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Microbiology and Molecular Biology Reviews, September 2005, p. 393-425, Vol. 69, No. 3
1092-2172/05/$08.00+0     doi:10.1128/MMBR.69.3.393-425.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Posttranslational Protein Modification in Archaea

Jerry Eichler1* and Michael W. W. Adams2

Department of Life Sciences, Ben Gurion University, Beersheva, 84105 Israel,1 Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 306022

One of the first hurdles to be negotiated in the postgenomic era involves the description of the entire protein content of the cell, the proteome. Such efforts are presently complicated by the various posttranslational modifications that proteins can experience, including glycosylation, lipid attachment, phosphorylation, methylation, disulfide bond formation, and proteolytic cleavage. Whereas these and other posttranslational protein modifications have been well characterized in Eucarya and Bacteria, posttranslational modification in Archaea has received far less attention. Although archaeal proteins can undergo posttranslational modifications reminiscent of what their eucaryal and bacterial counterparts experience, examination of archaeal posttranslational modification often reveals aspects not previously observed in the other two domains of life. In some cases, posttranslational modification allows a protein to survive the extreme conditions often encountered by Archaea. The various posttranslational modifications experienced by archaeal proteins, the molecular steps leading to these modifications, and the role played by posttranslational modification in Archaea form the focus of this review.

* Corresponding author. Mailing address: Dept. of Life Sciences, Ben Gurion University, P.O. Box 653, Beersheva 84105, Israel. Phone: 972 8646 1343. Fax: 972 8647 9175. E-mail: jeichler{at}bgu.ac.il.

Microbiology and Molecular Biology Reviews, September 2005, p. 393-425, Vol. 69, No. 3
1092-2172/05/$08.00+0     doi:10.1128/MMBR.69.3.393-425.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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