Table 2.

M proteins and their ligands

M proteinStrainReference(s)M typeExperimentally demonstrated ligands
Class I Emm
 M1 (Emm1)AP1 8 1Albumin (712), fibrinogen (8, 712), IgG (712), kininogen (33)
 M1.0 (Emm1.0)CS130 297,306 1
 M1.1 (Emm1.1)CS190 306 1
 M1.2 (Emm1.2)T1/29/58 306 1
 M3 (Emm3)4/55 416, 666 3Albumin (666), fibrinogen (666), fibronectin (666)
 M5 (Emm5)Manfredo 552 5Fibrinogen (851), factor H (445), FHL-1 (445)
 M5.8193NCTC 8193 849 5Fibrinogen (849)
 M6 (Emm6.1)D471 346 6CD46 (596), factor H (354), FHL-1 (445), fibrinogen (851), kininogen (33)
 M12 (Emm12)CS24 671 12Albumin (666), IgG (666)
 M18.1 (Emm18.1)87-282 137 18
 M24 (Emm24)Vaughn 560 24Fibrinogen (850)
 M41 (Emm41)71-710 632 41Plasminogen (112)
 M52 (Emm52)71-719 632 52Plasminogen (112)
 EmmL55 (Emm55)A928 77 55Albumin (77), fibrinogen (77), IgG (77)
 M57 (Emm57)A995 515 57
Class II Emm
 Emm2 (EmmL2.1)T2/MR 51 2
 Emm4 (Arp4)AP4 232 4C4BP (780), IgA (5), IgG (753)
 Emm971-683 635 9IgG (635)
 EmmL15 (Emm15)EF1949 415 15
 Emm22 (Sir22)AL168 754 22C4BP (780), IgA (753), IgG (753)
 Emm28 (Sir28)AL368 488,753 28IgA (753), IgG (753)
 Emm49 (EmmL49)CS101 295 49Albumin (229), IgG (229)
 Emm50 (EmmL50)B514 877 50IgG (877)
 Emm53 (PAM)M53 42 53Plasminogen (42,112)
 Emm60 (Arp60)AW43 320 60C4BP (780), IgA (320), IgG (486)
 Emm64/1464/14 75 NTIgG (75)
Mrp
 Mrp4AP4 607 4Fibrinogen (607), IgG (607)
 Mrp84025 447 8Fibrinogen (447), IgG (447)
 Mrp971-683 447 9Fibrinogen (447), IgG (447)
 Mrp1371-686 447 13Fibrinogen (447), IgG (447)
 Mrp15EF1949 415 15
 Mrp22AL168 754 22Fibrinogen (753), IgG (753)
 Mrp28AL368 753 28Fibrinogen (753), IgG (753)
 Mrp49 (FcrA49)CS101 636 49Fibrinogen (447), IgG (636)
 Mrp50B514 877 50IgG (877)
 Mrp60AW43 753 60Fibrinogen (753), IgG (753)
 Mrp76 (FcrA76)CS110 313 76Fibrinogen (607), IgG (607)
 Mrp64/14 (Fcr64/14)64/14 75 NTFibrinogen (447), IgG (75, 447)
Enn (Emm Iib)
 Enn2 (EmmL2.2)T2/MR 51 2IgA (51)
 Enn4AP4 381 4IgA (391)
 Enn15EF1949 415 15
 Enn22AL168 754 22
 Enn49 (EnnX)CS101 295 49
 Enn50B514 877 50IgA (877)
Mosaic Enn
 Protein HAP1 273 1Albumin (229), C4BP (393), IgG (7), fibronectin (230), MHC-II (8), N-CAM (230)
 Enn5.8193NCTC8193 849 5IgG (849)
 Enn64/1464/14 635 NTIgG3 (635)