Table 1.

Hydrolytic enzymes and proteins with cell wall and extracellular targets

EnzymeGeneLocationCommentsReference(s)
Cell wall substrates
 Exo-β-(1,3)-glucanase EXG(XOG1)Cell wall, extracellularCell wall morphogenesis 75, 307, 308, 361, 387, 428, 429
 β-1,3-glucan transferase BGL2 Cell wallCell wall metabolism 122, 178, 196, 466, 471
 Chitinase CHT1-3 Periplasm, cell wall, extracellularHydrolytic enzyme, cell wall morphogenesis 141, 170, 346, 347
 β-N-acetylglucosaminidase HEX1 Periplasmic, extracellularHydrolytic enzyme, virulence factor? 55,221, 365, 426, 519
 TransglutaminaseCell wallCovalent cross-links? 456
Extracellular substrates
 Secreted aspartyl proteinase SAP1-9 Extracellular, cell surfacePutative virulence factor, gene expression condition dependent 1, 3, 18, 31, 84, 99-101, 109, 147, 157, 205,206, 214, 215, 232, 233, 277, 348-350, 353, 359, 370, 372, 378, 379,381, 397, 433-435, 441, 445-448, 450, 451, 509-511, 514, 515, 552,570, 574
 Phospholipase
  Phospholipase ACell wall, surface, extracellularHydrolytic enzyme 23, 174, 425, 427
  Phospholipase B PLB1 ExtracellularHydrolytic enzyme, putative virulence factor 19, 217, 473, 533
  Phospholipase CExtracellularHydrolytic enzyme 425,427
  LysophospholipaseCell wall, surface, extracellularHydrolytic enzyme 19, 23, 174, 355, 425,427, 533
  Lysophospholipase-transacylaseExtracellularHydrolytic enzyme, putative virulence factor 19, 217, 533,534
 EsteraseExtracellularHydrolytic enzyme 56, 419, 449, 551
 GlucoamylaseExtracellularHydrolytic enzyme 82
 Hemolytic factorCell wall, extracellularHydrolytic enzyme 317
 Acid phosphatasePeriplasmic, surfaceHydrolytic enzyme 78, 105, 391, 547
 Lipase LIP1 ExtracellularHydrolytic enzyme 148
 HyaluronidaseExtracellularHydrolytic enzyme, virulence factor? 499, 500
 Chondroitan sulfataseExtracellularHydrolytic enzyme, virulence factor? 499, 500
 MetallopeptidaseCell wall, extracellular?Hydrolytic enzyme 120, 121
 TrehalaseCell wall, extracellularHydrolytic enzyme 362,454