This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gottesman, M. E.
Right arrow Articles by Weisberg, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gottesman, M. E.
Right arrow Articles by Weisberg, R. A.

 Previous Article

Microbiology and Molecular Biology Reviews, December 2004, p. 796-813, Vol. 68, No. 4
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.4.796-813.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Little Lambda, Who Made Thee?{dagger}

Max E. Gottesman1* and Robert A. Weisberg2

Institute of Cancer Research, Columbia University, New York, New York,1 Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, Maryland2

The study of the bacteriophage {lambda} has been critical to the discipline of molecular biology. It was the source of key discoveries in the mechanisms of, among other processes, gene regulation, recombination, and transcription initiation and termination. We trace here the events surrounding these findings and draw on the recollections of the participants. We show how a particular atmosphere of interactions among creative scientists yielded spectacular insights into how living things work.

* Corresponding author. Mailing address: Institute of Cancer Research, Columbia University, 701 W. 168th St., New York, NY 10032. Phone: (212) 305-6900. Fax: (301) 496-0243. E-mail: gottesman{at}cuccfa.ccc.columbia.edu.

{dagger} With apologies to William Blake.

Microbiology and Molecular Biology Reviews, December 2004, p. 796-813, Vol. 68, No. 4
1092-2172/04/$08.00+0     DOI: 10.1128/MMBR.68.4.796-813.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»