Family | Signature sequence | |
---|---|---|

No. | Name | |

1 | SP^{a} | [LIVFYW]-x-[SAGTN]-E-[LIVFMTN]-x_{5}-[RS]-[GRKYA]-x_{7}-[LIVMFST]-x-[LIVWF]-x_{2}-G-x-[LIVFM]-[LIVGTFY] |

2 | DHA14^{b} | W-[RPSEGH]-[WYSA]-[LIVCA]-[FL]-[LIVWYF]-[LIVA]-[NAPY]-[LIVMS]-[PI]-[LIVMATF]-x_{1,3}-[LIVANGS][LIVMFCAP]-[LIVAFG]-[LIMAGY] |

3 | DHA12^{b} | [TINFYKAS]-[GYLIVTAS]-x_{2}-[LIVFAP]-x_{2}-[LIFSMWP]-[LIVFWS]-x-[GAM]-x_{2}-[ANSTV]-[DANR]-x_{2}-[GEP]-[RYK][KRHTPW]-x-[LIVMPS]-[LIVMY]-x_{2}-[GATSCF]-x_{2}-[LIVGATF]-x_{2}-[LIVCAT]-x_{2}-[LIVFMA]-[LIVMGPSA]x-[LIVMCAG]-[LIVCATF]-[NVPATSG] |

4 | OPA | R-[GI]-x_{3}-[GAST]-[LIVFA]-W-[NS]-x-[SACN]-[HAG]-[NS]-[LIVT]-G-[GN]-[GAI] |

5 | OHS | D-[KR]-L-G-L-[RK]-K-x-L-[LIV]-W-x_{2}-[ST]-x_{2}-L-[LIV]-x_{2}-[AG]-P-F |

6 | MHS | P-[LIV]-G-[GAS]-x-[LIVF]-[LIVFM]-G-x_{3}-D-[RK]-x-G-R |

7 | FGHS | A-[GAP]-x_{4}-[RK]-x-S-x_{3}-[GT]-[LIVT]_{3}-[GA]-L-x-[LIV] |

8 | NNP | [FYK]-x_{3}-[ILQRK]-x-[GA]-x-[VASK]-x-[GASN]-[LIVFQ]-x_{1,2}-G-x-G-[NIM]-x-G-[GVTA] |

9 | PHS | N-x-G-P-x_{5}-[LIV]-[LIVY]-[PS]-[AGS]-E-x-[FS]-[PA]-[AT]-x_{2}-R-[SG]-x_{3}-G-[LIV]-S-A-x_{2}-G-K-x-G |

10 | NHS | L-G-L-D-A-F-x-L-F-K-N |

11 | OFA | Y-x_{6}-[AC]-x-[KR]-W-[FY]-[PQ]-[DE]-x_{2}-G-L-x-[STG]-[GA]-x_{4}-[GS]-[FY]-G-x-G |

12 | SHS | E-x-W-P-x_{5}-K-A-x_{6}-G-x_{2}-V-G-x_{3}-A-A |

13 | MCP | G-[LIVCF]-[GS]-x-[ASG]-x_{4}-[PA]-x-[LIVT]-x_{5}-[YW]-F-x_{2}-[RKL]_{2}-x-[LIVTM]-A-x-[GAS]-x_{4}-G |

14 | ACS^{c} | |

15 | UMF | G-[LIVM]-[LIV]-L-[LIVFM]-[TG]-x_{4}-[LIVC]-[LIV]-L-[LIV]-P |

16 | AAHS | S-[FIA]-[GAT]-[LIV]-x-G-x_{3}-G-[AG]-[LIVF]-x_{2}-[GS]-x-[ALIT]-[AC]-D-[RK] |

17 | CP | R-[TS]-[LV]-x_{3}-L-[LV]-[LI]_{2}-x_{2}-G-x_{3}-R |

18 | POT | [LIVT]-[LIVGAS]-[LIVFCA]-[GA]-[TASNY]-G-[GLM]-[LIVMF]-[KRN]-[APS]-[SCN]-[LIVP]-[LIVSA]-X-[LIVMF][LIVMAG] |

↵a The “signature sequence” of the SP family (family 1) is based on those representative proteins depicted in Fig. 3. It is therefore not a true signature sequence.

↵b The signature sequences of the DHA14 and DHA12 families are based on the multiple-sequence alignments published by Paulsen et al. (60).

↵c No family-specific signature sequence could be derived for the ACS family.