Table 5.

Control of Yop release

ProteinSize (kDa)Structural featuresaRole(s)LocalizationRelevant similaritiesReferences
Minus Ca2+Plus Ca2+
YopN32.6Coiled-coil structures (aa 62–108 and aa 248–272)Element of the putative plug closing the secretion channel; associated with TyeASecreted, cytosolicCytosolic, surface associatedMxiC (Shigellaspp.); InvE (Salmonella spp.); PopN (P. aeruginosa); HrpI (E. amylovora); CopN (C. psittaci) 6, 38, 99, 117, 165, 172, 379
TyeA10.8Element of the putative plug closing the secretion channel; binds to the second coiled-coil domain of YopN; binds to YopD; required for translocation of YopE and YopH but not YopM, YopO, YopP, YopTSurface associated, cytosolicSurface associated, cytosolicPcr1 (P. aeruginosa); SsaL (Salmonella spp.) 99, 154, 170, 172, 360,379
LcrG11.0Forms dimers; heparin-binding domainInvolved in control of secretion; required for efficient delivery of all Yop effectors; binds to heparan proteoglycansMainly cytosolicMainly cytosolicPcrG (P. aeruginosa) 48, 246a, 247, 294, 295, 311, 312,379
  • a aa, amino acids.