Table 2.

Morphology-associated and other cell wall proteins

ProteinGeneLocationCommentsaReference(s)
Morphology associated
 4C12 antigen (180 kDa, 260 kDa)HyphaeStructural protein? 59, 62, 122, 128, 160, 327
 3D9 antigen (110–170 kDa)HyphaeStructural protein? 324, 325
 DC3:H10 antigenHyphaePresent in complex with other proteins 87, 300
 Hwp1p (34 kDa) HWP1 HyphaeN-terminal signal sequence, tandem repeats, C terminus ST rich 513
 Hyr1p (deduced 94 kDa) HYR1 HyphaeN-terminal signal sequence, C terminus ST rich, GPI anchor sequence 16
 Cell wall protein (30 kDa)Hyphal cell wall, yeast?Probable posttranslation regulation of location 5
 MAb determinants 106
  Yeast cell (68, 82, 96, 104 kDa)Yeast cells and early germ tubesProteins have one or two common epitopes
  Hyphae (104, 117 kDa)Germ tubes and hyphal tipProteins have one or two common epitopes
Other
 Hsp70 (70 kDa) SSA1 (HSP70),SSA2 Yeast cells, hyphaeChaperone?, translocation?; immunogenic, Ab protective? 278, 294, 303
 Hsp90
  47-kDa fragment HSP90 Yeast cells, hyphae?hsp90 degradation product, immunogenic, Ab protective 331, 334, 335, 337-340, 342, 532
 Enolase (48 kDa) ENO1-2 Yeast cells, hyphaeBinds to glucan, internal cell wall, lacks N-terminal signal sequence, N terminus blocked, immunogenic, antigen and Abs may be diagnostic, Ab protective? 8, 143, 177, 219, 221, 330, 356, 420, 520-522,556, 558, 564
 Phosphoglycerate kinase (40 kDa) PGK1 Yeast cells, hyphaeLacks N-terminal signal sequence, enzymatic activity? immunogenic 6
 GAPDH (33 kDa) TDH1 Yeast cells, hyphaeEnzymatic activity, immunogenic 161
 ADH ADH1? Cell wall?Fibronectin binding? immunogenic 27, 406, 489
 Als1p ALS1 Cell wall?N-terminal signal sequence, variable tandem repeat, GPI-anchor sequence, member family 212, 473
  • a Abbreviations: S, serine; T, threonine; Ab, antibody.