Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

doi:10.1128/MMBR.66.4.630-670.2002

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Symington, L. S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Symington, L. S.

Previous Article | Next Article

Microbiology and Molecular Biology Reviews, December 2002, p. 630-670, Vol. 66, No. 4
1092-2172/02/$04.00+0 DOI: 10.1128/MMBR.66.4.630-670.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

Lorraine S. Symington^*

Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, New York 10032

The process of homologous recombination is a major DNA repairpathway that operates on DNA double-strand breaks, and possiblyother kinds of DNA lesions, to promote error-free repair. Centralto the process of homologous recombination are the RAD52 groupgenes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57,RAD59, MRE11, and XRS2), most of which were identified by theirrequirement for the repair of ionizing-radiation-induced DNAdamage in Saccharomyces cerevisiae. The Rad52 group proteinsare highly conserved among eukaryotes, and Rad51, Mre11, andRad50 are also conserved in prokaryotes and archaea. Recentstudies showing defects in homologous recombination and double-strandbreak repair in several human cancer-prone syndromes have emphasizedthe importance of this repair pathway in maintaining genomeintegrity. Although sensitivity to ionizing radiation is a universalfeature of rad52 group mutants, the mutants show considerableheterogeneity in different assays for recombinational repairof double-strand breaks and spontaneous mitotic recombination.Herein, I provide an overview of recent biochemical and structuralanalyses of the Rad52 group proteins and discuss how this informationcan be incorporated into genetic studies of recombination.

* Corresponding author. Mailing address: Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, 701 W. 168th Street, New York, NY 10032. Phone: (212) 305 4793. Fax: (212) 305-1741. E-mail: lss5{at}columbia.edu.

This article has been cited by other articles:

Liao, S., Toczylowski, T., Yan, H. (2008). Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. Nucleic Acids Res 36: 6091-6100 [Abstract] [Full Text]
Malik, P. S., Symington, L. S. (2008). Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2. Nucleic Acids Res 36: 6504-6510 [Abstract] [Full Text]
Plate, I., Hallwyl, S. C. L., Shi, I., Krejci, L., Muller, C., Albertsen, L., Sung, P., Mortensen, U. H. (2008). Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. J. Biol. Chem. 283: 29077-29085 [Abstract] [Full Text]
Banerjee, S., Smith, S., Oum, J.-H., Liaw, H.-J., Hwang, J.-Y., Sikdar, N., Motegi, A., Lee, S. E., Myung, K. (2008). Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. JCB 181: 1083-1093 [Abstract] [Full Text]
Sarai, N., Kagawa, W., Fujikawa, N., Saito, K., Hikiba, J., Tanaka, K., Miyagawa, K., Kurumizaka, H., Yokoyama, S. (2008). Biochemical analysis of the N-terminal domain of human RAD54B. Nucleic Acids Res 36: 5441-5450 [Abstract] [Full Text]
Kinner, A., Wu, W., Staudt, C., Iliakis, G. (2008). {gamma}-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36: 5678-5694 [Abstract] [Full Text]
Degtyareva, N. P., Chen, L., Mieczkowski, P., Petes, T. D., Doetsch, P. W. (2008). Chronic Oxidative DNA Damage Due to DNA Repair Defects Causes Chromosomal Instability in Saccharomyces cerevisiae. Mol. Cell. Biol. 28: 5432-5445 [Abstract] [Full Text]
Kagawa, W., Kagawa, A., Saito, K., Ikawa, S., Shibata, T., Kurumizaka, H., Yokoyama, S. (2008). Identification of a Second DNA Binding Site in the Human Rad52 Protein. J. Biol. Chem. 283: 24264-24273 [Abstract] [Full Text]
Kish, A., DiRuggiero, J. (2008). Rad50 Is Not Essential for the Mre11-Dependent Repair of DNA Double-Strand Breaks in Halobacterium sp. Strain NRC-1. J. Bacteriol. 190: 5210-5216 [Abstract] [Full Text]
Conde, F., San-Segundo, P. A. (2008). Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Pol{zeta}/Rev1. Genetics 179: 1197-1210 [Abstract] [Full Text]
Akamatsu, Y., Murayama, Y., Yamada, T., Nakazaki, T., Tsutsui, Y., Ohta, K., Iwasaki, H. (2008). Molecular Characterization of the Role of the Schizosaccharomyces pombe nip1+/ctp1+ Gene in DNA Double-Strand Break Repair in Association with the Mre11-Rad50-Nbs1 Complex. Mol. Cell. Biol. 28: 3639-3651 [Abstract] [Full Text]
Wu, Y., Kantake, N., Sugiyama, T., Kowalczykowski, S. C. (2008). Rad51 Protein Controls Rad52-mediated DNA Annealing. J. Biol. Chem. 283: 14883-14892 [Abstract] [Full Text]
Seong, C., Sehorn, M. G., Plate, I., Shi, I., Song, B., Chi, P., Mortensen, U., Sung, P., Krejci, L. (2008). Molecular Anatomy of the Recombination Mediator Function of Saccharomyces cerevisiae Rad52. J. Biol. Chem. 283: 12166-12174 [Abstract] [Full Text]
Glover, L., McCulloch, R., Horn, D. (2008). Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes. Nucleic Acids Res 36: 2608-2618 [Abstract] [Full Text]
Coic, E., Feldman, T., Landman, A. S., Haber, J. E. (2008). Mechanisms of Rad52-Independent Spontaneous and UV-Induced Mitotic Recombination in Saccharomyces cerevisiae. Genetics 179: 199-211 [Abstract] [Full Text]
Kwon, Y., Seong, C., Chi, P., Greene, E. C., Klein, H., Sung, P. (2008). ATP-dependent Chromatin Remodeling by the Saccharomyces cerevisiae Homologous Recombination Factor Rdh54. J. Biol. Chem. 283: 10445-10452 [Abstract] [Full Text]
Wray, J., Liu, J., Nickoloff, J. A., Shen, Z. (2008). Distinct RAD51 Associations with RAD52 and BCCIP in Response to DNA Damage and Replication Stress. Cancer Res. 68: 2699-2707 [Abstract] [Full Text]
Octobre, G., Lorenz, A., Loidl, J., Kohli, J. (2008). The Rad52 Homologs Rad22 and Rti1 of Schizosaccharomyces pombe Are Not Essential for Meiotic Interhomolog Recombination, but Are Required for Meiotic Intrachromosomal Recombination and Mating-Type-Related DNA Repair. Genetics 178: 2399-2412 [Abstract] [Full Text]
Busygina, V., Sehorn, M. G., Shi, I. Y., Tsubouchi, H., Roeder, G. S., Sung, P. (2008). Hed1 regulates Rad51-mediated recombination via a novel mechanism. Genes Dev. 22: 786-795 [Abstract] [Full Text]
Rostek, C., Turner, E. L., Robbins, M., Rightnar, S., Xiao, W., Obenaus, A., Harkness, T. A. A. (2008). Involvement of homologous recombination repair after proton-induced DNA damage. Mutagenesis 23: 119-129 [Abstract] [Full Text]
Wu, D., Topper, L. M., Wilson, T. E. (2008). Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae. Genetics 178: 1237-1249 [Abstract] [Full Text]
Mozlin, A. M., Fung, C. W., Symington, L. S. (2008). Role of the Saccharomyces cerevisiae Rad51 Paralogs in Sister Chromatid Recombination. Genetics 178: 113-126 [Abstract] [Full Text]
Curcio, M. J., Kenny, A. E., Moore, S., Garfinkel, D. J., Weintraub, M., Gamache, E. R., Scholes, D. T. (2007). S-Phase Checkpoint Pathways Stimulate the Mobility of the Retrovirus-Like Transposon Ty1. Mol. Cell. Biol. 27: 8874-8885 [Abstract] [Full Text]
Laun, P., Bruschi, C. V., Richard Dickinson, J., Rinnerthaler, M., Heeren, G., Schwimbersky, R., Rid, R., Breitenbach, M. (2007). Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. Nucleic Acids Res 0: gkm919v2-gkm919 [Abstract] [Full Text]
Hu, Y., Raynard, S., Sehorn, M. G., Lu, X., Bussen, W., Zheng, L., Stark, J. M., Barnes, E. L., Chi, P., Janscak, P., Jasin, M., Vogel, H., Sung, P., Luo, G. (2007). RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 21: 3073-3084 [Abstract] [Full Text]
Gangavarapu, V., Prakash, S., Prakash, L. (2007). Requirement of RAD52 Group Genes for Postreplication Repair of UV-Damaged DNA in Saccharomyces cerevisiae. Mol. Cell. Biol. 27: 7758-7764 [Abstract] [Full Text]
Cortes-Ledesma, F., Tous, C., Aguilera, A. (2007). Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication. Nucleic Acids Res 35: 6560-6570 [Abstract] [Full Text]
Markmann-Mulisch, U., Wendeler, E., Zobell, O., Schween, G., Steinbiss, H.-H., Reiss, B. (2007). Differential Requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana Development and DNA Damage Repair. Plant Cell 19: 3080-3089 [Abstract] [Full Text]
Mankouri, H. W., Ngo, H.-P., Hickson, I. D. (2007). Shu Proteins Promote the Formation of Homologous Recombination Intermediates That Are Processed by Sgs1-Rmi1-Top3. Mol. Biol. Cell 18: 4062-4073 [Abstract] [Full Text]
Wei, D. S., Rong, Y. S. (2007). A Genetic Screen For DNA Double-Strand Break Repair Mutations in Drosophila. Genetics 177: 63-77 [Abstract] [Full Text]
Mao, Z., Seluanov, A., Jiang, Y., Gorbunova, V. (2007). TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc. Natl. Acad. Sci. USA 104: 13068-13073 [Abstract] [Full Text]
Lee, K., Lee, S. E. (2007). Saccharomyces cerevisiae Sae2- and Tel1-Dependent Single-Strand DNA Formation at DNA Break Promotes Microhomology-Mediated End Joining. Genetics 176: 2003-2014 [Abstract] [Full Text]
Chi, P., San Filippo, J., Sehorn, M. G., Petukhova, G. V., Sung, P. (2007). Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev. 21: 1747-1757 [Abstract] [Full Text]
Mathew, R., Kongara, S., Beaudoin, B., Karp, C. M., Bray, K., Degenhardt, K., Chen, G., Jin, S., White, E. (2007). Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 21: 1367-1381 [Abstract] [Full Text]
Hope, J. C., Cruzata, L. D., Duvshani, A., Mitsumoto, J., Maftahi, M., Freyer, G. A. (2007). Mus81-Eme1-Dependent and -Independent Crossovers Form in Mitotic Cells during Double-Strand Break Repair in Schizosaccharomyces pombe. Mol. Cell. Biol. 27: 3828-3838 [Abstract] [Full Text]
Barnes, R. L., McCulloch, R. (2007). Trypanosoma brucei homologous recombination is dependent on substrate length and homology, though displays a differential dependence on mismatch repair as substrate length decreases. Nucleic Acids Res 35: 3478-3493 [Abstract] [Full Text]
Kearsey, S. E., Stevenson, A. L., Toda, T., Wang, S.-W. (2007). Fission Yeast Cut8 Is Required for the Repair of DNA Double-Strand Breaks, Ribosomal DNA Maintenance, and Cell Survival in the Absence of Rqh1 Helicase. Mol. Cell. Biol. 27: 1558-1567 [Abstract] [Full Text]
Carter, S. D., Iyer, S., Xu, J., McEachern, M. J., Astrom, S. U. (2007). The Role Of Nonhomologous End-Joining Components in Telomere Metabolism in Kluyveromyces lactis. Genetics 175: 1035-1045 [Abstract] [Full Text]
Moehle, E. A., Rock, J. M., Lee, Y.-L., Jouvenot, Y., DeKelver, R. C., Gregory, P. D., Urnov, F. D., Holmes, M. C. (2007). Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc. Natl. Acad. Sci. USA 104: 3055-3060 [Abstract] [Full Text]
Grandin, N., Charbonneau, M. (2007). Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA. Nucleic Acids Res 35: 822-838 [Abstract] [Full Text]
Dutra, B. E., Sutera, V. A. Jr., Lovett, S. T. (2007). RecA-independent recombination is efficient but limited by exonucleases. Proc. Natl. Acad. Sci. USA 104: 216-221 [Abstract] [Full Text]
Wu, Y., Siino, J. S., Sugiyama, T., Kowalczykowski, S. C. (2006). The DNA Binding Preference of RAD52 and RAD59 Proteins: IMPLICATIONS FOR RAD52 AND RAD59 PROTEIN FUNCTION IN HOMOLOGOUS RECOMBINATION. J. Biol. Chem. 281: 40001-40009 [Abstract] [Full Text]
Fung, C. W., Fortin, G. S., Peterson, S. E., Symington, L. S. (2006). The rad51-K191R ATPase-Defective Mutant Is Impaired for Presynaptic Filament Formation. Mol. Cell. Biol. 26: 9544-9554 [Abstract] [Full Text]
Johnson-Schlitz, D., Engels, W. R. (2006). Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Proc. Natl. Acad. Sci. USA 103: 16840-16845 [Abstract] [Full Text]
Toczylowski, T., Yan, H. (2006). Mechanistic Analysis of a DNA End Processing Pathway Mediated by the Xenopus Werner Syndrome Protein. J. Biol. Chem. 281: 33198-33205 [Abstract] [Full Text]
McCaffrey, R., St Johnston, D., Gonzalez-Reyes, A. (2006). Drosophila mus301/spindle-C Encodes a Helicase With an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression. Genetics 174: 1273-1285 [Abstract] [Full Text]
Storici, F., Snipe, J. R., Chan, G. K., Gordenin, D. A., Resnick, M. A. (2006). Conservative Repair of a Chromosomal Double-Strand Break by Single-Strand DNA through Two Steps of Annealing. Mol. Cell. Biol. 26: 7645-7657 [Abstract] [Full Text]
Kovalenko, O. V., Wiese, C., Schild, D. (2006). RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Nucleic Acids Res 0: gkl665v3-12 [Abstract] [Full Text]
Holzen, T. M., Shah, P. P., Olivares, H. A., Bishop, D. K. (2006). Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin. Genes Dev. 20: 2593-2604 [Full Text]
Sarai, N., Kagawa, W., Kinebuchi, T., Kagawa, A., Tanaka, K., Miyagawa, K., Ikawa, S., Shibata, T., Kurumizaka, H., Yokoyama, S. (2006). Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein. Nucleic Acids Res 34: 4429-4437 [Abstract] [Full Text]
Fanning, E., Klimovich, V., Nager, A. R. (2006). A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res 34: 4126-4137 [Abstract] [Full Text]
Heyer, W.-D., Li, X., Rolfsmeier, M., Zhang, X.-P. (2006). Rad54: the Swiss Army knife of homologous recombination?. Nucleic Acids Res 34: 4115-4125 [Abstract] [Full Text]
Chi, P., Kwon, Y., Seong, C., Epshtein, A., Lam, I., Sung, P., Klein, H. L. (2006). Yeast Recombination Factor Rdh54 Functionally Interacts with the Rad51 Recombinase and Catalyzes Rad51 Removal from DNA. J. Biol. Chem. 281: 26268-26279 [Abstract] [Full Text]
Lopes, J., Ribeyre, C., Nicolas, A. (2006). Complex Minisatellite Rearrangements Generated in the Total or Partial Absence of Rad27/hFEN1 Activity Occur in a Single Generation and Are Rad51 and Rad52 Dependent.. Mol. Cell. Biol. 26: 6675-6689 [Abstract] [Full Text]
Papamichos-Chronakis, M., Krebs, J. E., Peterson, C. L. (2006). Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptationin response to DNA damage. Genes Dev. 20: 2437-2449 [Abstract] [Full Text]
Valencia-Burton, M., Oki, M., Johnson, J., Seier, T. A., Kamakaka, R., Haber, J. E. (2006). Different Mating-Type-Regulated Genes Affect the DNA Repair Defects of Saccharomyces RAD51, RAD52 and RAD55 Mutants. Genetics 174: 41-55 [Abstract] [Full Text]
Barbera, M. A., Petes, T. D. (2006). Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 103: 12819-12824 [Abstract] [Full Text]
Vasileva, A., Linden, R. M., Jessberger, R. (2006). Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Res 34: 3345-3360 [Abstract] [Full Text]
Kiianitsa, K., Solinger, J. A., Heyer, W.-D. (2006). Terminal association of Rad54 protein with the Rad51-dsDNA filament. Proc. Natl. Acad. Sci. USA 103: 9767-9772 [Abstract] [Full Text]
Wu, Y., Sugiyama, T., Kowalczykowski, S. C. (2006). DNA Annealing Mediated by Rad52 and Rad59 Proteins. J. Biol. Chem. 281: 15441-15449 [Abstract] [Full Text]
Raynard, S., Bussen, W., Sung, P. (2006). A Double Holliday Junction Dissolvasome Comprising BLM, Topoisomerase III{alpha}, and BLAP75. J. Biol. Chem. 281: 13861-13864 [Abstract] [Full Text]
Thorpe, P. H., Marrero, V. A., Savitzky, M. H., Sunjevaric, I., Freeman, T. C., Rothstein, R. (2006). Cells Expressing Murine RAD52 Splice Variants Favor Sister Chromatid Repair. Mol. Cell. Biol. 26: 3752-3763 [Abstract] [Full Text]
Filippo, J. S., Chi, P., Sehorn, M. G., Etchin, J., Krejci, L., Sung, P. (2006). Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide. J. Biol. Chem. 281: 11649-11657 [Abstract] [Full Text]
Hope, J. C., Mense, S. M., Jalakas, M., Mitsumoto, J., Freyer, G. A. (2006). Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity. Proc. Natl. Acad. Sci. USA 103: 5875-5880 [Abstract] [Full Text]
Cost, G. J., Cozzarelli, N. R. (2006). Smc5p Promotes Faithful Chromosome Transmission and DNA Repair in Saccharomyces cerevisiae. Genetics 172: 2185-2200 [Abstract] [Full Text]
Kegel, A., Martinez, P., Carter, S. D., Astrom, S. U. (2006). Genome wide distribution of illegitimate recombination events in Kluyveromyces lactis. Nucleic Acids Res 34: 1633-1645 [Abstract] [Full Text]
Wijeratne, A. J., Chen, C., Zhang, W., Timofejeva, L., Ma, H. (2006). The Arabidopsis thaliana PARTING DANCERS Gene Encoding a Novel Protein Is Required for Normal Meiotic Homologous Recombination. Mol. Biol. Cell 17: 1331-1343 [Abstract] [Full Text]
Motegi, A., Kuntz, K., Majeed, A., Smith, S., Myung, K. (2006). Regulation of Gross Chromosomal Rearrangements by Ubiquitin and SUMO Ligases in Saccharomyces cerevisiae. Mol. Cell. Biol. 26: 1424-1433 [Abstract] [Full Text]
Banerjee, S., Smith, S., Myung, K. (2006). Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints. Proc. Natl. Acad. Sci. USA 103: 1816-1821 [Abstract] [Full Text]
Wesoly, J., Agarwal, S., Sigurdsson, S., Bussen, W., Van Komen, S., Qin, J., van Steeg, H., van Benthem, J., Wassenaar, E., Baarends, W. M., Ghazvini, M., Tafel, A. A., Heath, H., Galjart, N., Essers, J., Grootegoed, J. A., Arnheim, N., Bezzubova, O., Buerstedde, J.-M., Sung, P., Kanaar, R. (2006). Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis. Mol. Cell. Biol. 26: 976-989 [Abstract] [Full Text]
Graneli, A., Yeykal, C. C., Robertson, R. B., Greene, E. C. (2006). Long-distance lateral diffusion of human Rad51 on double-stranded DNA. Proc. Natl. Acad. Sci. USA 103: 1221-1226 [Abstract] [Full Text]
Weinstock, D. M., Jasin, M. (2006). Alternative Pathways for the Repair of RAG-Induced DNA Breaks. Mol. Cell. Biol. 26: 131-139 [Abstract] [Full Text]
Ohya, Y., Sese, J., Yukawa, M., Sano, F., Nakatani, Y., Saito, T. L., Saka, A., Fukuda, T., Ishihara, S., Oka, S., Suzuki, G., Watanabe, M., Hirata, A., Ohtani, M., Sawai, H., Fraysse, N., Latge, J.-P., Francois, J. M., Aebi, M., Tanaka, S., Muramatsu, S., Araki, H., Sonoike, K., Nogami, S., Morishita, S. (2005). High-dimensional and large-scale phenotyping of yeast mutants. Proc. Natl. Acad. Sci. USA 102: 19015-19020 [Abstract] [Full Text]
Proudfoot, C., McCulloch, R. (2005). Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation. Nucleic Acids Res 33: 6906-6919 [Abstract] [Full Text]
Krogh, B. O., Llorente, B., Lam, A., Symington, L. S. (2005). Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity. Genetics 171: 1561-1570 [Abstract] [Full Text]
Niu, H., Wan, L., Baumgartner, B., Schaefer, D., Loidl, J., Hollingsworth, N. M. (2005). Partner Choice during Meiosis Is Regulated by Hop1-promoted Dimerization of Mek1. Mol. Biol. Cell 16: 5804-5818 [Abstract] [Full Text]
Kamisugi, Y., Cuming, A. C., Cove, D. J. (2005). Parameters determining the efficiency of gene targeting in the moss Physcomitrella patens. Nucleic Acids Res 33: e173-e173 [Abstract] [Full Text]
Zhang, H., Lawrence, C. W. (2005). The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination. Proc. Natl. Acad. Sci. USA 102: 15954-15959 [Abstract] [Full Text]
Kateneva, A. V., Konovchenko, A. A., Guacci, V., Dresser, M. E. (2005). Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae. JCB 171: 241-253 [Abstract] [Full Text]
Yan, H., McCane, J., Toczylowski, T., Chen, C. (2005). Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. JCB 171: 217-227 [Abstract] [Full Text]
Arai, N., Ito, D., Inoue, T., Shibata, T., Takahashi, H. (2005). Heteroduplex Joint Formation by a Stoichiometric Complex of Rad51 and Rad52 of Saccharomyces cerevisiae. J. Biol. Chem. 280: 32218-32229 [Abstract] [Full Text]
Morishita, T., Furukawa, F., Sakaguchi, C., Toda, T., Carr, A. M., Iwasaki, H., Shinagawa, H. (2005). Role of the Schizosaccharomyces pombe F-Box DNA Helicase in Processing Recombination Intermediates. Mol. Cell. Biol. 25: 8074-8083 [Abstract] [Full Text]

Appl. Environ. Microbiol.	Infect. Immun.	Eukaryot. Cell
Mol. Cell. Biol.	J. Virol.	J. Bacteriol.
	ALL ASM JOURNALS