Table 3.

Survey of eubacterial SSR-containing genes with a known function

SpeciesRepeat motifGeneLevel of regulationGene functionReference(s)
TranscriptionTranslation/protein
H. influenzaeCAATlic1–lic3+LPS biosynthesisa83, 211, 212
GCAAyadA+Adhesin (Yersinia homolog)83
GACAlgtC+Glycosyltransferase83
TTGGNDf+Iron binding proteins83
AGTCND+Restriction modification, methyltransferase83
TTTAND+UnknownBacillus homolog83
TAhifA/B+Synthesis of fimbriae199, 200
N. meningitidisGlsi2+LPS biosynthesis18
CTCTTopa+Opacity surface proteins119
Aopa+Opacity surface proteins119
GporA+OMP198
S. aureusb93 bpfnb+Fibronectin binding protein139
561 bpcna+Collagen adhesin140
81 bpcoa+Coagulase65, 165
GAAGAXXXXAAXAAXCCTXGXAAAspa+Protein A27
GAXTCXGAXTCXGAXAGXclf+Clumping factor, fibrinogen receptor116, 117
Streptococcus spp.60 bppspA+Pneumococcal surface proteinc219
69 bpemm+Phagocytosis resistance M protein6
246 bpαC+αC protein (antibody-mediated killing)67
E. faecalisTAGTARRrep1 and rep2+Iteron, regulates plasmid replication and transfer72
M. hyorhinusd36 and 39 bpvlp+Variant membrane lipoprotein218
Avlp+Variant membrane lipoprotein218
M. bovis24 bpvspA+Membrane surface lipoprotein107
M. fermentansAP78+Lipoprotein in ABC transporter complex183
U. urealyticumGGTAAAGAACAACCAGCAMB+Serology-specific MB antigen222
B. anthracisCAATATCAACAAvvrA+Microfilarial sheath protein homolog87
L. monocytogenes66 bpprfA+Leucine-rich internalin like protein37
E. coliA and Celac+β-Galactosidase52, 156
A. marginale 87 bpmsp1α+Major surface protein2
  • a Homologues for these sequences have been described for Moraxella catharralis and the human pathogenic Neisseria species.

  • b The genes described for this species all produce MSCRAMMs.

  • c Homologous structures were identified in diverse streptococci and Clostridium difficile.

  • d See Table 2 for the analysis of M. genitalium and M. pneumoniae on the basis of the whole genome sequences as available.

  • e Homopolymeric tracts.

  • f ND, not defined.