Table 1.

Functions of P. gingivalis proteinasesa

Impairment of tissue integrityPerturbation of host defensesBacterial function
Degradation of extracellular matrix proteins (fibronectin, laminin)Degradation of immunoglobulinsRelease of hemin and iron from host proteins
Hydrolysis of collagens I, III, IV, and VInactivation or activation of complement componentsExposure of host and bacterial cryptitopes
Degradation of fibrinogenDestruction of cytokines and chemokinesPosttranslational processing of proteases, fimbrillin, and outer membrane proteins
Inactivation of tissue and plasma proteinase inhibitorsCleavage of leukocyte surface receptorsInvolvement in intracellular invasion
Activation of matrix metalloproteinasesDegradation of antimicrobial peptides
Activation of the kallikrein/kinin cascade
  • ↵a Compiled from references 1, 3,16, 30, 35, 38, 45, 51, 62, 74, 107, 110, 113, 115, 123, 124, 127, 129,130, 134, 141, 170-172, 193, 204, 225, 226, 230, 263, and265.