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Review

Defenses against Oxidative Stress in Neisseria gonorrhoeae: a System Tailored for a Challenging Environment

Kate L. Seib, Hsing-Ju Wu, Stephen P. Kidd, Michael A. Apicella, Michael P. Jennings, Alastair G. McEwan
Kate L. Seib
1The School of Molecular and Microbial Sciences & Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia
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Hsing-Ju Wu
2Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
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Stephen P. Kidd
1The School of Molecular and Microbial Sciences & Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia
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Michael A. Apicella
3Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242
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Michael P. Jennings
1The School of Molecular and Microbial Sciences & Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia
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Alastair G. McEwan
1The School of Molecular and Microbial Sciences & Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia
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  • For correspondence: mcewan@uq.edu.au
DOI: 10.1128/MMBR.00044-05
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SUMMARY

SUMMARY Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species as a consequence of localized inflammatory responses in the urethra of males and endocervix of females and also of the activity of commensal lactobacilli in the vaginal flora. This review describes recent advances in the understanding of defense systems against oxidative stress in N. gonorrhoeae and shows that while some of its defenses have similarities to the paradigm established with Escherichia coli, there are also some key differences. These differences include the presence of a defense system against superoxide based on manganese ions and a glutathione-dependent system for defense against nitric oxide which is under the control of a novel MerR-like transcriptional regulator. An understanding of the defenses against oxidative stress in N. gonorrhoeae and their regulation may provide new insights into the ways in which this bacterium survives challenges from polymorphonuclear leukocytes and urogenital epithelial cells.

  • Copyright © 2006 American Society for Microbiology
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Defenses against Oxidative Stress in Neisseria gonorrhoeae: a System Tailored for a Challenging Environment
Kate L. Seib, Hsing-Ju Wu, Stephen P. Kidd, Michael A. Apicella, Michael P. Jennings, Alastair G. McEwan
Microbiology and Molecular Biology Reviews Jun 2006, 70 (2) 344-361; DOI: 10.1128/MMBR.00044-05

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Defenses against Oxidative Stress in Neisseria gonorrhoeae: a System Tailored for a Challenging Environment
Kate L. Seib, Hsing-Ju Wu, Stephen P. Kidd, Michael A. Apicella, Michael P. Jennings, Alastair G. McEwan
Microbiology and Molecular Biology Reviews Jun 2006, 70 (2) 344-361; DOI: 10.1128/MMBR.00044-05
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  • Top
  • Article
    • SUMMARY
    • INTRODUCTION
    • SOURCES OF OXIDATIVE STRESS
    • DEFENSES AGAINST OXIDATIVE STRESS IN N. GONORRHOEAE
    • CONCLUDING REMARKS
    • ADDENDUM IN PROOF
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Neisseria gonorrhoeae
oxidative stress

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