Table 21.

Systematic classification of MFS permeases

TC no.Name or descriptionaSourceOrganismAccession no.Data- baseb
2.1.1SP family (family 1)
 2.1.1.1Galactose:H+symporterBacteriaGalP of Escherichia coliP37021SP
 2.1.1.2Arabinose:H+ symporterBacteriaAraE of Escherichia coliP09830SP
 2.1.1.3Xylose:H+ symporterBacteriaXylE ofEscherichia coliP09098SP
 2.1.1.4Glucose uniporterBacteriaGlf of Zymomonas mobilisP21906SP
 2.1.1.5Hexose uniporterYeastsHxtO ofSaccharomyces cerevisiaeP43581SP
 2.1.1.6Galactose uniporterYeastsGal2 ofSaccharomyces cerevisiaeP13181SP
 2.1.1.7Quinate:H+ symporterFungiQay ofNeurospora crassaP11636SP
 2.1.1.8Myoinositol:H+ symporterYeastsITR1 of Saccharomyces cerevisiaeP30605SP
 2.1.1.9Lactose:H+ symporterYeastsLacP ofKluyveromyces lactisP07921SP
 2.1.1.10Maltose:H+ symporterYeastsMAL6 ofSaccharomyces cerevisiaeP15685SP
 2.1.1.11α-Glucoside:H+symporterYeastsαGlc permease of Saccharomyces cerevisiaeS59368PIR
 2.1.1.12Glucose uniporterAnimalsGtr3 of Rattus norvegicusQ07647SP
 2.1.1.13Fructose uniporterAnimalsFtr of Homo sapiensU11843GB
 2.1.1.14Hexose:H+symporterPlantsHup1 of Chlorella kessleriP15686SP
 2.1.1.15Synaptic vesicle neurotransmitter transporterAnimalsSYV2 of Rattus norvegicusQ02563SP
 2.1.1.16Organic cation transporterAnimalsOca of Rattus norvegicusX78855GB
 2.1.1.17Glucose transporterProtistsTh2A of Trypanosoma bruceiQ06222SP
2.1.2DHA14 family (family 2)
 2.1.2.1ActinorhordinGram-positive bacteriaActVa ofStreptomyces coelicolorX58833GB
 2.1.2.2CephamycinGram-positive bacteriaCmcT ofNocardia lactamduransQ04733SP
 2.1.2.3LincomycinGram-positive bacteriaLmrA ofStreptomyces lincolnensisX59926GB
 2.1.2.4MethylenomycinGram-positive bacteriaMmrB ofBacillus subtilisQ00538SP
 2.1.2.5PuromycinGram-positive bacteriaPur8 ofStreptomyces lipmaniiX76855GB
 2.1.2.6TetracenomycinGram-positive bacteriaTemA ofStreptomyces glaucescensM80674GB
 2.1.2.7Bicyclomycin, sulfathiazole, etc.Gram-negative bacteriaBcr of Escherichia coliJN0659PIR
 2.1.2.8Fluoroquinolones, acriflavin, chloramphenicol, ethidium bromide, etc.Gram-positive bacteriaBlt ofBacillus subtilisL32599GB
 2.1.2.9Hydrophobic uncouplers (e.g., CCCP)Gram-negative bacteriaEmrD ofEscherichia coliP31442SP
 2.1.2.10Daunomycin, ethidium bromideGram-positive bacteriaLmrP of Lactococcus lactisX89779GB
 2.1.2.11Benomyl, cycloheximide, methotrexate, etc.YeastsCaMDR1 of Candida albicansP28873SP
 2.1.2.12Doxorubicin, ethidium bromide, rhodamine-6-GMammalsVMAT1 of Rattus norvegicusM97380GB
 2.1.2.13AmilorideYeastsCar1 ofSchizosaccharomyces cerevisiaeP33532SP
 2.1.2.14CycloheximideYeastsCyhR of Candida maltosaP32071SP
 2.1.2.15ChloramphenicolBacteriaCmlA ofPseudomonas aeruginosaP32482SP
 2.1.2.16TetracyclineBacteriaTetA of Escherichia coliX00006GB
 2.1.2.17AcetylcholineAnimalsUnc17 ofCaenorhabditis elegansP34711SP
2.1.3DHA12 family (family 3)
 2.1.3.1Aminotriazole, 4-nitroquinoline-N-oxideYeastsAtr1 ofSaccharomyces cerevisiaeZ49210GB
 2.1.3.2CCCP, nalidixic acid, organomercurials, etc.Gram-negative bacteriaEmrB of Escherichia coliP27304SP
 2.1.3.3Acriflavin, ethidium bromide, fluoroquinolonesGram-positive bacteriaLfrA ofMycobacterium smegmatisU40487GB
 2.1.3.4Mono- and divalent organocationsGram-positive bacteriaQacA ofStaphylococcus aureusX56628GB
 2.1.3.5Pristinamycin I and II, rifamycinGram-positive bacteriaPtr of Streptomyces pristinaespiralisX84072GB
 2.1.3.6TetracyclineBacteriaTetK of Staphylococcus aureusM16217GB
2.1.4OPA family (family 4)
 2.1.4.1Hexose-phosphate:PiantiporterBacteriaUhpC of Escherichia coliP09836SP
 2.1.4.2Phosphoglycerate:PiantiporterBacteriaPgtP of Salmonella typhimuriumP12681SP
 2.1.4.3Glycerol-phosphate:PiantiporterBacteriaGlpT of Escherichia coliP08194SP
2.1.5OHS family (family 5)
 2.1.5.1Lactose:H+ symporterBacteriaLacY of Escherichia coliP02920SP
 2.1.5.2Raffinose:H+ symporterBacteriaRafB of Escherichia coliP16552SP
 2.1.5.3Sucrose:H+ symporterBacteriaCscB of Escherichia coliP30000SP
2.1.6MHS family (family 6)
 2.1.6.1Citrate:H+symporterBacteriaCit of Escherichia coliP07860SP
 2.1.6.2α-Ketoglutarate:H+symporterBacteriaKgtP of Escherichia coliP17448SP
 2.1.6.3Dicarboxylate:H+symporterBacteriaPcaT of Pseudomonas putidaU48776GB
 2.1.6.4(Proline/betaine):(H+/Na+) symporterBacteriaProP of Escherichia coliP30848SP
 2.1.6.54-Methyl-o-phthalate:H+symporterBacteriaMopB of Burkholderia cepaciaU29532GB
2.1.7FHS family (family 7)
 2.1.7.1L-Fucose:H+ symporterBacteriaFucP of Escherichia coliP11551SP
 2.1.7.2Glucose/galactose permeaseBacteriaGgp ofBrucella abortusU43785GB
2.1.8NNP family (family 8)
 2.1.8.1Nitrite extrusion permeaseBacteriaNarK of Escherichia coliP10903SP
 2.1.8.2Nitrate uptake permeaseBacteriaNasA ofBacillus subtilisP42432SP
2.1.9PHS family (family 9)
 2.1.9.1Pi uptake permeaseYeastsPh84 ofSaccharomyces cerevisiaeP25297SP
 2.1.9.2Pi uptake permeaseFungiPho-5 ofNeurospora crassaL36127GB
 2.1.9.3Piuptake permeasePlantsPT1 of Solanum tuberosumX98890GB
2.1.10NHS family (family 10)
 2.1.10.1Nucleoside permeaseBacteriaNupG ofEscherichia coliP09452SP
 2.1.10.2Xanthosine permeaseBacteriaXapB of Escherichia coliP45562SP
2.1.11OFA family (family 11)
 2.1.11.1The oxalate:formate antiporterBacteriaOxlT of Escherichia coliU40075GB
2.1.12SHS family (family 12)
 2.1.12.1The sialic acid permeaseBacteriaNanT ofEscherichia coliP41036SP
2.1.13MCP family (family 13)
 2.1.13.1The monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux permeaseAnimals, yeasts, fungiMot-1 of Homo sapiensA55568PIR
2.1.14ACS family (family 14)
 2.1.14.1Glucarate permeaseBacteriaGudT ofBacillus subtilisP42237SP
 2.1.14.2Hexuronate permeaseBacteriaExuT of Escherichia coliP42609SP
 2.1.14.3Putative tartrate permeaseBacteriaTtuB ofAgrobacterium vitisU32375GB
 2.1.14.4Allantoate permeaseYeastsDal5 of Saccharomyces cerevisiaeP15365SP
 2.1.14.5Phthalate permeaseBacteriaPht1 of Pseudomonas putidaQ05181SP
 2.1.14.6Na:PisymporterAnimalsNpt1 of Mus musculusX77241GB
2.1.15AAS family (family 15)
 2.1.15.14-Hydroxybenzoate (protocatachuate) permeaseBacteriaPcaK of Pseudomonas putidaU10895GB
 2.1.15.23-Hydroxyphenyl propionate permeaseBacteriaMhpT of Escherichia coliX97543GB
 2.1.15.32,4-Dichlorophenoxy-acetate permeaseBacteriaTfdK of Ralstonia eutrophaU16782GB
2.1.16UMF family (family 16)
 2.1.16.1Permease of unknown specificityYeastsYkr106w of Saccharomyces cerevisiaeP36173SP
2.1.17CP family (family 17)
 2.1.17.1Cyanate transport systemBacteriaCynX ofEscherichia coliP17583SP
  • a CCCP, carbonyl cyanidem-chlorophenylhydrazone; Pi, inorganic phosphate.

  • b See Table 3, footnote b.