Table 4.

Prokaryotic and eukaryotic proteins known or believed to possess internal amide-linked acyl groups

ProteinTotal no. of amino acidsAcyl donorModified residueAcyl group
Prokaryotic
 Pore-forming toxins
  E. coliHlyA1,024Acyl-ACPK564?a
K690?a
  B. pertussisCyaA1,706Acyl-ACP?K860bC16b
K983C14b, C16
Eukaryotic
 Inflammatory cytokines
  TNF-α233Acyl-CoAK19C14
K20C14
  IL-1α271Acyl-CoAK82cC14
K83cC14
 Mitogenic receptors
  Insulin receptor (α and β)1,382??C14, C16
  Immunoglobulin
   μm593??C14
   μs572??C14
 Cholinergic receptors
  Nicotinic acetylcholine receptor
   α457??C16
   β501??C16
 Membrane complexes
  cytochrome coxidase (subunit 1)557Acyl-ACP?K324C14
  • a C14 preferred substrate in vitro.

  • b Acylated in E. coli only.

  • c Monoacylated preferred product.