [Full Text]  
  • Roggenkamp, A., Ackermann, N., Jacobi, C. A., Truelzsch, K., Hoffmann, H., Heesemann, J. (2003). Molecular Analysis of Transport and Oligomerization of the Yersinia enterocolitica Adhesin YadA. J. Bacteriol. 185: 3735-3744 [Abstract] [Full Text]  
  • DeBord, K. L., Galanopoulos, N. S., Schneewind, O. (2003). The ttsA Gene Is Required for Low-Calcium-Induced Type III Secretion of Yop Proteins and Virulence of Yersinia enterocolitica W22703. J. Bacteriol. 185: 3499-3507 [Abstract] [Full Text]  
  • Russmann, H., Gerdemann, U., Igwe, E. I., Panthel, K., Heesemann, J., Garbom, S., Wolf-Watz, H., Geginat, G. (2003). Attenuated Yersinia pseudotuberculosis Carrier Vaccine for Simultaneous Antigen-Specific CD4 and CD8 T-Cell Induction. Infect. Immun. 71: 3463-3472 [Abstract] [Full Text]  
  • McDonald, C., Vacratsis, P. O., Bliska, J. B., Dixon, J. E. (2003). The Yersinia Virulence Factor YopM Forms a Novel Protein Complex with Two Cellular Kinases. J. Biol. Chem. 278: 18514-18523 [Abstract] [Full Text]  
  • Miyata, S., Casey, M., Frank, D. W., Ausubel, F. M., Drenkard, E. (2003). Use of the Galleria mellonella Caterpillar as a Model Host To Study the Role of the Type III Secretion System in Pseudomonas aeruginosa Pathogenesis. Infect. Immun. 71: 2404-2413 [Abstract] [Full Text]  
  • Feodorova, V. A., Samelija, J. G., Devdariani, Z. L. (2003). Heat-stable serogroup-specific proteins of Yersinia pseudotuberculosis. J Med Microbiol 52: 389-395 [Abstract] [Full Text]  
  • Fredriksson-Ahomaa, M., Korkeala, H. (2003). Low Occurrence of Pathogenic Yersinia enterocolitica in Clinical, Food, and Environmental Samples: a Methodological Problem. Clin. Microbiol. Rev. 16: 220-229 [Abstract] [Full Text]  
  • Bengoechea, J. A., Brandenburg, K., Arraiza, M. D., Seydel, U., Skurnik, M., Moriyon, I. (2003). Pathogenic Yersinia enterocolitica Strains Increase the Outer Membrane Permeability in Response to Environmental Stimuli by Modulating Lipopolysaccharide Fluidity and Lipid A Structure. Infect. Immun. 71: 2014-2021 [Abstract] [Full Text]  
  • Zhang, Y., Bliska, J. B. (2003). Role of Toll-Like Receptor Signaling in the Apoptotic Response of Macrophages to Yersinia Infection. Infect. Immun. 71: 1513-1519 [Abstract] [Full Text]  
  • Hauf, N., Chakraborty, T. (2003). Suppression of NF-{kappa}B Activation and Proinflammatory Cytokine Expression by Shiga Toxin-Producing Escherichia coli. J. Immunol. 170: 2074-2082 [Abstract] [Full Text]  
  • Shao, F., Vacratsis, P. O., Bao, Z., Bowers, K. E., Fierke, C. A., Dixon, J. E. (2003). Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases. Proc. Natl. Acad. Sci. USA 100: 904-909 [Abstract] [Full Text]  
  • Cambronne, E. D., Schneewind, O. (2002). Yersinia enterocolitica Type III Secretion: yscM1 and yscM2 Regulate yop Gene Expression by a Posttranscriptional Mechanism That Targets the 5' Untranslated Region of yop mRNA. J. Bacteriol. 184: 5880-5893 [Abstract] [Full Text]  
  • Kopp, E., Medzhitov, R. (2002). A Plague on Host Defense. JEM 196: 1009-1012 [Full Text]  
  • Sing, A., Rost, D., Tvardovskaia, N., Roggenkamp, A., Wiedemann, A., Kirschning, C. J., Aepfelbacher, M., Heesemann, J. (2002). Yersinia V-Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10-mediated Immunosuppression. JEM 196: 1017-1024 [Abstract] [Full Text]  
  • Young, B. M., Young, G. M. (2002). Evidence for Targeting of Yop Effectors by the Chromosomally Encoded Ysa Type III Secretion System of Yersinia enterocolitica. J. Bacteriol. 184: 5563-5571 [Abstract] [Full Text]  
  • Ruckdeschel, K., Richter, K. (2002). Lipopolysaccharide Desensitization of Macrophages Provides Protection against Yersinia enterocolitica-Induced Apoptosis. Infect. Immun. 70: 5259-5264 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»