Table 1.

Hydrolytic enzymes and proteins with cell wall and extracellular targets

EnzymeGeneLocationCommentsReference(s)
Cell wall substrates
 Exo-β-(1,3)-glucanaseEXG(XOG1)Cell wall, extracellularCell wall morphogenesis75, 307, 308, 361, 387, 428, 429
 β-1,3-glucan transferaseBGL2Cell wallCell wall metabolism122, 178, 196, 466, 471
 ChitinaseCHT1-3Periplasm, cell wall, extracellularHydrolytic enzyme, cell wall morphogenesis141, 170, 346, 347
 β-N-acetylglucosaminidaseHEX1Periplasmic, extracellularHydrolytic enzyme, virulence factor?55, 221, 365, 426, 519
 TransglutaminaseCell wallCovalent cross-links?456
Extracellular substrates
 Secreted aspartyl proteinaseSAP1-9Extracellular, cell surfacePutative virulence factor, gene expression condition dependent1, 3, 18, 31, 84, 99-101, 109, 147, 157, 205, 206, 214, 215, 232, 233, 277, 348-350, 353, 359, 370, 372, 378, 379, 381, 397, 433-435, 441, 445-448, 450, 451, 509-511, 514, 515, 552, 570, 574
 Phospholipase
  Phospholipase ACell wall, surface, extracellularHydrolytic enzyme23, 174, 425, 427
  Phospholipase BPLB1ExtracellularHydrolytic enzyme, putative virulence factor19, 217, 473, 533
  Phospholipase CExtracellularHydrolytic enzyme425, 427
  LysophospholipaseCell wall, surface, extracellularHydrolytic enzyme19, 23, 174, 355, 425, 427, 533
  Lysophospholipase-transacylaseExtracellularHydrolytic enzyme, putative virulence factor19, 217, 533, 534
 EsteraseExtracellularHydrolytic enzyme56, 419, 449, 551
 GlucoamylaseExtracellularHydrolytic enzyme82
 Hemolytic factorCell wall, extracellularHydrolytic enzyme317
 Acid phosphatasePeriplasmic, surfaceHydrolytic enzyme78, 105, 391, 547
 LipaseLIP1ExtracellularHydrolytic enzyme148
 HyaluronidaseExtracellularHydrolytic enzyme, virulence factor?499, 500
 Chondroitan sulfataseExtracellularHydrolytic enzyme, virulence factor?499, 500
 MetallopeptidaseCell wall, extracellular?Hydrolytic enzyme120, 121
 TrehalaseCell wall, extracellularHydrolytic enzyme362, 454