Table 4.

Yop proteins involved in translocation

ProteinSize (kDa)Structural featuresaRole(s)Relevant similaritiesReferences
YopB41.8Central hydrophobic domains (aa 168–208 and aa 224–258); coiled coils (aa 103–165 and aa 330–385)Needed for translocation; needed for contact hemolysis; hypothetical constituent of a poreRTX toxin (LktA, HlyA, …); IpaB (S. flexneri); PopB (P. aeruginosa); YopD; EspB (EPEC); SipB (S. typhimurium) 41, 136, 138, 146, 183,190, 224, 321, 379
YopD33.3Central hydrophobic domain (aa 122–152); coiled coils (aa 249–292); C-terminal amphipathic α-helixNeeded for translocationPopD (P. aeruginosa); YopB 41, 136, 259, 321, 379
LcrV37.2PolymorphismRequired for extrusion of YopB and YopDPcrV (P. aeruginosa) 270, 276, 294,379
YopK/YopQ20.8NoneControls translocation by modulating the size of the YopB-induced poreNone 161, 162
  • a aa, amino acids.