DOI: 10.1128/MMBR.00008-11
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PubMed
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History
- Published online September 1, 2011.
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Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Author Information
- Alan G. Hinnebusch*
- Laboratory of Gene Regulation and Development, Eunice K. Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
- ↵*Mailing address: Laboratory of Gene Regulation and Development, Eunice K. Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 496-4480. Fax: (301) 496-0243. E-mail: alanh{at}mail.nih.gov.
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- Top
- Article
- SUMMARY
- INTRODUCTION
- OVERVIEW OF TRANSLATION INITIATION BY THE SCANNING MECHANISM
- FEATURES OF THE SCANNING MECHANISM AND EXCEPTIONS TO THE “FIRST-AUG RULE”
- GENETIC IDENTIFICATION OF FACTORS INVOLVED IN ACCURATE AUG SELECTION
- eIF1 PROMOTES SCANNING, IMPEDES GTP HYDROLYSIS BY THE TC, AND PREVENTS TIGHT BINDING OF Met-tRNAiMet TO THE P SITE AT NON-AUG CODONS
- EVIDENCE THAT eIF5 PROMOTES eIF1 DISSOCIATION AT START CODONS
- eIF1A PLAYS A DIRECT ROLE IN SCANNING AND AUG RECOGNITION FROM THE A SITE OF THE 40S SUBUNIT
- INITIATOR tRNA AND 18S rRNA RESIDUES INVOLVED IN AUG RECOGNITION
- STRUCTURAL DETERMINANTS OF STRINGENT AUG SELECTION IN SUBUNITS OF eIF2
- FUNCTIONS OF eIF3 SUBUNITS IN 43S ATTACHMENT, SCANNING, AND START CODON RECOGNITION
- ROLES OF RNA HELICASES eIF4A, Ded1, AND Dhx29 IN RIBOSOME ATTACHMENT AND SCANNING
- PERSPECTIVES
- ACKNOWLEDGMENTS
- REFERENCES
- Figures & Data
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