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Review

Kinetic Modeling of Virus Growth in Cells

John Yin, Jacob Redovich
John Yin
aDepartment of Chemical and Biological Engineering, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Jacob Redovich
aDepartment of Chemical and Biological Engineering, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA
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DOI: 10.1128/MMBR.00066-17
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SUMMARY

When a virus infects a host cell, it hijacks the biosynthetic capacity of the cell to produce virus progeny, a process that may take less than an hour or more than a week. The overall time required for a virus to reproduce depends collectively on the rates of multiple steps in the infection process, including initial binding of the virus particle to the surface of the cell, virus internalization and release of the viral genome within the cell, decoding of the genome to make viral proteins, replication of the genome, assembly of progeny virus particles, and release of these particles into the extracellular environment. For a large number of virus types, much has been learned about the molecular mechanisms and rates of the various steps. However, in only relatively few cases during the last 50 years has an attempt been made—using mathematical modeling—to account for how the different steps contribute to the overall timing and productivity of the infection cycle in a cell. Here we review the initial case studies, which include studies of the one-step growth behavior of viruses that infect bacteria (Qβ, T7, and M13), human immunodeficiency virus, influenza A virus, poliovirus, vesicular stomatitis virus, baculovirus, hepatitis B and C viruses, and herpes simplex virus. Further, we consider how such models enable one to explore how cellular resources are utilized and how antiviral strategies might be designed to resist escape. Finally, we highlight challenges and opportunities at the frontiers of cell-level modeling of virus infections.

  • Copyright © 2018 American Society for Microbiology.

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Kinetic Modeling of Virus Growth in Cells
John Yin, Jacob Redovich
Microbiology and Molecular Biology Reviews Mar 2018, 82 (2) e00066-17; DOI: 10.1128/MMBR.00066-17

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Kinetic Modeling of Virus Growth in Cells
John Yin, Jacob Redovich
Microbiology and Molecular Biology Reviews Mar 2018, 82 (2) e00066-17; DOI: 10.1128/MMBR.00066-17
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  • Top
  • Article
    • SUMMARY
    • INTRODUCTION
    • EARLY MODELS OF VIRUS GROWTH
    • BACTERIOPHAGE Qβ
    • BACTERIOPHAGE T7
    • BACTERIOPHAGE M13
    • HIV-1
    • INFLUENZA A VIRUS
    • POLIOVIRUS
    • VSV
    • BACULOVIRUS
    • HBV
    • HCV
    • HSV-1
    • FRONTIERS FOR MODELING VIRUS GROWTH IN CELLS
    • ACKNOWLEDGMENTS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

DNA virus
RNA virus
bacteriophages
biophysics
computational biology
computer modeling
growth modeling
kinetics
mathematical modeling
molecular biology

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