Table 1.

S. pombe genes that govern mating and meiosis

GeneProductReference(s)
Required by M and P cells
 fus1 Fusion protein 163
 map1 MADS box protein required for P-specific gene expression and enhancement of M-specific gene expression 151, 226
 mei2 RNA binding protein required for initiation of meiosis 219
 ste6 GEF for Ras1 80
 ste11 HMG-box transcription activator 199
 gpa1 Gα subunit coupled to pheromone receptors 154
 ras1 Homolog of mammalian Ras 145
 byr2 MAPKKK 213
 byr1 MAPKK 145
 spk1 MAPK 205
Required by M cells
 mam1 M-factor ABC transporter 33
 mam2 P-factor receptor 98
 mfm1 M-factor precursor 1 42
 mfm2 M-factor precursor 2 42
 mfm3 M-factor precursor 3 100
 sxa2 Protease that degrades P-factor 86
 mat1-Mc HMG-box regulatory protein required for M-cell-specific gene expression 99
 mat1-Mm Mating-type regulatory protein required for meiosis 228a
Required by P cells
 mat1-Pc Mating-type regulatory protein required for P-cell-specific gene expression 228a
 mat1-Pm Mating-type regulatory protein of the homeodomain family required for meiosis 228a
 map2 P-factor precursor gene 85
 map3 Receptor for M-factor 202
 sxa1 Protease that degrades M-factor 86