This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sullivan, C. S.
Right arrow Articles by Pipas, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sullivan, C. S.
Right arrow Articles by Pipas, J. M.

 Previous Article  |  Next Article 

Microbiology and Molecular Biology Reviews, June 2002, p. 179-202, Vol. 66, No. 2
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.2.179-202.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and Tumorigenesis

Christopher S. Sullivan and James M. Pipas*

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle. Deciphering how a single protein can perform such numerous and diverse functions has remained elusive. Recently it was established that the SV40 T antigens, including large T antigen, are molecular chaperones, each with a functioning DnaJ domain. The molecular chaperones were originally identified as bacterial genes essential for bacteriophage growth and have since been shown to be conserved in eukaryotes, participating in an array of both viral and cellular processes. This review discusses the mechanisms of DnaJ/Hsc70 interactions and how they are used by T antigen to control viral replication and tumorigenesis. The use of the DnaJ/Hsc70 system by SV40 and other viruses suggests an important role for these molecular chaperones in the regulation of the mammalian cell cycle and sheds light on the enigmatic SV40 T antigen—a most amazing molecule.

* Corresponding author. Mailing address: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260. Phone: (412) 624-4691. Fax: (412) 624-9311. E-mail: pipas{at}pitt.edu.

Microbiology and Molecular Biology Reviews, June 2002, p. 179-202, Vol. 66, No. 2
1092-2172/02/$04.00+0     DOI: 10.1128/MMBR.66.2.179-202.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fluck, M. M., Schaffhausen, B. S. (2009). Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen. Microbiol. Mol. Biol. Rev. 73: 542-563 [Abstract] [Full Text]  
  • Ahuja, D., Rathi, A. V., Greer, A. E., Chen, X. S., Pipas, J. M. (2009). A Structure-Guided Mutational Analysis of Simian Virus 40 Large T Antigen: Identification of Surface Residues Required for Viral Replication and Transformation. J. Virol. 83: 8781-8788 [Abstract] [Full Text]  
  • Imamura, Y., Fujigaki, Y., Oomori, Y., Usui, S., Wang, P.-L. (2009). Cooperation of Salivary Protein Histatin 3 with Heat Shock Cognate Protein 70 Relative to the G1/S Transition in Human Gingival Fibroblasts. J. Biol. Chem. 284: 14316-14325 [Abstract] [Full Text]  
  • Umbach, J. L., Cullen, B. R. (2009). The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev. 23: 1151-1164 [Abstract] [Full Text]  
  • Wang, W., Simmons, D. T. (2009). Simian Virus 40 Large T Antigen Can Specifically Unwind the Central Palindrome at the Origin of DNA Replication. J. Virol. 83: 3312-3322 [Abstract] [Full Text]  
  • Li, P. P., Itoh, N., Watanabe, M., Shi, Y., Liu, P., Yang, H.-J., Kasamatsu, H. (2009). Association of Simian Virus 40 Vp1 with 70-Kilodalton Heat Shock Proteins and Viral Tumor Antigens. J. Virol. 83: 37-46 [Abstract] [Full Text]  
  • Lace, M. J., Anson, J. R., Thomas, G. S., Turek, L. P., Haugen, T. H. (2008). The E8{wedge}E2 Gene Product of Human Papillomavirus Type 16 Represses Early Transcription and Replication but Is Dispensable for Viral Plasmid Persistence in Keratinocytes. J. Virol. 82: 10841-10853 [Abstract] [Full Text]  
  • Kumar, A., Joo, W. S., Meinke, G., Moine, S., Naumova, E. N., Bullock, P. A. (2008). Evidence for a Structural Relationship between BRCT Domains and the Helicase Domains of the Replication Initiators Encoded by the Polyomaviridae and Papillomaviridae Families of DNA Tumor Viruses. J. Virol. 82: 8849-8862 [Abstract] [Full Text]  
  • Greenleaf, W. B., Shen, J., Gai, D., Chen, X. S. (2008). Systematic Study of the Functions for the Residues around the Nucleotide Pocket in Simian Virus 40 AAA+ Hexameric Helicase. J. Virol. 82: 6017-6023 [Abstract] [Full Text]  
  • Zhao, X., Madden-Fuentes, R. J., Lou, B. X., Pipas, J. M., Gerhardt, J., Rigell, C. J., Fanning, E. (2008). Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells. J. Virol. 82: 5316-5328 [Abstract] [Full Text]  
  • Yu, Y., Alwine, J. C. (2008). Interaction between Simian Virus 40 Large T Antigen and Insulin Receptor Substrate 1 Is Disrupted by the K1 Mutation, Resulting in the Loss of Large T Antigen-Mediated Phosphorylation of Akt. J. Virol. 82: 4521-4526 [Abstract] [Full Text]  
  • Forrest, J. C., Paden, C. R., Allen, R. D. III, Collins, J., Speck, S. H. (2007). ORF73-Null Murine Gammaherpesvirus 68 Reveals Roles for mLANA and p53 in Virus Replication. J. Virol. 81: 11957-11971 [Abstract] [Full Text]  
  • Wang, W., Manna, D., Simmons, D. T. (2007). Role of the Hydrophilic Channels of Simian Virus 40 T-Antigen Helicase in DNA Replication. J. Virol. 81: 4510-4519 [Abstract] [Full Text]  
  • Wright, C. M., Fewell, S. W., Sullivan, M. L., Pipas, J. M., Watkins, S. C., Brodsky, J. L. (2007). The Hsp40 Molecular Chaperone Ydj1p, Along With the Protein Kinase C Pathway, Affects Cell-Wall Integrity in the Yeast Saccharomyces cerevisiae. Genetics 175: 1649-1664 [Abstract] [Full Text]  
  • Kustikova, O. S., Geiger, H., Li, Z., Brugman, M. H., Chambers, S. M., Shaw, C. A., Pike-Overzet, K., Ridder, D. d., Staal, F. J. T., Keudell, G. v., Cornils, K., Nattamai, K. J., Modlich, U., Wagemaker, G., Goodell, M. A., Fehse, B., Baum, C. (2007). Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood 109: 1897-1907 [Abstract] [Full Text]  
  • Matias, P. M., Gorynia, S., Donner, P., Carrondo, M. A. (2006). Crystal Structure of the Human AAA+ Protein RuvBL1. J. Biol. Chem. 281: 38918-38929 [Abstract] [Full Text]  
  • Guo, C., Wu, G., Chin, J. L., Bauman, G., Moussa, M., Wang, F., Greenberg, N. M., Taylor, S. S., Xuan, J. W. (2006). Bub1 Up-Regulation and Hyperphosphorylation Promote Malignant Transformation in SV40 Tag-Induced Transgenic Mouse Models. Mol Cancer Res 4: 957-969 [Abstract] [Full Text]  
  • Poulin, D. L., DeCaprio, J. A. (2006). Is There a Role for SV40 in Human Cancer?. JCO 24: 4356-4365 [Abstract] [Full Text]  
  • Zhou, Z., Flesken-Nikitin, A., Corney, D. C., Wang, W., Goodrich, D. W., Roy-Burman, P., Nikitin, A. Yu. (2006). Synergy of p53 and Rb Deficiency in a Conditional Mouse Model for Metastatic Prostate Cancer. Cancer Res. 66: 7889-7898 [Abstract] [Full Text]  
  • Kanehira, M., Kaifu, T., Maya, K., Kaji, M., Nakamura, A., Obinata, M., Takai, T. (2006). Novel Mast Cell Lines with Enhanced Proliferative and Degranulative Abilities Established from Temperature-Sensitive SV40 Large T Antigen Transgenic Mice. J Biochem 140: 211-220 [Abstract] [Full Text]  
  • Wen, C.-C., Cheng, S.-A., Hsuen, S.-P., Huang, Y.-L., Kuo, Z.-K., Lee, H.-F., Kuo, C.-H., Du, J.-L., Wang, W.-B. (2006). SV40 T/t-Common Polypeptide Specifically Induces Apoptosis in Human Cancer Cells that Overexpress HER2/neu. Cancer Res. 66: 5847-5857 [Abstract] [Full Text]  
  • Lu, B., Garrido, N., Spelbrink, J. N., Suzuki, C. K. (2006). Tid1 Isoforms Are Mitochondrial DnaJ-like Chaperones with Unique Carboxyl Termini That Determine Cytosolic Fate. J. Biol. Chem. 281: 13150-13158 [Abstract] [Full Text]  
  • Afonso, C. L., Tulman, E. R., Delhon, G., Lu, Z., Viljoen, G. J., Wallace, D. B., Kutish, G. F., Rock, D. L. (2006). Genome of crocodilepox virus.. J. Virol. 80: 4978-4991 [Abstract] [Full Text]  
  • Patel, A. K., Tikoo, S. K. (2006). 293T cells expressing simian virus 40 T antigen are semi-permissive to bovine adenovirus type 3 infection.. J. Gen. Virol. 87: 817-821 [Abstract] [Full Text]  
  • SULLIVAN, C.S., GRUNDHOFF, A., TEVETHIA, S., TREISMAN, R., PIPAS, J.M., GANEM, D. (2006). Expression and Function of MicroRNAs in Viruses Great and Small. Cold Spring Harb Symp Quant Biol 71: 351-356 [Abstract]  
  • Hill, R., Song, Y., Cardiff, R. D., Van Dyke, T. (2005). Heterogeneous Tumor Evolution Initiated by Loss of pRb Function in a Preclinical Prostate Cancer Model. Cancer Res. 65: 10243-10254 [Abstract] [Full Text]  
  • Goessel, G., Quante, M., Hahn, W. C., Harada, H., Heeg, S., Suliman, Y., Doebele, M., von Werder, A., Fulda, C., Nakagawa, H., Rustgi, A. K., Blum, H. E., Opitz, O. G. (2005). Creating oral squamous cancer cells: A cellular model of oral-esophageal carcinogenesis. Proc. Natl. Acad. Sci. USA 102: 15599-15604 [Abstract] [Full Text]  
  • Whalen, K. A., de Jesus, R., Kean, J. A., Schaffhausen, B. S. (2005). Genetic Analysis of the Polyomavirus DnaJ Domain. J. Virol. 79: 9982-9990 [Abstract] [Full Text]  
  • Vultur, A., Arulanandam, R., Turkson, J., Niu, G., Jove, R., Raptis, L. (2005). Stat3 Is Required for Full Neoplastic Transformation by the Simian Virus 40 Large Tumor Antigen. Mol. Biol. Cell 16: 3832-3846 [Abstract] [Full Text]  
  • Yu, Y., Kudchodkar, S. B., Alwine, J. C. (2005). Effects of Simian Virus 40 Large and Small Tumor Antigens on Mammalian Target of Rapamycin Signaling: Small Tumor Antigen Mediates Hypophosphorylation of eIF4E-Binding Protein 1 Late in Infection. J. Virol. 79: 6882-6889 [Abstract] [Full Text]  
  • Davido, D. J., von Zagorski, W. F., Lane, W. S., Schaffer, P. A. (2005). Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function. J. Virol. 79: 1232-1243 [Abstract] [Full Text]  
  • Zhang, Y.-H., Kooistra, K., Pietersen, A., Rohn, J. L., Noteborn, M. H. M. (2004). Activation of the Tumor-Specific Death Effector Apoptin and Its Kinase by an N-Terminal Determinant of Simian Virus 40 Large T Antigen. J. Virol. 78: 9965-9976 [Abstract] [Full Text]  
  • Weisshart, K., Friedl, S., Taneja, P., Nasheuer, H.-P., Schlott, B., Grosse, F., Fanning, E. (2004). Partial Proteolysis of Simian Virus 40 T Antigen Reveals Intramolecular Contacts between Domains and Conformation Changes upon Hexamer Assembly. J. Biol. Chem. 279: 38943-38951 [Abstract] [Full Text]  
  • Gai, D., Li, D., Finkielstein, C. V., Ott, R. D., Taneja, P., Fanning, E., Chen, X. S. (2004). Insights into the Oligomeric States, Conformational Changes, and Helicase Activities of SV40 Large Tumor Antigen. J. Biol. Chem. 279: 38952-38959 [Abstract] [Full Text]  
  • Uramoto, H., Hackzell, A., Wetterskog, D., Ballagi, A., Izumi, H., Funa, K. (2004). pRb, Myc and p53 are critically involved in SV40 large T antigen repression of PDGF {beta}-receptor transcription. J. Cell Sci. 117: 3855-3865 [Abstract] [Full Text]  
  • Vilchez, R. A., Butel, J. S. (2004). Emergent Human Pathogen Simian Virus 40 and Its Role in Cancer. Clin. Microbiol. Rev. 17: 495-508 [Abstract] [Full Text]  
  • Rohmer, L., Guttman, D. S., Dangl, J. L. (2004). Diverse Evolutionary Mechanisms Shape the Type III Effector Virulence Factor Repertoire in the Plant Pathogen Pseudomonas syringae. Genetics 167: 1341-1360 [Abstract] [Full Text]  
  • Peremyslov, V. V., Andreev, I. A., Prokhnevsky, A. I., Duncan, G. H., Taliansky, M. E., Dolja, V. V. (2004). Complex molecular architecture of beet yellows virus particles. Proc. Natl. Acad. Sci. USA 101: 5030-5035 [Abstract] [Full Text]  
  • Cotsiki, M., Lock, R. L., Cheng, Y., Williams, G. L., Zhao, J., Perera, D., Freire, R., Entwistle, A., Golemis, E. A., Roberts, T. M., Jat, P. S., Gjoerup, O. V. (2004). Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc. Natl. Acad. Sci. USA 101: 947-952 [Abstract] [Full Text]  
  • Lu, R., Nakajima, N., Hofmann, W., Benkirane, M., Teh-Jeang, K., Sodroski, J., Engelman, A. (2004). Simian Virus 40-Based Replication of Catalytically Inactive Human Immunodeficiency Virus Type 1 Integrase Mutants in Nonpermissive T Cells and Monocyte-Derived Macrophages. J. Virol. 78: 658-668 [Abstract] [Full Text]  
  • Jiao, J., Simmons, D. T. (2003). Nonspecific Double-Stranded DNA Binding Activity of Simian Virus 40 Large T Antigen Is Involved in Melting and Unwinding of the Origin. J. Virol. 77: 12720-12728 [Abstract] [Full Text]  
  • Genevaux, P., Lang, F., Schwager, F., Vartikar, J. V., Rundell, K., Pipas, J. M., Georgopoulos, C., Kelley, W. L. (2003). Simian Virus 40 T Antigens and J Domains: Analysis of Hsp40 Cochaperone Functions in Escherichia coli. J. Virol. 77: 10706-10713 [Abstract] [Full Text]  
  • Chromy, L. R., Pipas, J. M., Garcea, R. L. (2003). Chaperone-mediated in vitro assembly of Polyomavirus capsids. Proc. Natl. Acad. Sci. USA 100: 10477-10482 [Abstract] [Full Text]  
  • Gordon-Shaag, A., Yosef, Y., Abd El-Latif, M., Oppenheim, A. (2003). The Abundant Nuclear Enzyme PARP Participates in the Life Cycle of Simian Virus 40 and Is Stimulated by Minor Capsid Protein VP3. J. Virol. 77: 4273-4282 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»