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Review

Response Mechanisms of Invertebrates to Bacillus thuringiensis and Its Pesticidal Proteins

Daniel Pinos, Ascensión Andrés-Garrido, Juan Ferré, Patricia Hernández-Martínez
Daniel Pinos
aInstituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain
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Ascensión Andrés-Garrido
aInstituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain
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Juan Ferré
aInstituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain
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Patricia Hernández-Martínez
aInstituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain
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DOI: 10.1128/MMBR.00007-20
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SUMMARY

Extensive use of chemical insecticides adversely affects both environment and human health. One of the most popular biological pest control alternatives is bioinsecticides based on Bacillus thuringiensis. This entomopathogenic bacterium produces different protein types which are toxic to several insect, mite, and nematode species. Currently, insecticidal proteins belonging to the Cry and Vip3 groups are widely used to control insect pests both in formulated sprays and in transgenic crops. However, the benefits of B. thuringiensis-based products are threatened by insect resistance evolution. Numerous studies have highlighted that mutations in genes coding for surrogate receptors are responsible for conferring resistance to B. thuringiensis. Nevertheless, other mechanisms may also contribute to the reduction of the effectiveness of B. thuringiensis-based products for managing insect pests and even to the acquisition of resistance. Here, we review the relevant literature reporting how invertebrates (mainly insects and Caenorhabditis elegans) respond to exposure to B. thuringiensis as either whole bacteria, spores, and/or its pesticidal proteins.

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Response Mechanisms of Invertebrates to Bacillus thuringiensis and Its Pesticidal Proteins
Daniel Pinos, Ascensión Andrés-Garrido, Juan Ferré, Patricia Hernández-Martínez
Microbiology and Molecular Biology Reviews Jan 2021, 85 (1) e00007-20; DOI: 10.1128/MMBR.00007-20

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Response Mechanisms of Invertebrates to Bacillus thuringiensis and Its Pesticidal Proteins
Daniel Pinos, Ascensión Andrés-Garrido, Juan Ferré, Patricia Hernández-Martínez
Microbiology and Molecular Biology Reviews Jan 2021, 85 (1) e00007-20; DOI: 10.1128/MMBR.00007-20
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  • Top
  • Article
    • SUMMARY
    • INTRODUCTION
    • INGESTION
    • CRYSTAL SOLUBILIZATION
    • ACTIVATION
    • TOXIN SEQUESTRATION
    • GUT EPITHELIUM HEALING
    • EPITHELIUM INTRINSIC CELLULAR DEFENSE PATHWAYS
    • REPAT PROTEINS
    • IMMUNE RESPONSES
    • FINAL CONSIDERATIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

INCED mechanisms
REPAT proteins
apoptotic death
autophagy
gut epithelium healing
immune priming
immune response
toxin sequestration
transgenerational immune priming
vesicle trafficking pathways

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