Table 1.

Cdc42p potential regulators and effectorsa

Regulator or effectorS. cerevisiaeS. pombeDrosophilaC. elegansMammals
Regulators
 GEFsCdc24Scd1Drt-GEF?Unc-73?Dbl
DRho-GEF?Bcr
DRho-GEF2?Abr
Dbs
Tiam-1
Ect2
Ost
FGD1
Brx
 GDIsRdi1???Rho-GDI
 GAPsBem3?RnRac-GAP?Ce-GAP?Cdc42GAP/p50rhoGAP
Rga1/Dbm1Bcr
Rga2Abr
p190GAP
n-Chimaerin
3BP-1
Graf
RalBP1/RLIP76/RIP1
MgcRacGAP
PARG1
myr5
CdGAP
Effectors
 KinasesSte20Pak1/Shk1DPAKCe-PAKPAK1
Cla4Pak2cMEKKsPAK2
Skm1PAK3
ACK-1, ACK-2
MLK3
MEKKs
 OthersBni1, Bnr1Fus1, Cdc12? diaphanous ?Formins, p140mDia
Iqg1/Cyk1???IQGAPs
Bee1/Las17???WASPs
Gic1, Gic2????
Zds1, Zds2????
Bem4/Rom7????
????pp70-S6 kinase
  • a Proteins that have in vitro Cdc42p GEF, GAP, or GDI activity or that contain structurally homologous domains are listed. See the text for details on potential in vivo functions and complete references.