Table 18.

Signature sequences for 16 of the 17 families of the MFS as well as for the related POT family

FamilySignature sequence
No.Name
1SPa [LIVFYW]-x-[SAGTN]-E-[LIVFMTN]-x5-[RS]-[GRKYA]-x7-[LIVMFST]-x-[LIVWF]-x2-G-x-[LIVFM]-[LIVGTFY]
2DHA14b W-[RPSEGH]-[WYSA]-[LIVCA]-[FL]-[LIVWYF]-[LIVA]-[NAPY]-[LIVMS]-[PI]-[LIVMATF]-x1,3-[LIVANGS][LIVMFCAP]-[LIVAFG]-[LIMAGY]
3DHA12b [TINFYKAS]-[GYLIVTAS]-x2-[LIVFAP]-x2-[LIFSMWP]-[LIVFWS]-x-[GAM]-x2-[ANSTV]-[DANR]-x2-[GEP]-[RYK][KRHTPW]-x-[LIVMPS]-[LIVMY]-x2-[GATSCF]-x2-[LIVGATF]-x2-[LIVCAT]-x2-[LIVFMA]-[LIVMGPSA]x-[LIVMCAG]-[LIVCATF]-[NVPATSG]
4OPAR-[GI]-x3-[GAST]-[LIVFA]-W-[NS]-x-[SACN]-[HAG]-[NS]-[LIVT]-G-[GN]-[GAI]
5OHSD-[KR]-L-G-L-[RK]-K-x-L-[LIV]-W-x2-[ST]-x2-L-[LIV]-x2-[AG]-P-F
6MHSP-[LIV]-G-[GAS]-x-[LIVF]-[LIVFM]-G-x3-D-[RK]-x-G-R
7FGHSA-[GAP]-x4-[RK]-x-S-x3-[GT]-[LIVT]3-[GA]-L-x-[LIV]
8NNP[FYK]-x3-[ILQRK]-x-[GA]-x-[VASK]-x-[GASN]-[LIVFQ]-x1,2-G-x-G-[NIM]-x-G-[GVTA]
9PHSN-x-G-P-x5-[LIV]-[LIVY]-[PS]-[AGS]-E-x-[FS]-[PA]-[AT]-x2-R-[SG]-x3-G-[LIV]-S-A-x2-G-K-x-G
10NHSL-G-L-D-A-F-x-L-F-K-N
11OFAY-x6-[AC]-x-[KR]-W-[FY]-[PQ]-[DE]-x2-G-L-x-[STG]-[GA]-x4-[GS]-[FY]-G-x-G
12SHSE-x-W-P-x5-K-A-x6-G-x2-V-G-x3-A-A
13MCPG-[LIVCF]-[GS]-x-[ASG]-x4-[PA]-x-[LIVT]-x5-[YW]-F-x2-[RKL]2-x-[LIVTM]-A-x-[GAS]-x4-G
14ACSc
15UMFG-[LIVM]-[LIV]-L-[LIVFM]-[TG]-x4-[LIVC]-[LIV]-L-[LIV]-P
16AAHSS-[FIA]-[GAT]-[LIV]-x-G-x3-G-[AG]-[LIVF]-x2-[GS]-x-[ALIT]-[AC]-D-[RK]
17CPR-[TS]-[LV]-x3-L-[LV]-[LI]2-x2-G-x3-R
18POT[LIVT]-[LIVGAS]-[LIVFCA]-[GA]-[TASNY]-G-[GLM]-[LIVMF]-[KRN]-[APS]-[SCN]-[LIVP]-[LIVSA]-X-[LIVMF][LIVMAG]
  • a The “signature sequence” of the SP family (family 1) is based on those representative proteins depicted in Fig. 3. It is therefore not a true signature sequence.

  • b The signature sequences of the DHA14 and DHA12 families are based on the multiple-sequence alignments published by Paulsen et al. (60).

  • c No family-specific signature sequence could be derived for the ACS family.