Table 19.

Common sequence motifs localized between TMS2 and TMS3 in the 17 families of the MFSa

FamilyPredominant residue at position:
No.Name1 G2 [RKPATY]3 L4 [GAS]5 [DN]6 [RK]7 [FY]8 G9 R10 [RK]11 [RKP]12 [LIVGST]13 [LIM]
1SPGXLGNRFGRRXXL
2DHA14GRLADRFGRKRXL
3DHA12GXLSDRFGRRPVL
4OPAGTLGDHYNPRRXL
5OHSGLLSDKLGLRKHL
6MHSGAYGDRYGRKKGL
7FGHSKRYSYKAGIXXGL
8NNPGPLTDRFGPRXXX
9PHSVAFIDTIGRKPIQ
10NHSb GIIAVQMARRTCI
11OFANKWFDKRGLASGI
12SHSGAMADKYGRKPVM
13MCPSXLVNKYGSRPVM
14ACSGYLLDKKGAKKVI
15UMFARLSDIFGRLXLF
16AAHSGPLADRFGRKRVL
17CPXXLXQRXGXERSL
Σc 1111111114131115913111114
  • a The residue indicated is the one present in the largest number of proteins in the indicated family at the position specified. In some cases two similar residues (e.g., S and T, or R and K) were present with the same frequency. One of these residues was then arbitrarily selected. An X indicates that no single residue predominated at that position.

  • b Only one of the two members of this family was used to provide the sequence shown. The other protein exhibited gaps in the region of this motif.

  • c The numbers of families that exhibit the residue(s) indicated in the “consensus” sequence at the top of the table are indicated.