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Review

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

Frédéric Pâques, James E. Haber
Frédéric Pâques
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110
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James E. Haber
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110
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DOI: 10.1128/MMBR.63.2.349-404.1999
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SUMMARY

SUMMARY The budding yeast Saccharomyces cerevisiae has been the principal organism used in experiments to examine genetic recombination in eukaryotes. Studies over the past decade have shown that meiotic recombination and probably most mitotic recombination arise from the repair of double-strand breaks (DSBs). There are multiple pathways by which such DSBs can be repaired, including several homologous recombination pathways and still other nonhomologous mechanisms. Our understanding has also been greatly enriched by the characterization of many proteins involved in recombination and by insights that link aspects of DNA repair to chromosome replication. New molecular models of DSB-induced gene conversion are presented. This review encompasses these different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.

  • Copyright © 1999 American Society for Microbiology
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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques, James E. Haber
Microbiology and Molecular Biology Reviews Jun 1999, 63 (2) 349-404; DOI: 10.1128/MMBR.63.2.349-404.1999

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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques, James E. Haber
Microbiology and Molecular Biology Reviews Jun 1999, 63 (2) 349-404; DOI: 10.1128/MMBR.63.2.349-404.1999
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    • SUMMARY
    • GENERAL STRATEGIES TO STUDY DNA RECOMBINATION AND REPAIR
    • DIFFERENT MECHANISMS OF HOMOLOGOUS DSB REPAIR
    • PROTEINS INVOLVED IN MITOTIC RECOMBINATION
    • STIMULATION OF MITOTIC RECOMBINATION
    • MEIOTIC RECOMBINATION
    • SEARCH FOR HOMOLOGOUS SEQUENCES: ECTOPIC RECOMBINATION
    • ROLE OF MISMATCH REPAIR PROTEINS IN RECOMBINATION
    • ROLE OF DSB REPAIR IN TANDEM REPEAT INSTABILITY
    • MITOTIC NONHOMOLOGOUS RECOMBINATION
    • DSB REPAIR CHECKPOINTS
    • FUTURE DIRECTIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
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KEYWORDS

DNA Repair
DNA, Fungal
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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