Table 21.

Systematic classification of MFS permeases

TC no.Name or descriptionaSourceOrganismAccession no.Data- baseb
2.1.1SP family (family 1)
 2.1.1.1Galactose:H+symporterBacteriaGalP of Escherichia coli P37021 SP
 2.1.1.2Arabinose:H+ symporterBacteriaAraE of Escherichia coli P09830 SP
 2.1.1.3Xylose:H+ symporterBacteriaXylE ofEscherichia coli P09098 SP
 2.1.1.4Glucose uniporterBacteriaGlf of Zymomonas mobilis P21906 SP
 2.1.1.5Hexose uniporterYeastsHxtO ofSaccharomyces cerevisiae P43581 SP
 2.1.1.6Galactose uniporterYeastsGal2 ofSaccharomyces cerevisiae P13181 SP
 2.1.1.7Quinate:H+ symporterFungiQay ofNeurospora crassa P11636 SP
 2.1.1.8Myoinositol:H+ symporterYeastsITR1 of Saccharomyces cerevisiae P30605 SP
 2.1.1.9Lactose:H+ symporterYeastsLacP ofKluyveromyces lactis P07921 SP
 2.1.1.10Maltose:H+ symporterYeastsMAL6 ofSaccharomyces cerevisiae P15685 SP
 2.1.1.11α-Glucoside:H+symporterYeastsαGlc permease of Saccharomyces cerevisiae S59368 PIR
 2.1.1.12Glucose uniporterAnimalsGtr3 of Rattus norvegicus Q07647 SP
 2.1.1.13Fructose uniporterAnimalsFtr of Homo sapiens U11843 GB
 2.1.1.14Hexose:H+symporterPlantsHup1 of Chlorella kessleri P15686 SP
 2.1.1.15Synaptic vesicle neurotransmitter transporterAnimalsSYV2 of Rattus norvegicus Q02563 SP
 2.1.1.16Organic cation transporterAnimalsOca of Rattus norvegicus X78855 GB
 2.1.1.17Glucose transporterProtistsTh2A of Trypanosoma brucei Q06222 SP
2.1.2DHA14 family (family 2)
 2.1.2.1ActinorhordinGram-positive bacteriaActVa ofStreptomyces coelicolor X58833 GB
 2.1.2.2CephamycinGram-positive bacteriaCmcT ofNocardia lactamdurans Q04733 SP
 2.1.2.3LincomycinGram-positive bacteriaLmrA ofStreptomyces lincolnensis X59926 GB
 2.1.2.4MethylenomycinGram-positive bacteriaMmrB ofBacillus subtilis Q00538 SP
 2.1.2.5PuromycinGram-positive bacteriaPur8 ofStreptomyces lipmanii X76855 GB
 2.1.2.6TetracenomycinGram-positive bacteriaTemA ofStreptomyces glaucescens M80674 GB
 2.1.2.7Bicyclomycin, sulfathiazole, etc.Gram-negative bacteriaBcr of Escherichia coli JN0659PIR
 2.1.2.8Fluoroquinolones, acriflavin, chloramphenicol, ethidium bromide, etc.Gram-positive bacteriaBlt ofBacillus subtilis L32599 GB
 2.1.2.9Hydrophobic uncouplers (e.g., CCCP)Gram-negative bacteriaEmrD ofEscherichia coli P31442 SP
 2.1.2.10Daunomycin, ethidium bromideGram-positive bacteriaLmrP of Lactococcus lactis X89779 GB
 2.1.2.11Benomyl, cycloheximide, methotrexate, etc.YeastsCaMDR1 of Candida albicans P28873 SP
 2.1.2.12Doxorubicin, ethidium bromide, rhodamine-6-GMammalsVMAT1 of Rattus norvegicus M97380 GB
 2.1.2.13AmilorideYeastsCar1 ofSchizosaccharomyces cerevisiae P33532 SP
 2.1.2.14CycloheximideYeastsCyhR of Candida maltosa P32071 SP
 2.1.2.15ChloramphenicolBacteriaCmlA ofPseudomonas aeruginosa P32482 SP
 2.1.2.16TetracyclineBacteriaTetA of Escherichia coli X00006 GB
 2.1.2.17AcetylcholineAnimalsUnc17 ofCaenorhabditis elegans P34711 SP
2.1.3DHA12 family (family 3)
 2.1.3.1Aminotriazole, 4-nitroquinoline-N-oxideYeastsAtr1 ofSaccharomyces cerevisiae Z49210 GB
 2.1.3.2CCCP, nalidixic acid, organomercurials, etc.Gram-negative bacteriaEmrB of Escherichia coli P27304 SP
 2.1.3.3Acriflavin, ethidium bromide, fluoroquinolonesGram-positive bacteriaLfrA ofMycobacterium smegmatis U40487 GB
 2.1.3.4Mono- and divalent organocationsGram-positive bacteriaQacA ofStaphylococcus aureus X56628 GB
 2.1.3.5Pristinamycin I and II, rifamycinGram-positive bacteriaPtr of Streptomyces pristinaespiralis X84072 GB
 2.1.3.6TetracyclineBacteriaTetK of Staphylococcus aureus M16217 GB
2.1.4OPA family (family 4)
 2.1.4.1Hexose-phosphate:PiantiporterBacteriaUhpC of Escherichia coli P09836 SP
 2.1.4.2Phosphoglycerate:PiantiporterBacteriaPgtP of Salmonella typhimurium P12681 SP
 2.1.4.3Glycerol-phosphate:PiantiporterBacteriaGlpT of Escherichia coli P08194 SP
2.1.5OHS family (family 5)
 2.1.5.1Lactose:H+ symporterBacteriaLacY of Escherichia coli P02920 SP
 2.1.5.2Raffinose:H+ symporterBacteriaRafB of Escherichia coli P16552 SP
 2.1.5.3Sucrose:H+ symporterBacteriaCscB of Escherichia coli P30000 SP
2.1.6MHS family (family 6)
 2.1.6.1Citrate:H+symporterBacteriaCit of Escherichia coli P07860 SP
 2.1.6.2α-Ketoglutarate:H+symporterBacteriaKgtP of Escherichia coli P17448 SP
 2.1.6.3Dicarboxylate:H+symporterBacteriaPcaT of Pseudomonas putida U48776 GB
 2.1.6.4(Proline/betaine):(H+/Na+) symporterBacteriaProP of Escherichia coli P30848 SP
 2.1.6.54-Methyl-o-phthalate:H+symporterBacteriaMopB of Burkholderia cepacia U29532 GB
2.1.7FHS family (family 7)
 2.1.7.1L-Fucose:H+ symporterBacteriaFucP of Escherichia coli P11551 SP
 2.1.7.2Glucose/galactose permeaseBacteriaGgp ofBrucella abortus U43785 GB
2.1.8NNP family (family 8)
 2.1.8.1Nitrite extrusion permeaseBacteriaNarK of Escherichia coli P10903 SP
 2.1.8.2Nitrate uptake permeaseBacteriaNasA ofBacillus subtilis P42432 SP
2.1.9PHS family (family 9)
 2.1.9.1Pi uptake permeaseYeastsPh84 ofSaccharomyces cerevisiae P25297 SP
 2.1.9.2Pi uptake permeaseFungiPho-5 ofNeurospora crassa L36127 GB
 2.1.9.3Piuptake permeasePlantsPT1 of Solanum tuberosum X98890 GB
2.1.10NHS family (family 10)
 2.1.10.1Nucleoside permeaseBacteriaNupG ofEscherichia coli P09452 SP
 2.1.10.2Xanthosine permeaseBacteriaXapB of Escherichia coli P45562 SP
2.1.11OFA family (family 11)
 2.1.11.1The oxalate:formate antiporterBacteriaOxlT of Escherichia coli U40075 GB
2.1.12SHS family (family 12)
 2.1.12.1The sialic acid permeaseBacteriaNanT ofEscherichia coli P41036 SP
2.1.13MCP family (family 13)
 2.1.13.1The monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux permeaseAnimals, yeasts, fungiMot-1 of Homo sapiens A55568 PIR
2.1.14ACS family (family 14)
 2.1.14.1Glucarate permeaseBacteriaGudT ofBacillus subtilis P42237 SP
 2.1.14.2Hexuronate permeaseBacteriaExuT of Escherichia coli P42609 SP
 2.1.14.3Putative tartrate permeaseBacteriaTtuB ofAgrobacterium vitis U32375 GB
 2.1.14.4Allantoate permeaseYeastsDal5 of Saccharomyces cerevisiae P15365 SP
 2.1.14.5Phthalate permeaseBacteriaPht1 of Pseudomonas putida Q05181 SP
 2.1.14.6Na:PisymporterAnimalsNpt1 of Mus musculus X77241 GB
2.1.15AAS family (family 15)
 2.1.15.14-Hydroxybenzoate (protocatachuate) permeaseBacteriaPcaK of Pseudomonas putida U10895 GB
 2.1.15.23-Hydroxyphenyl propionate permeaseBacteriaMhpT of Escherichia coli X97543 GB
 2.1.15.32,4-Dichlorophenoxy-acetate permeaseBacteriaTfdK of Ralstonia eutropha U16782 GB
2.1.16UMF family (family 16)
 2.1.16.1Permease of unknown specificityYeastsYkr106w of Saccharomyces cerevisiae P36173 SP
2.1.17CP family (family 17)
 2.1.17.1Cyanate transport systemBacteriaCynX ofEscherichia coli P17583 SP
  • a CCCP, carbonyl cyanidem-chlorophenylhydrazone; Pi, inorganic phosphate.

  • b See Table 3, footnote b.